-
1
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
Liu J, Farmer Jr. JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815 (1991)
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
Farmer Jr., J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
2
-
-
0025871394
-
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporine A
-
Flanagan MW, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporine A. Nature 352: 803-806 (1991)
-
(1991)
Nature
, vol.352
, pp. 803-806
-
-
Flanagan, M.W.1
Corthesy, B.2
Bram, R.J.3
Crabtree, G.R.4
-
3
-
-
0026632557
-
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
-
O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-694 (1992)
-
(1992)
Nature
, vol.357
, pp. 692-694
-
-
O'Keefe, S.J.1
Tamura, J.2
Kincaid, R.L.3
Tocci, M.J.4
O'Neill, E.A.5
-
4
-
-
0026643141
-
Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation
-
Clipstone NA, Crabtree GR. Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation. Nature 357: 695-697 (1992)
-
(1992)
Nature
, vol.357
, pp. 695-697
-
-
Clipstone, N.A.1
Crabtree, G.R.2
-
5
-
-
0033525748
-
2+, calcineurin, and NF-AT
-
2+, calcineurin, and NF-AT. Cell 96: 611-614 (1999)
-
(1999)
Cell
, vol.96
, pp. 611-614
-
-
Crabtree, G.R.1
-
6
-
-
0036094174
-
Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs
-
Strauss G, Osen W, Debatin KM. Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs. Clin Exp Immunol 128: 255-266 (2002)
-
(2002)
Clin Exp Immunol
, vol.128
, pp. 255-266
-
-
Strauss, G.1
Osen, W.2
Debatin, K.M.3
-
7
-
-
57849099861
-
The George Hitchings and Gertrude Elion Lecture: The pharmacology of azathioprine
-
Elion GB. The George Hitchings and Gertrude Elion Lecture: the pharmacology of azathioprine. Ann NY Acad Sci 685: 1239-1256 (1990)
-
(1990)
Ann NY Acad Sci
, vol.685
, pp. 1239-1256
-
-
Elion, G.B.1
-
8
-
-
0034045586
-
Mycophenolate mofetil and its mechanism of action
-
Allison AC, Eugui EM. Mycophenolate mofetil and its mechanism of action. Immunopharmacology 47: 85-118 (2000)
-
(2000)
Immunopharmacology
, vol.47
, pp. 85-118
-
-
Allison, A.C.1
Eugui, E.M.2
-
9
-
-
0021275785
-
Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis
-
Morris PG, Hargreave AD, Duvall E, Wylie AH. Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis. Am J Pathol 115: 426-436 (1984)
-
(1984)
Am J Pathol
, vol.115
, pp. 426-436
-
-
Morris, P.G.1
Hargreave, A.D.2
Duvall, E.3
Wylie, A.H.4
-
10
-
-
0029857032
-
A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
-
Suzuki S, Li XK, Enosawa S, Shinomiya T. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 89: 518-523 (1996)
-
(1996)
Immunology
, vol.89
, pp. 518-523
-
-
Suzuki, S.1
Li, X.K.2
Enosawa, S.3
Shinomiya, T.4
-
11
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 124: 471-484 (2006)
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
12
-
-
0014325205
-
-
Tamura G, Suzuki S, Takatsuki A, Ando K, Arima K. Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I) J Antibiot 21: 539-544 (1968)
-
Tamura G, Suzuki S, Takatsuki A, Ando K, Arima K. Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I) J Antibiot 21: 539-544 (1968)
-
-
-
-
13
-
-
0014580356
-
The molecular structure of ascochlorin
-
Nawata Y, Ando K, Tamura G, Arima K, Iitake Y The molecular structure of ascochlorin. J Antibiot 22: 511-512 (1969)
-
(1969)
J Antibiot
, vol.22
, pp. 511-512
-
-
Nawata, Y.1
Ando, K.2
Tamura, G.3
Arima, K.4
Iitake, Y.5
-
14
-
-
0034687190
