Anaphylaxis during anaesthesia: Diagnostic approach

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 5, 2007, Pages 471-487

  Ebo, D G ^a   Fisher, M M ^b   Hagendorens, M M ^a   Bridts, C H ^a   Stevens, W J ^a,c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Campus Drie Eiken ^*  (Belgium)

Author keywords

Anaesthesia; Anaphylaxis; Antiseptics; Diagnosis; Hypnotics; Latex; Neuromuscular blocking agent; Opioids; Tryptase

Indexed keywords

ACETYLSALICYLIC ACID; BACITRACIN; BETA LACTAM ANTIBIOTIC; CEPHALOSPORIN; CHLORHEXIDINE; CODEINE; ETOMIDATE; FENTANYL; HYPNOTIC AGENT; KETAMINE; METHOHEXITAL; MIDAZOLAM; MORPHINE; NEUROMUSCULAR BLOCKING AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PANCURONIUM; PARACETAMOL; PENICILLIN DERIVATIVE; PETHIDINE; PHOLCODINE; PROPOFOL; QUINOLONE DERIVATIVE; RIFAMYCIN; ROCURONIUM; RUBBER; TEICOPLANIN; THIOPENTAL; UNINDEXED DRUG; VECURONIUM;

ANAMNESIS; ANAPHYLAXIS; ANESTHESIA; CELL ACTIVATION; CROSS REACTION; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; FOOD ALLERGY; HUMAN; PERIOPERATIVE PERIOD; PRICK TEST; PRIORITY JOURNAL; RED MAN SYNDROME; REVIEW; SENSITIVITY AND SPECIFICITY; SKIN TEST;

ANAPHYLAXIS; ANESTHESIA; ANIMALS; HUMANS;

EID: 34247210651     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01347.x     Document Type: Review

References (227)

1. Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832-836.
2. Murat I. Anaphylactic reactions during paediatric anaesthesia; results of the survey of the French Society of Paediatric Anaesthetists (ADARPEF). Paediatr Anaesth 1993;3:339-343.
3. Laxenaire MC. [Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994 - December 1996)]. Ann Fr Anesth Reanim 1999;18:796-809.
4. Fisher MM, Baldo BA. The incidence and clinical features of anaphylactic reactions during anesthesia in Australia. Ann Fr Anesth Reanim 1993;12:97-104.
5. Lieberman P. Anaphylactic reactions during surgical and medical procedures. J Allergy Clin Immunol 2002;110(2 Suppl.):S64-S69.
6. Fisher MM. Intradermal testing after anaphylactoid reaction to anaesthetic drugs: practical aspects of performance and interpretation. Anaesth Intensive Care 1984;12:115-120.
7. Laurent J. Commission tripartite de consensus en allergologie. Rev Fr Allergol 1997;37:776-777.
8. Brockow K, Romano A, Blanca M, Ring J, Pichler W, Demoly P. General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 2002;57:45-51.
9. Mertes PM, Laxenaire MC, Lienhart A, Aberer W, Ring J, Pichler WJ et al. Reducing the risk of anaphylaxis during anaesthesia: guidelines for clinical practice. J Investig Allergol Clin Immunol 2005;15:91-101.
10. Patriarca G, Schiavino D, Nucera E, Milani A. Positive allergological tests may turn negative with no further exposure to the specific allergen: a long-term, prospective, follow-up study in patients allergic to4 penicillin. J Investig Allergol Clin Immunol 1996;6:162-165.
11. Blanca M, Torres MJ, Garcia JJ, Romano A, Mayorga C, de Ramon E et al. Natural evolution of skin test sensitivity in patients allergic to betalactam antibiotics. J Allergy Clin Immunol 1999;103(5 Pt 1):918-924.
12. Fisher MM, Baldo BA. Persistence of allergy to anaesthetic drugs. Anaesth Intensive Care 1992;20:143-146.
13. Demoly P, Kropf R, Bircher A, Pichler WJ. Drug hypersensitivity: questionnaire. EAACI interest group on drug hypersensitivity. Allergy 1999;54:999-1003.
