Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 2, 2007, Pages 492-500

  Dell'Aica, Isabella ^a   Niero, Raffaele ^b   Piazza, Francesco ^a,b   Cabrelle, Anna ^a,b   Sartor, Luigi ^a   Colalto, Cristiano ^a   Brunetta, Enrico ^a,b   Lorusso, Girieca ^c   Benelli, Roberto ^d   Albini, Adriana ^c   Calabrese, Fiorella ^a   Agostini, Carlo ^a,b   Garbisa, Spiridione ^a,e  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; GELATINASE B; HYPERFORIN; INTEGRIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MOTILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BICYCLO COMPOUNDS; CELL MOVEMENT; CHEMOTAXIS, LEUKOCYTE; CYCLOHEXYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; NEUTROPHILS; PHLOROGLUCINOL; PULMONARY FIBROSIS; TERPENES;

EID: 34247273630     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.116459     Document Type: Article

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