-
Total synthesis of (-)-ascochlorin via a cyclobutanone-based benzannulation strategy
-
Dudley GB, Takaki KS, Cha DD, Danheiser RL. Total synthesis of (-)-ascochlorin via a cyclobutanone-based benzannulation strategy. Org Lett 2: 3407-3410 (2000)
-
(2000)
Org Lett
, vol.2
, pp. 3407-3410
-
-
Dudley, G.B.1
Takaki, K.S.2
Cha, D.D.3
Danheiser, R.L.4
-
15
-
-
0009002739
-
Enhanced excretion of fecal neutral sterols and the hypercholesterolemic properties of 4 -O-methylascochlorin
-
Hosokawa T, Sawada M, Ando K, Tamura G. Enhanced excretion of fecal neutral sterols and the hypercholesterolemic properties of 4 -O-methylascochlorin. Agric Biol Chem 44: 2461-2468 (1980)
-
(1980)
Agric Biol Chem
, vol.44
, pp. 2461-2468
-
-
Hosokawa, T.1
Sawada, M.2
Ando, K.3
Tamura, G.4
-
16
-
-
0019870910
-
Alteration of cholesterol metabolism by 4-O-methylascochlorin in rats
-
Hosokawa T, Sawada M, Ando K, Tamura G. Alteration of cholesterol metabolism by 4-O-methylascochlorin in rats. Lipids 16: 433-438 (1981)
-
(1981)
Lipids
, vol.16
, pp. 433-438
-
-
Hosokawa, T.1
Sawada, M.2
Ando, K.3
Tamura, G.4
-
17
-
-
0019491674
-
Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats
-
Hosokawa T, Okutomi T, Sawada M, Ando K, Tamura G. Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats. Eur J Pharmacol 69: 429-438 (1981)
-
(1981)
Eur J Pharmacol
, vol.69
, pp. 429-438
-
-
Hosokawa, T.1
Okutomi, T.2
Sawada, M.3
Ando, K.4
Tamura, G.5
-
18
-
-
0020445601
-
An ascochlorin derivative, AS-6 potentiates insulin action in streptozotocin diabetic mice and rats
-
Hosokawa T, Ando K, Tamura G. An ascochlorin derivative, AS-6 potentiates insulin action in streptozotocin diabetic mice and rats. Agric Biol Chem 46: 775-781 (1982)
-
(1982)
Agric Biol Chem
, vol.46
, pp. 775-781
-
-
Hosokawa, T.1
Ando, K.2
Tamura, G.3
-
19
-
-
0021989797
-
An ascochlorin derivative, AS-6, reduces insulin resistance in the genetically obese diabetic mice
-
Hosokawa T, Ando K, Tamura G. An ascochlorin derivative, AS-6, reduces insulin resistance in the genetically obese diabetic mice. Diabetes 34: 267-274 (1982)
-
(1982)
Diabetes
, vol.34
, pp. 267-274
-
-
Hosokawa, T.1
Ando, K.2
Tamura, G.3
-
20
-
-
0022551543
-
In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system
-
Magae J, Suzuki S, Nagai K, Yamasaki M, Ando K, Tamura G. In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system. Cancer Res 46: 1073-1078 (1986)
-
(1986)
Cancer Res
, vol.46
, pp. 1073-1078
-
-
Magae, J.1
Suzuki, S.2
Nagai, K.3
Yamasaki, M.4
Ando, K.5
Tamura, G.6
-
21
-
-
0023778365
-
Antitumor and antimetastatic activity of an antibiotic, ascofuranone and activation of phagocytes
-
Magae J, Hayasaki J, Matsuda Y, Hotta M, Hosokawa T, Suzuki S, Nagai K, Ando K, Tamura G. Antitumor and antimetastatic activity of an antibiotic, ascofuranone and activation of phagocytes. J Antibiot 40: 959-965 (1988)
-
(1988)
J Antibiot
, vol.40
, pp. 959-965
-
-
Magae, J.1
Hayasaki, J.2
Matsuda, Y.3
Hotta, M.4
Hosokawa, T.5
Suzuki, S.6
Nagai, K.7
Ando, K.8
Tamura, G.9
-
22
-
-
0020380282
-
Antitumor protective property of an isoprenoid antibiotic, ascofuranone
-
Magae J, Hosokawa T, Ando K, Nagai K, Tamura G. Antitumor protective property of an isoprenoid antibiotic, ascofuranone. J Antibiot 35: 1547-1552 (1982)
-
(1982)
J Antibiot
, vol.35
, pp. 1547-1552
-
-
Magae, J.1
Hosokawa, T.2
Ando, K.3
Nagai, K.4
Tamura, G.5
-
23
-
-
0014527592
-