14. Mertes PM, Laxenaire MC, Alla F. Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000. Anesthesiology 2003;99:536-545.
15. Harboe T, Guttormsen AB, Irgens A, Dybendal T, Florvaag E. Anaphylaxis during anesthesia in Norway: a 6-year single-center follow-up study. Anesthesiology 2005;102:897-903.
16. Karila C, Brunet-Langot D, Labbez F, Jacqmarcq O, Ponvert C, Paupe J et al. Anaphylaxis during anesthesia: results of a 12-year survey at a French pediatric center. Allergy 2005;60:828-834.
17. Garvey LH, Roed-Petersen J, Husum B. Anaphylactic reactions in anaesthetised patients - four cases of chlorhexidine allergy. Acta Anaesthesiol Scand 2001;45:1290-1294.
18. Garvey LH, Roed-Petersen J, Menne T, Husum B. Danish Anaesthesia Allergy Centre - preliminary results. Acta Anaesthesiol Scand 2001;45:1204-1209.
19. Mertes PM, Laxenaire MC. Allergic reactions occurring during anaesthesia. Eur J Anaesthesiol 2002;19:240-262.
20. Fisher MM, Doig GS. Prevention of anaphylactic reactions to anaesthetic drugs. Drug Saf 2004;27:393-410.
21. Caughey GH. Tryptase genetics and anaphylaxis. J Allergy Clin Immunol 2006;117:1411-1414.
22. Laroche D, Vergnaud MC, Sillard B, Soufarapis H, Bricard H. Biochemical markers of anaphylactoid reactions to drugs. Comparison of plasma histamine and tryptase. Anesthesiology 1991;75:945-949.
23. Schwartz LB, Irani AM, Roller K, Castells MC, Schechter NM. Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J Immunol 1987;138:2611-2615.
24. Vinuya RZ, Simon MR, Schwartz LB. Elevated serum tryptase levels in a patient with protracted anaphylaxis. Ann Allergy 1994;73:232-234.
25. Schwartz LB, Sakai K, Bradford TR, Ren S, Zweiman B, Worobec AS et al. The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis. J Clin Invest 1995;96:2702-2710.
26. Florian S, Krauth MT, Simonitsch-Klupp I, Sperr WR, Fritsche-Polanz R, Sonneck K et al. Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. Int Arch Allergy Immunol 2005;136:273-280.
27. Randall B, Butts J, Halsey JF. Elevated postmortem tryptase in the absence of anaphylaxis. J Forensic Sci 1995;40:208-211.
28. Edston E, Hage-Hamsten M. beta-Tryptase measurements post-mortem in anaphylactic deaths and in controls. Forensic Sci Int 1998;93:135-142.
29. Fisher MM, Baldo BA. Mast cell tryptase in anaesthetic anaphylactoid reactions. Br J Anaesth 1998;80:26-29.
30. Mertes PM, Laxenaire MC. [Anaphylactic and anaphylactoid reactions occurring during anaesthesia in France. Seventh epidemiologic survey (January 2001-December 2002)]. Ann Fr Anesth Reanim 2004;23:1133-1143.
31. Laxenaire MC. Drugs and other agents involved in anaphylactic shock occurring during anaesthesia. A French multicenter epidemiological inquiry. Ann Fr Anesth Reanim 1993;12:91-96.
32. Naguib M, Magboul MM. Adverse effects of neuromuscular blockers and their antagonists. Drug Saf 1998;18:99-116.
33. Baldo BA, Fisher MM. Substituted ammonium ions as allergenic determinants in drug allergy. Nature 1983;306:262-264.
34. Didier A, Cador D, Bongrand P, Furstoss R, Fourneron P, Senft M et al. Role of the quaternary ammonium ion determinants in allergy to muscle relaxants. J Allergy Clin Immunol 1987;79:578-584.
35. Marone G, Stellato C. Activation of human mast cells and basophils by general anaesthetic drugs. Monogr Allergy 1992;30:54-73.
