Acetazolamide opens the muscular K(Ca)2+ channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis

Annals of Neurology

Volumn 48, Issue 3, 2000, Pages 304-312

  Tricarico, Domenico ^a   Barbieri, Mariagrazia ^a   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; CALCIUM CHANNEL; CALCIUM CHANNEL AFFECTING AGENT; SODIUM CHANNEL; THIAZIDE DIURETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE ANALYSIS; DEPOLARIZATION; DRUG EFFECT; HOMEOSTASIS; HYPOKALEMIA; INSULIN BLOOD LEVEL; MALE; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE STRENGTH; NONHUMAN; PERIODIC PARALYSIS; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

ACETAZOLAMIDE; ANIMALS; HOMEOSTASIS; HYPOKALEMIC PERIODIC PARALYSIS; MALE; MEMBRANE POTENTIALS; MUSCLES; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SARCOLEMMA;

EID: 0033843765     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200009)48:3<304::AID-ANA4>3.0.CO;2-A     Document Type: Article

References (29)

1. Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: A quantitative digital radiograph study
2. Acetazolamide in the treatment of acute mania
3. A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia
4. Episodic ataxia and channelopathies
5. Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2
6. Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation
7. Cydodextrins in acetazolamide eye drop formulations
8. Acetazolamide plus low-dose dexamethasone is better than acetazolamide alone to ameliorate symptoms of acute mountain sickness
9. Improvement of muscle strength in familial hypokalemic periodic paralyses with acetazolamide
10. The periodic paralyses and paramyotonia congenita
11. The familial periodic paralyses and nondystrophic myotonias
12. Molecular pathophysiology of voltage-gated ion channels
13. Ion-channel defects and aberrant excitability in myotonia and periodic paralysis
14. Voltage-gated ion channels and hereditary disease
15. + current
16. + channel of rat skeletal muscle is impaired in the hypokalemic state
17. Effects of potassium depletion and insulin on resting and stimulated skeletal rat muscle
18. + channels in patients with hypokalemic periodic paralysis
19. + depleted rat, an animal model of hypokalemic periodic paralysis
20. Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis
21. Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide
22. Inhibition and kinetic properties of membrane-bound carbonic anhydrases in rabbit skeletal muscles
23. Changes of the biophysical properties of calcium-activated potassium channels of rat skeletal muscle fibres during aging
24. Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle
25. + channel by insulin in rat skeletal muscle fibers
26. Insulin-induced hyperpolarization in mammalian skeletal muscle
27. Disturbances of potassium homeostasis in poisoning
28. Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres
29. 2+ channel expressed in Xenopus laevis oocyte