Antiviral and antitumor antibiotics. XIV Effects of ascochlorin and other respiration inhibitors on multiplication of Newcastle disease virus in cultured cells
-
Takatsuki A, Tamura G, Arima K. Antiviral and antitumor antibiotics. XIV Effects of ascochlorin and other respiration inhibitors on multiplication of Newcastle disease virus in cultured cells. Appl Microbiol 17: 825-829 (1969)
-
(1969)
Appl Microbiol
, vol.17
, pp. 825-829
-
-
Takatsuki, A.1
Tamura, G.2
Arima, K.3
-
24
-
-
85004573888
-
Effects of microbial products on glucose consumption and morphology of macrophages
-
Magae J, Munemura K, Ichikawa C, Osada K, Hanada T, Tsuji RF, Yamashita M, Hino A, Horiuchi T, Uramoto M, Yamasaki, Endo T, Nagai K. Effects of microbial products on glucose consumption and morphology of macrophages. Biosci Biotechnol Biosci 57: 1628-1631 (1993)
-
(1993)
Biosci Biotechnol Biosci
, vol.57
, pp. 1628-1631
-
-
Magae, J.1
Munemura, K.2
Ichikawa, C.3
Osada, K.4
Hanada, T.5
Tsuji, R.F.6
Yamashita, M.7
Hino, A.8
Horiuchi, T.9
Uramoto, M.10
Yamasaki11
Endo, T.12
Nagai, K.13
-
26
-
-
0032084824
-
Selective induction of interleukin-1 production and tumor killing activity of macrophages through apoptosis by the inhibition of oxidative respiration
-
Ashikaga T, Honma M, Munemura K, Kataoka T, Endo T, Yamasaki M, Magae J, Nagai K. Selective induction of interleukin-1 production and tumor killing activity of macrophages through apoptosis by the inhibition of oxidative respiration. Biosci Biotchnol Biochem 62: 1115-1121 (1998)
-
(1998)
Biosci Biotchnol Biochem
, vol.62
, pp. 1115-1121
-
-
Ashikaga, T.1
Honma, M.2
Munemura, K.3
Kataoka, T.4
Endo, T.5
Yamasaki, M.6
Magae, J.7
Nagai, K.8
-
27
-
-
0036256532
-
PPARγ activation and adipocyte differentiation induced by AS-6, a prenyl-phenol antidiabetic antibiotic
-
Togashi M, Masuda H, Kawada T, Tanaka M, Saida K, Ando K, Tamura G, Magae J. PPARγ activation and adipocyte differentiation induced by AS-6, a prenyl-phenol antidiabetic antibiotic. J Antibiot 55: 417-122 (2002)
-
(2002)
J Antibiot
, vol.55
, pp. 417-122
-
-
Togashi, M.1
Masuda, H.2
Kawada, T.3
Tanaka, M.4
Saida, K.5
Ando, K.6
Tamura, G.7
Magae, J.8
-
28
-
-
0141567443
-
Ascochlorin derivatives as ligands for nuclear hormone receptors
-
Togashi M, Ozawa S, Abe S, Nishimura T, Tsuruga M, Ando K, Tamura G, Kuwahara S, Ubukata M, Magae J. Ascochlorin derivatives as ligands for nuclear hormone receptors. J Med Chem 46: 4113-4123 (2003)
-
(2003)
J Med Chem
, vol.46
, pp. 4113-4123
-
-
Togashi, M.1
Ozawa, S.2
Abe, S.3
Nishimura, T.4
Tsuruga, M.5
Ando, K.6
Tamura, G.7
Kuwahara, S.8
Ubukata, M.9
Magae, J.10
-
29
-
-
21644444034
-
Ascochlorin inhibits matrixmetalloproteinase-9 expression by suppressing AP-1 mediated-gene expression through the ERK1/2 signaling pathway: Inhibitory effects of ascochlorin on the invasion of renal carcinoma cells
-
Hong SH, Park KK, Magae J, Ando K, Lee TS, Kwon TK, Kwak JY, Kim CH, Chang YC. Ascochlorin inhibits matrixmetalloproteinase-9 expression by suppressing AP-1 mediated-gene expression through the ERK1/2 signaling pathway: Inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J Biol Chem 280: 25202-25209 (2005)
-
(2005)
J Biol Chem
, vol.280
, pp. 25202-25209
-
-
Hong, S.H.1
Park, K.K.2
Magae, J.3
Ando, K.4
Lee, T.S.5
Kwon, T.K.6
Kwak, J.Y.7
Kim, C.H.8
Chang, Y.C.9
-
30
-
-
3342909628
-
Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines
-