36. Naguib M, Samarkandi AH, Bakhamees HS, Magboul MA, el Bakry AK. Histamine-release haemodynamic changes produced by rocuronium, vecuronium, mivacurium, atracurium and tubocurarine. Br J Anaesth 1995;75:588-592.
37. Koppert W, Blunk JA, Petersen LJ, Skov P, Rentsch K, Schmelz M. Different patterns of mast cell activation by muscle relaxants in human skin. Anesthesiology 2001;95:659-667.
38. Doenicke A, Soukup J, Hoernecke R, Moss J. The lack of histamine release with cisatracurium: a double-blind comparison with vecuronium. Anesth Analg 1997;84:623-628.
39. Doenicke AW, Czeslick E, Moss J, Hoernecke R. Onset time, endotracheal intubating conditions, and plasma histamine after cisatracurium and vecuronium administration. Anesth Analg 1998;87:434-438.
40. Hepner DL, Castells MC. Anaphylaxis during the perioperative period. Anesth Analg 2003;97:1381-1395.
41. Fisher MM. Anaphylaxis to muscle relaxants: cross sensitivity between relaxants. Anaesth Intensive Care 1980;8:211-213.
42. Baldo BA, Fisher MM. Anaphylaxis to muscle relaxant drugs: cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay. Mol Immunol 1983;20:1393-1400.
43. Harle DG, Baldo BA, Fisher MM. Cross-reactivity of metocurine, atracurium, vecuronium and fazadinium with IgE antibodies from patients unexposed to these drugs but allergic to other myoneural blocking drugs. Br J Anaesth 1985;57:1073-1076.
44. Moneret-Vautrin DA, Gueant JL, Kamel L, Laxenaire MC, el Kholty S, Nicolas JP. Anaphylaxis to muscle relaxants: cross-sensitivity studied by radioimmunoassays compared to intradermal tests in 34 cases. J Allergy Clin Immunol 1988;82(5 Pt 1):745-752.
45. Laxenaire MC, Gastin I, Moneret-Vautrin DA, Widmer S, Gueant JL. Cross-reactivity of rocuronium with other neuromuscular blocking agents. Eur J Anaesthesiol Suppl 1995;11: 55-64.
46. Romano A, Gueant-Rodriguez RM, Viola M, Gaeta F, Caruso C, Gueant JL. Cross-reactivity among drugs: clinical problems. Toxicology 2005;209:169- 179.
47. Thacker MA, Davis FM. Subsequent general anaesthesia in patients with a history of previous anaphylactoid/ anaphylactic reaction to muscle relaxant. Anaesth Intensive Care 1999;27:190-193.
48. Fisher MM, Bowey CJ. Intradermal compared with prick testing in the diagnosis of anaesthetic allergy. Br J Anaesth 1997;79:59-63.
49. Thong BY, Yeow C. Anaphylaxis during surgical and interventional procedures. Ann Allergy Asthma Immunol 2004;92:619-628.
50. Fisher MM, Merefield D, Baldo B. Failure to prevent an anaphylactic reaction to a second neuromuscular blocking drug during anaesthesia. Br J Anaesth 1999;82:770-773.
51. Levy JH, Gottge M, Szlam F, Zaffer R, McCall C. Weal and flare responses to intradermal rocuronium and cisatracurium in humans. Br J Anaesth 2000;85:844-849.
52. Berg CM, Heier T, Wilhelmsen V, Florvaag E. Rocuronium and cisatracurium-positive skin tests in nonallergic volunteers: determination of drug concentration thresholds using a dilution titration technique. Acta Anaesthesiol Scand 2003;47:576-582.
53. Dhonneur G, Combes X, Chassard D, Merle JC. Skin sensitivity to rocuronium and vecuronium: a randomized controlled prick-testing study in healthy volunteers. Anesth Analg 2004; 98:986-989.
