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Ding M, Cui S, Li C, et al. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med 2006; 12:1081-1087. Elegant demonstration of the ability of podocytes to become potent inflammatory mediators of proliferative injury within the glomerulus. This study significantly extends the realm and definition of the podocytopathies.
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Sagrinati C, Netti GS, Mazzinghi B, et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol 2006; 17:2443-2456. The first demonstration that a stem cell niche appears to be present within the glomerulus along the urinary pole of Bowman's capsule.
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