Tsuruga M, Nakajima H, Ozawa S, Togashi M, Chang YC, Ando K, Magae J. Characterization of 4-O-methyl-ascochlorin-induced apoptosis in comparison with typical apoptotic inducers in human leukemia cell lines. Apoptosis 9: 429-435 (2004)
-
(2004)
Apoptosis
, vol.9
, pp. 429-435
-
-
Tsuruga, M.1
Nakajima, H.2
Ozawa, S.3
Togashi, M.4
Chang, Y.C.5
Ando, K.6
Magae, J.7
-
31
-
-
0026458225
-
Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T cells
-
Tsuji RF, Magae J, Yamashita M, Nagai K, Yamasaki M. Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T cells. J Antibiot 45: 1295-1302 (1992)
-
(1992)
J Antibiot
, vol.45
, pp. 1295-1302
-
-
Tsuji, R.F.1
Magae, J.2
Yamashita, M.3
Nagai, K.4
Yamasaki, M.5
-
32
-
-
0025165636
-
Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune system
-
Tsuji RF, Yamamoto M, Nakamura A, Kataoka T, Magae J, Nagai K, Yamasaki M. Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune system. J Antibiot 43: 1293-1301 (1990)
-
(1990)
J Antibiot
, vol.43
, pp. 1293-1301
-
-
Tsuji, R.F.1
Yamamoto, M.2
Nakamura, A.3
Kataoka, T.4
Magae, J.5
Nagai, K.6
Yamasaki, M.7
-
33
-
-
0027942110
-
Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity
-
Kataoka T, Takaku K, Magae J, Shinohara N, Takayama H, Kondo S, Nagai K. Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar type H(+)-ATPase, on CTL-mediated cytotoxicity. J Immunol 153: 3938-3947 (1994)
-
(1994)
J Immunol
, vol.153
, pp. 3938-3947
-
-
Kataoka, T.1
Takaku, K.2
Magae, J.3
Shinohara, N.4
Takayama, H.5
Kondo, S.6
Nagai, K.7
-
34
-
-
0033974672
-
+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B
-
+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B. Immunology 99: 243-248 (2000)
-
(2000)
Immunology
, vol.99
, pp. 243-248
-
-
Lee, M.H.1
Kataoka, T.2
Honjo, N.3
Magae, J.4
Nagai, K.5
-
35
-
-
0026717868
-
A fail-safe mechanism for maintaining self-tolerance
-
Guexder S, Matzinger P. A fail-safe mechanism for maintaining self-tolerance. J Exp Med 176: 553-564 (1992)
-
(1992)
J Exp Med
, vol.176
, pp. 553-564
-
-
Guexder, S.1
Matzinger, P.2
-
37
-
-
0032482356
-
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
-
Bennett SR, Carbone FR, Karamalis F, Flavell RA, Miller JFAP, Heath WR. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393: 478-480 (1998)
-
(1998)
Nature
, vol.393
, pp. 478-480
-
-
Bennett, S.R.1
Carbone, F.R.2
Karamalis, F.3
Flavell, R.A.4
Miller, J.F.A.P.5
Heath, W.R.6
-
38
-
-
0032482474
-
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
-
Schoenberger SP, Toes REM, van der Voor EIH, Offringa R, Melief CJM. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393: 480-483 (1998)
-
(1998)
Nature
, vol.393
, pp. 480-483
-
-
Schoenberger, S.P.1
Toes, R.E.M.2
van der Voor, E.I.H.3
Offringa, R.4
Melief, C.J.M.5
-
39
-
-
0032482274
-
Immunology: Licence to kill
-
Lanzavecchia A. Immunology: licence to kill. Nature 393: 413-414 (1998)
-
(1998)
Nature
, vol.393
, pp. 413-414
-
-
Lanzavecchia, A.1
-
40
-
-
0034292414
-
CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation
-
Zhan Y, Corbett AJ, Brady JL, Sutherland RM, Lew AM. CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation. J Immunol 165: 3612-3619 (2000)
-
(2000)
J Immunol
, vol.165
, pp. 3612-3619
-
-
Zhan, Y.1
Corbett, A.J.2
Brady, J.L.3
Sutherland, R.M.4
Lew, A.M.5
-
41
-
-
0035804263
-
It takes more than two to tango
-
Schwartz RH. It takes more than two to tango. Nature 409: 31-32 (2001)
-
(2001)
Nature
, vol.409
, pp. 31-32
-
-
Schwartz, R.H.1
|