54. Fisher M. Prick testing for neuromuscular blocking drugs. Anesth Analg 2004;99:1880-1881.
55. Tamayo E, Rodriguez-Ceron G, Gomez-Herreras JI, Fernandez A, Castrodeza J, Alvarez FJ. Prick-test evaluation to anaesthetics in patients attending a general allergy clinic. Eur J Anaesthesiol 2006;23:1-6.
56. Fisher MM, Baldo BA. Immunoassays in the diagnosis of anaphylaxis to neuromuscular blocking drugs: the value of morphine for the detection of IgE antibodies in allergic subjects. Anaesth Intensive Care 2000;28:167-170.
57. Florvaag E, Johansson SG, Oman H, Venemalm L, Degerbeck F, Dybendal T et al. Prevalence of IgE antibodies to morphine. Relation to the high and low incidences of NMBA anaphylaxis in Norway and Sweden, respectively. Acta Anaesthesiol Scand 2005;49:437-444.
58. Gueant JL, Mata E, Monin B, Moneret-Vautrin DA, Kamel L, Nicolas JP et al. Evaluation of a new reactive solid phase for radioimmunoassay of serum specific IgE against muscle relaxant drugs. Allergy 1991;46:452-458.
59. Laxenaire MC, Mertes PM. Anaphylaxis during anaesthesia. Results of a two-year survey in France. Br J Anaesth 2001;87:549-558.
60. Mertes PM, Laxenaire MC. Adverse reactions to neuromuscular blocking agents. Curr Allergy Asthma Rep 2004;4:7-16.
61. Guilloux L, Ricard-Blum S, Ville G, Motin J. A new radioimmunoassay using a commercially available solid support for the detection of IgE antibodies against muscle relaxants. J Allergy Clin Immunol 1992;90:153-159.
62. Harle DG, Baldo BA, Fisher MM. The molecular basis of IgE antibody binding to thiopentone. Binding of IgE from thiopentone-allergic and nonallergic subjects. Mol Immunol 1990;27:853-858.
63. Ebo DG, Bridts CH, Hagendorens MM, Mertens CH, De Clerck LS, Stevens WJ. Flow-assisted diagnostic management of anaphylaxis from rocuronium bromide. Allergy 2006;61:935-939.
64. Abuaf N, Rajoely B, Ghazouani E, Levy DA, Pecquet C, Chabane H et al. Validation of a flow cytometric assay detecting in vitro basophil activation for the diagnosis of muscle relaxant allergy. J Allergy Clin Immunol 1999;104(2 Pt 1):411-418.
65. Monneret G, Benoit Y, Debard AL, Gutowski MC, Topenot I, Bienvenu J. Monitoring of basophil activation using CD63 and CCR3 in allergy to muscle relaxant drugs. Clin Immunol 2002;102:192-199.
66. Sudheer PS, Hall JE, Read GF, Rowbottom AW, Williams PE. Flow cytometric investigation of peri-anaesthetic anaphylaxis using CD63 and CD203c. Anaesthesia 2005;60:251-256.
67. Kvedariene V, Kamey S, Ryckwaert Y, Rongier M, Bousquet J, Demoly P et al. Diagnosis of neuromuscular blocking agent hypersensitivity reactions using cytofluorimetric analysis of basophils. Allergy 2006;61:311-315.
68. Porri F, Lemiere C, Birnbaum J, Guilloux L, Lanteaume A, Didelot R et al. Prevalence of latex sensitization in subjects attending health screening: implications for a perioperative screening. Clin Exp Allergy 1997;27:413-417.
69. Ebo DG, Stevens WJ. IGE-mediated natural rubber latex allergy: an update. Acta Clin Belg 2002;57:58-70.
70. Hepner DL, Castells MC. Latex allergy: an update. Anesth Analg 2003;96:1219-1229.
71. Turjanmaa K, Reunala T, Tuimala R, Karkkainen T. Severe IgE-mediated allergy to surgical gloves. Allergy 1984;2:S35.
72. Mertes PM, Mouton C, Fremont S, Brugerolle B, Moneret-Vautrin DA, Lavaud F et al. Latex hypersensitivity in spinal cord injured adult patients. Anaesth Intensive Care 2001;29:393-399.
