Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring

American Journal of Obstetrics and Gynecology

Volumn 196, Issue 5, 2007, Pages 477.e1-477.e7

  Choi, Gyu Yeon ^b   Tosh, Darran N ^b   Garg, Ambica ^b   Mansano, Roy ^b   Ross, Michael G ^a,b   Desai, Mina ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

fatty acid synthase; hepatic lobule; lipoprotein lipase; sterol regulatory element binding proteins (SREBP 1c); triglyceride

Indexed keywords

CHOLESTEROL; FATTY ACID SYNTHASE; LIPID; LIPOPROTEIN LIPASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; INTRAUTERINE GROWTH RETARDATION; LIPID ANALYSIS; LIPID LIVER LEVEL; LIPID METABOLISM; LIVER LEVEL; LIVER SIZE; LIVER STRUCTURE; LIVER WEIGHT; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGENY; RAT; SEX DIFFERENCE;

EID: 34247265995     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2007.02.024     Document Type: Article

References (37)

1. Vivian E.M. Type 2 diabetes in children and adolescents: the next epidemic?. Curr Med Res Opin 22 (2006) 297-306
2. Weiss R., and Caprio S. The metabolic consequences of childhood obesity. Best Pract Res Clin Endocrinol Metab 19 (2005) 405-419
3. Neuschwander-Tetri B.A. Fatty liver and the metabolic syndrome. Curr Opin Gastroenterol 23 (2007) 193-198
4. Targher G. Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens. Diabet Med 24 (2007) 1-6
5. Barker D.J., Hales C.N., Fall C.H., Osmond C., Phipps K., and Clark P.M. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36 (1993) 62-67
6. Gluckman P.D., and Hanson M.A. The developmental origins of the metabolic syndrome. Trends Endocrinol Metab 15 (2004) 183-187
7. Desai M., and Hales C.N. Role of fetal and infant growth in programming metabolism in later life. Biol Rev 72 (1997) 329-348
8. Roseboom T.J., van der Meulen J.H., Osmond C., Barker D.J., Ravelli A.C., and Bleker O.P. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 185 (2001) 93-98
9. Desai M., Crowther N., Ozanne S.E., Lucas A., and Hales C.N. Adult glucose and lipid metabolism may be programmed during fetal life. Biochem Soc Trans 23 (1995) 331-335
10. Lucas A., Baker B.A., Desai M., and Hales C.N. Nutrition in pregnant or lactating rats programs lipid metabolism in the offspring. Br J Nutr 76 (1996) 605-612
11. Desai M., Gayle D.A., Jooby B., and Ross M.G. Permanent reduction in heart and kidney organ growth in offspring of undernourished rat dams. Am J Obstet Gynecol 93 (2005) 1224-1232
12. Berney D.M., Desai M., Palmer D.J., et al. The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J Pathol 183 (1997) 109-115
13. Desai M., Crowther N.J., Lucas A., and Hales C.N. Organ-selective growth in the offspring of protein-restricted mothers. Br J Nutr 76 (1996) 591-603
14. Shimomura I., Bashmakov Y., Ikemoto S., Horton J.D., Brown M.S., and Goldstein J.L. Insulin selectively increases SREBP-k mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci 63 (1999) 13656-13661
15. Kim J.B., Sarraf P., Wright M., et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 101 (1998) 1-9
16. Evert M., Schneider-Stock R., and Dombrowski F. Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. Lab Investig 85 (2005) 99-108
17. Burns S.P., Desai M., Cohen R.D., et al. Gluconeogenesis, glucose handling and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 100 (1997) G1083-G1090
18. Inoue Y., Inoue J., Lambert G., Yim S.H., and Gonzalez F.J. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis. J Biol Chem 279 (2004) 44740-44748
19. Basso F., Freeman L., and Knapper C.L. Role of hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations. J Lipid Res 44 (2003) 296-302
20. Desai M., Gayle D.A., Jooby B., and Ross M.G. Programmed obesity in intrauterine growth restricted newborns: modulation by newborn nutrition. Am J Physiol Regul Integr Comp Physiol 288 (2005) R91-R96
21. Jungermann K. Functional heterogeneity of periportal and perivenous hepatocytes. Enzyme 35 (1986) 161-180
22. Guzman M., and Castro J. Zonation of fatty acid metabolism in rat liver. Biochem J 264 (1989) 107-113
23. Jungermann K. Dynamics of zonal hepatocyte heterogeneity: perinatal development and adaptive alterations during regeneration after partial hepatectomy, starvation and diabetes. Acta Histochem Suppl 32 (1986) 89-98
24. Katz N.R. Metabolic heterogeneity of hepatocytes across the liver acinus. J Nutr 122 (1992) 843-849
25. Desai M., Byrne C.D., Zhang J., Petry C.J., Lucas A., and Hales C.N. Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. Am J Physiol 272 (1997) G1083-G1090
26. Horton J.D., Shimomura I., Ikemoto S., Bashmakov Y., and Hammer R.E. Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem 278 (2003) 36652-36660
27. Yahagi N., Shimano H., Hasty A.H., et al. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice. J Biol Chem 277 (2002) 19353-19357
28. Camps L., Reina M., Llobera M., Bengtsson-Olivecrona G., Olivecrona T., and Vilaro S. Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution. J Lipid Res 32 (1991) 1877-1888
29. Peinado-Onsurbe J., Staels B., Deeb S., Ramirez I., Llobera M., and Auwerx J. Neonatal extinction of liver lipoprotein lipase expression. Biochim Biophys Acta 15 (1992) 281-286
30. Robinson D.S., and Seakins A. The development in the rat of fatty livers associated with reduced plasma-lipoprotein synthesis. Biochim Biophys Acta 30 (1962) 62 163-5
31. Fredrickson D.S., Levy R.I., and Lees R.S. Fat transport in lipoproteins: an integrated approach to mechanisms and disorders. N Engl J Med 276 (1967) 273-281
32. Shimomura I., Bashmakov Y., and Horton J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. Biol Chem 274 (1999) 30028-30032
33. Freedman D.S., Jacobsen S.J., Barboriak J.J., et al. Body fat distribution and male/female differences in lipids and lipoproteins. Circulation 81 (1990) 1498-1506
34. Regitz-Zagrosek V., Lehmkuhl E., and Weickert M.O. Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol 95 (2006) 136-147
35. Barker D.J.P., Martyn C.N., Osmond C., Hales C.N., and Fall C.H.D. Growth in utero and serum cholesterol concentrations in adult life. BMJ 307 (1993) 1524-1527
36. Roseboom T.J., van der Meulen J.H., Osmond C., Barker D.J., Ravelli A.C., and Bleker O.P. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 72 (2000) 1101-1106
37. Soto N., Bazaes R.A., Peña V., et al. insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab 88 (2003) 3645-3650