Characterization of HSP27 phosphorylation induced by microtubule interfering agents: Implication of p38 signalling pathway

Archives of Biochemistry and Biophysics

Volumn 461, Issue 1, 2007, Pages 123-129

  Casado, Pedro ^a   Zuazua Villar, Pedro ^a   Prado, Miguel A ^a   Valle, Eva del ^a   Iglesias, Juan Manuel ^a   Martínez Campa, Carlos ^a   Lazo, Pedro S ^a   Ramos, Sofía ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

2D PAGE; Breast cancer; HSP27; p38; Paclitaxel; Phosphorylation; Vincristine

Indexed keywords

HEAT SHOCK PROTEIN 27; SERINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; VINCRISTINE;

ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MICROTUBULE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE, TUMOR; HEAT-SHOCK PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICROTUBULES; NEOPLASM PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PHOSPHORYLATION; SERINE; TUBULIN MODULATORS; VINCRISTINE;

EID: 34247250215     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.01.027     Document Type: Article

References (19)

1. Jordan M.A., and Wilson L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer 4 (2004) 253-265
2. Wang T.H., Wang H.S., Ichijo H., Giannakakou P., Foster J.S., Fojo T., and Wimalasena J. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273 (1998) 4928-4936
3. Ruvolo P.P., Deng X., and May W.S. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia 15 (2001) 515-522
4. Garrido C., Ottavi P., Fromentin A., Hammann A., Arrigo A.P., Chauffert B., and Mehlen P. HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res. 57 (1997) 2661-2667
5. Bruey J.M., Paul C., Fromentin A., Hilpert S., Arrigo A.P., Solary E., and Garrido C. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene 19 (2000) 4855-4863
6. Charette S.J., Lavoie J.N., Lambert H., and Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell Biol. 20 (2000) 7602-7612
7. Garrido C., Gurbuxani S., Ravagnan L., and Kroemer G. Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem. Biophys. Res. Commun. 286 (2001) 433-442
8. Shin K.D., Lee M.Y., Shin D.S., Lee S., Son K.H., Koh S., Paik Y.K., Kwon B.M., and Han D.C. Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. J. Biol. Chem. 280 (2005) 41439-41448
9. Xu L., Chen S., and Bergan R.C. MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer. Oncogene (2006)
10. Stokoe D., Engel K., Campbell D.G., Cohen P., and Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 313 (1992) 307-313
11. Clifton A.D., Young P.R., and Cohen P. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett. 392 (1996) 209-214
12. New L., Jiang Y., Zhao M., Liu K., Zhu W., Flood L.J., Kato Y., Parry G.C., and Han J. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 17 (1998) 3372-3384
13. Casado P., Zuazua-Villar P., Valle E.D., Martinez-Campa C., Lazo P.S., and Ramos S. Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells. Cancer Lett. (2006)
14. M. Tuloup, C. Hernandez, I. Coro, C. Hoogland, P.-A. Binz, R.D. Appel, in Swiss Proteomics Society 2003 Congress: Understanding Biological Systems through Proteomics, 2003 pp. 174-176.
15. Huot J., Roy G., Lambert H., Chretien P., and Landry J. Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res. 51 (1991) 5245-5252
16. Martinez-Campa C., Casado P., Rodriguez R., Zuazua P., Garcia-Pedrero J.M., Lazo P.S., and Ramos S. Effect of Vinca alkaloids on ERalpha levels and Estradiol-induced responses in MCF-7 cells. Breast Cancer Res. Treat. 98 (2006) 81-89
17. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 (2000) 95-105
18. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., and Anderson D.W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 98 (2001) 13681-13686
19. Bacus S.S., Gudkov A.V., Lowe M., Lyass L., Yung Y., Komarov A.P., Keyomarsi K., Yarden Y., and Seger R. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 20 (2001) 147-155