73. Blanco C, Carrillo T, Castillo R, Quiralte J, Cuevas M. Latex allergy: clinical features and cross-reactivity with fruits. Ann Allergy 1994;73:309-314.
74. Garcia Ortiz JC, Moyano JC, Alvarez M, Bellido J. Latex allergy in fruitallergic patients. Allergy 1998;53:532-536.
75. Hamilton RG, Adkinson NF Jr. Diagnosis of natural rubber latex allergy: multicenter latex skin testing efficacy study. Multicenter Latex Skin Testing Study Task Force. J Allergy Clin Immunol 1998;102:482-490.
76. Katelaris CH, Widmer RP, Lazarus RM, Baldo B. Screening for latex allergy with a questionnaire: comparison with latex skin testing in a group of dental professionals. Aust Dent J 2002;47:152-155.
77. Ebo DG, Stevens WJ, Bridts CH, De Clerck LS. Latex-specific IgE, skin testing, and lymphocyte transformation to latex in latex allergy. J Allergy Clin Immunol 1997;100:618-623.
78. Hamilton RG, Peterson EL, Ownby DR. Clinical and laboratory-based methods in the diagnosis of natural rubber latex allergy. J Allergy Clin Immunol 2002;110(2 Suppl.):S47-S56.
79. Suli C, Lorini M, Mistrello G, Tedeschi A. Diagnosis of latex hypersensitivity: comparison of different methods. Allerg Immunol (Paris) 2006;38:24-30.
80. Ebo DG, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy. Clin Exp Allergy 2004;34:137-144.
81. Ebo DG, Lechkar B, Schuerwegh AJ, Bridts CH, De Clerck LS, Stevens WJ. Validation of a two-color flow cytometric assay detecting in vitro basophil activation for the diagnosis of IgEmediated natural rubber latex allergy. Allergy 2002;57:706-712.
82. Hemery ML, Arnoux B, Dhivert-Donnadieu H, Rongier M, Barbotte E, Verdier R et al. Confirmation of the diagnosis of natural rubber latex allergy by the Basotest method. Int Arch Allergy Immunol 2005;136:53-57.
83. Sanz ML, Gamboa PM, Garcia-Aviles C, Vila L, Dieguez I, Antepara I et al. Flow-cytometric cellular allergen stimulation test in latex allergy. Int Arch Allergy Immunol 2003;130:33-39.
84. Quirce S, Swanson MC, Fernandez-Nieto M, de las HM, Cuesta J, Sastre J. Quantified environmental challenge with absorbable dusting powder aerosol from natural rubber latex gloves. J Allergy Clin Immunol 2003;111:788-794.
85. Acero S, Alvarez MJ, Garcia BE, Echechipia S, Olaguibel JM, Tabar AI. Occupational asthma from natural rubber latex. Specific inhalation challenge test and evolution. J Investig Allergol Clin Immunol 2003;13:155-161.
86. Torres MJ, Blanca M, Fernandez J, Romano A, Weck A, Aberer W et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003;58:961-972.
87. Baldo BA, Pham NH, Zhao Z. Chemistry of drug allergenicity. Curr Opin Allergy Clin Immunol 2001;1:327-335.
88. Torres MJ, Blanca M. Importance of skin testing with major and minor determinants of benzylpenicillin in the diagnosis of allergy to betalactams. Statement from the European Network for Drug Allergy concerning AllergoPen withdrawal. Allergy 2006;61:910-911.
89. Rodriguez-Bada JL, Montanez MI, Torres MJ, Mayorga C, Canto G, Perez-Inestrosa E et al. Skin testing for immediate hypersensitivity to betalactams: comparison between two commercial kits. Allergy 2006;61:947-951.
90. Sanz ML, Garcia BE, Prieto I, Tabar A, Oehling A. Specific IgE determination in the diagnosis of beta-lactam allergy. J Investig Allergol Clin Immunol 1996;6:89-93.
