Exercise does not affect plasma concentrations of (R)- and (S)-carvedilol

Cardiovascular Drugs and Therapy

Volumn 16, Issue 2, 2002, Pages 133-140

  Stoschitzky, Kurt ^a   Koshucharova, Gergana ^a   Zweiker, Robert ^a   Lercher, Peter ^a   Maier, Robert ^a   Klein, Werner ^a   Zitta, Sabine ^a   Gruber, Leonhard ^b   Lamprecht, Günther ^b   Lindner, Wolfgang ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Beta blockers; Carvedilol; Exercise; Pharmacokinetics; Plasma concentrations

Indexed keywords

CARVEDILOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; EXERCISE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERTENSION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ANALYSIS OF VARIANCE; BLOOD; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION; STEREOISOMERISM;

ADMINISTRATION, ORAL; ADRENERGIC BETA-ANTAGONISTS; ADULT; ANALYSIS OF VARIANCE; CARBAZOLES; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; EXERCISE; HUMAN; HYPERTENSION; MALE; MIDDLE AGE; PROPANOLAMINES; STEREOISOMERISM; HUMANS; MIDDLE AGED;

EID: 0035997526     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015705516496     Document Type: Article

References (21)

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2. Adrenergic nerve stimulation induced release of propranolol from perfused hindlimb and spleen of the dog and associated changes in postjunctional response
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4. Depolarization-induced release of propranolol and atenolol from rat cortical synaptosomes
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6. Stereoselective uptake of atenolol into storage granules isolated from PC12 cells
7. Exercise-induced increments in plasma levels of propranolol and noradrenaline
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9. Unpredicted lack of effect of exercise on plasma concentrations of carvedilol
10. 1- and betal-adrenoceptors
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15. Assay and disposition of carvedilol enantiomers in humans and monkeys: Evidence of stereoselective presystemic metabolism
16. Measurement of carvedilol enantiomers in human plasma and urine using S-naproxen chloride for chiral derivatization
17. Stereoselective disposition of carvedilol is determined by CYP2D6
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19. Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities
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21. Carvedilol stereopharmacokinetics in rats: Affinities to blood constituents and tissues