91. Garcia JJ, Blanca M, Moreno F, Vega JM, Mayorga C, Fernandez J et al. Determination of IgE antibodies to the benzylpenicilloyl determinant: a comparison of the sensitivity and specificity of three radio allergo sorbent test methods. J Clin Lab Anal 1997;11:251-257.
92. Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL et al. Clinical evaluation of Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001;56:862-870.
93. Torres MJ, Mayorga C, Cornejo-Garcia JA, Romano A, Blanca M. IgE antibodies to penicillin in skin test negative patients. Allergy 2002;57:965.
94. Torres MJ, Padial A, Mayorga C, Fernandez T, Sanchez-Sabate E, Cornejo-Garcia JA et al. The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams. Clin Exp Allergy 2004;34:1768-1775.
95. Knudsen JD, Pedersen M. IgE-mediated reaction to vancomycin and teicoplanin after treatment with vancomycin. Scand J Infect Dis 1992;24:395-396.
96. Khurana C, de Belder MA. Red-man syndrome after vancomycin: potential cross-reactivity with teicoplanin. Postgrad Med J 1999;75:41-43.
97. Sivagnanam S, Deleu D. Red man syndrome. Crit Care 2003;7:119-120.
98. Polk RE. Anaphylactoid reactions to glycopeptide antibiotics. J Antimicrob Chemother 1991;27(Suppl. B):17-29.
99. Anne' S, Middleton E Jr, Reisman RE. Vancomycin anaphylaxis and successful desensitization. Ann Allergy 1994;73:402-404.
100. Wazny LD, Daghigh B. Desensitization protocols for vancomycin hypersensitivity. Ann Pharmacother 2001;35:1458-1464.
101. Wood MJ. Comparative safety of teicoplanin and vancomycin. J Chemother 2000;12(Suppl. 5):21-25.
102. Manfredi M, Severino M, Testi S, Macchia D, Ermini G, Pichler WJ et al. Detection of specific IgE to quinolones. J Allergy Clin Immunol 2004;113:155-160.
103. Scherer K, Bircher AJ. Hypersensitivity reactions to fluoroquinolones. Curr Allergy Asthma Rep 2005;5:15-21.
104. Mori K, Maru C, Takasuna K. Characterization of histamine release induced by fluoroquinolone antibacterial agents in-vivo and in-vitro. J Pharm Pharmacol 2000;52:577-584.
105. Mori K, Maru C, Takasuna K, Furuhama K. Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent. Eur J Pharmacol 2000;394:51-55.
106. Tilles SA, Slatore CG. Hypersensitivity reactions to non-beta-lactam antibiotics. Clin Rev Allergy Immunol 2003; 24:221-228.
107. Sprung J, Schedewie HK, Kampine JP. Intraoperative anaphylactic shock after bacitracin irrigation. Anesth Analg 1990;71:430-433.
108. Cardot E, Tillie-Leblond I, Jeannin P, Facon A, Breuil K, Patte F et al. Anaphylactic reaction to local administration of rifamycin SV. J Allergy Clin Immunol 1995;95(1 Pt 1):1-7.
109. Blas M, Briesacher KS, Lobato EB. Bacitracin irrigation: a cause of anaphylaxis in the operating room. Anesth Analg 2000;91:1027-1028.
110. Davison DC. Intravenous anaesthesia in modern surgery (sodium-pentothaloxygen). Curr Res Anaesth Analg 1943;22:52-56.
111. Clarke RS. Adverse effects of intravenously administered drugs used in anaesthetic practice. Drugs 1981;22:26-41.
112. Evans JM, Keogh JA. Adverse reactions to intravenous anaesthetic induction agents. Br Med J 1977;2:735-736.
113. Harle DG, Baldo BA, Smal MA, Wajon P, Fisher MM. Detection of thiopentone-reactive IgE antibodies following anaphylactoid reactions during anaesthesia. Clin Allergy 1986;16:493-498.
114. Laxenaire MC, Mata-Bermejo E, Moneret-Vautrin DA, Gueant JL. Lifethreatening anaphylactoid reactions to propofol (Diprivan). Anesthesiology 1992;77:275-280.
115. Hofer KN, McCarthy MW, Buck ML, Hendrick AE. Possible anaphylaxis after propofol in a child with food allergy. Ann Pharmacother 2003;37:398-401.
116. Marone G, Stellato C, Mastronardi P, Mazzarella B. Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. Ann Fr Anesth Reanim 1993;12:116-125.
117. Blunk JA, Schmelz M, Zeck S, Skov P, Likar R, Koppert W. Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin. Anesth Analg 2004;98:364-370.
118. Prieto-Lastra L, Iglesias-Cadarso A, Reano-Martos MM, Perez-Pimiento A, Rodriguez-Cabreros MI, Garcia-Cubero A. Pharmacological stimuli in asthma/urticaria. Allergol Immunopathol (Madr) 2006;34:224-227.
119. Stellato C, Cirillo R, de Paulis A, Casolaro V, Patella V, Mastronardi P et al. Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. Anesthesiology 1992;77:932-940.
120. Forsythe P, Ennis M. Clinical consequences of mast cell heterogeneity. Inflamm Res 2000;49:147-154.
121. Levy JH, Rockoff MA. Anaphylaxis to meperidine. Anesth Analg 1982;61:301-303.
122. Bennett MJ, Anderson LK, McMillan JC, Ebertz JM, Hanifin JM, Hirshman CA. Anaphylactic reaction during anaesthesia associated with positive intradermal skin test to fentanyl. Can Anaesth Soc J 1986;33:75-78.
123. Harle DG, Baldo BA, Coroneos NJ, Fisher MM. Anaphylaxis following administration of papaveretum. Case report: Implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant. Anesthesiology 1989;71:489-494.
124. Baldo BA, Fisher MM. Diagnosis of IgE-dependent anaphylaxis to neuromuscular blocking drugs, thiopentone and opioids. Ann Fr Anesth Reanim 1993;12:173-181.
125. Codreanu F, Morisset M, Kanny G, Moneret-Vautrin DA. Allergy to pholcodine: first case documented by oral challenge. Allergy 2005;60:544-545.
126. Florvaag E, Johansson SG, Oman H, Harboe T, Nopp A. Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study. Allergy 2006;61:49-55.
127. Baumann TJ. Analgesic selection when the patient is allergic to codeine. Clin Pharm 1991;10:658.
128. Nasser SM, Ewan PW. Opiate-sensitivity: clinical characteristics and the role of skin prick testing. Clin Exp Allergy 2001;31:1014-1020.
129. Namazy JA, Simon RA. Sensitivity to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol 2002;89:542-550.
130. Stevenson DD. Aspirin and NSAID sensitivity. Immunol Allergy Clin North Am 2004;24:491-505.
131. Mastalerz L, Setkowicz M, Sanak M, Szczeklik A. Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma. J Allergy Clin Immunol 2004;113:771-775.
132. Viola M, Quaratino D, Gaeta F, Caringi M, Valluzzi R, Caruso C et al. Celecoxib tolerability in patients with hypersensitivity (mainly cutaneous reactions) to nonsteroidal anti-inflammatory drugs. Int Arch Allergy Immunol 2005;137:145-150.
133. Himly M, Jahn-Schmid B, Pittertschatscher K, Bohle B, Grubmayr K, Ferreira F et al. IgEmediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. J Allergy Clin Immunol 2003;111:882-888.
134. Bochenek G, Niz AE, Szczeklik A. Testing for aspirin hypersensitivity. Allergy 2002;57:562-565.
135. Kubota Y, Imayama S, Toshitani A, Miyahara H, Tanahashi T, Uemura Y et al. Sulfidoleukotriene release test (CAST) in hypersensitivity to nonsteroidal anti-inflammatory drugs. Int Arch Allergy Immunol 1997;114:361-366.
136. Lebel B, Messaad D, Kvedariene V, Rongier M, Bousquet J, Demoly P. Cysteinyl-leukotriene release test (CAST) in the diagnosis of immediate drug reactions. Allergy 2001;56:688-692.
137. Pierzchalska M, Mastalerz L, Sanak M, Zazula M, Szczeklik A. A moderate and unspecific release of cysteinyl leukotrienes by aspirin from peripheral blood leucocytes precludes its value for aspirin sensitivity testing in asthma. Clin Exp Allergy 2000;30:1785-1791.
138. Gamboa PM, Sanz ML, Caballero MR, Antepara I, Urrutia I, Jauregui I et al. Use of CD63 expression as a marker of in vitro basophil activation and leukotriene determination in metamizol allergic patients. Allergy 2003;58:312-317.
139. Gamboa P, Sanz ML, Caballero MR, Urrutia I, Antepara I, Esparza R et al. The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome. Clin Exp Allergy 2004;34:1448-1457.
140. Bachmeyer C, Vermeulen C, Habki R, Blay F, Leynadier F. Acetaminophen (paracetamol)-induced anaphylactic shock. South Med J 2002;95:759-760.
141. Boussetta K, Ponvert C, Karila C, Bourgeois ML, Blic J, Scheinmann P. Hypersensitivity reactions to paracetamol in children: a study of 25 cases. Allergy 2005;60:1174-1177.
142. Galindo PA, Borja J, Mur P, Feo F, Gomez E, Garcia R. Anaphylaxis to paracetamol. Allergol Immunopathol (Madr) 1998;26:199-200.
143. de Paramo BJ, Gancedo SQ, Cuevas M, Camo IP, Martin JA, Cosmes EL. Paracetamol (acetaminophen) hypersensitivity. Ann Allergy Asthma Immunol 2000;85(6 Pt 1):508-511.
144. Freeman MK. Fatal reaction to haemaccel. Anaesthesia 1979;34:341- 343.
145. Ring J. Anaphylactoid reactions to intravenous solutions used for volume substitution. Clin Rev Allergy 1991;9:397-414.
146. Sakaguchi M, Nakayama T, Inouye S. Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines. J Allergy Clin Immunol 1996;98(6 Pt 1):1058-1061.
147. Wahl R, Kleinhans D. IgE-mediated allergic reactions to fruit gums and investigation of cross-reactivity between gelatine and modified gelatinecontaining products. Clin Exp Allergy 1989;19:77-80.
148. Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103(2 Pt 1):200-202.
149. Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allergy Clin Immunol 1999;103(2 Pt 1):321-325.
150. Nakayama T, Aizawa C. Change in gelatin content of vaccines associated with reduction in reports of allergic reactions. J Allergy Clin Immunol 2000;106:591-592.
151. Laxenaire MC, Charpentier C, Feldman L. [Anaphylactoid reactions to colloid plasma substitutes: incidence, risk factors, mechanisms. A French multicenter prospective study]. Ann Fr Anesth Reanim 1994;13:301-310.
152. Vervloet D, Senft M, Dugue P, Arnaud A, Charpin J. Anaphylactic reactions to modified fluid gelatins. J Allergy Clin Immunol 1983;71:535-540.
153. Pepys J, Pepys EO, Baldo BA, Whitwam JG. Anaphylactic/anaphylactoid reactions to anaesthetic and associated agents. Skin prick tests in aetiological diagnosis. Anaesthesia 1994;49:470-475.
154. Apostolou E, Deckert K, Puy R, Sandrini A, de Leon MP, Douglass JA et al. Anaphylaxis to Gelofusine confirmed by in vitro basophil activation test: a case series. Anaesthesia 2006;61:264-268.
155. Bothner U, Georgieff M, Vogt NH. Assessment of the safety and tolerance of 6% hydroxyethyl starch (200/0.5) solution: a randomized, controlled epidemiology study. Anesth Analg 1998;86:850-855.
156. Treib J, Baron JF, Grauer MT, Strauss RG. An international view of hydroxyethyl starches. Intensive Care Med 1999;25:258-268.
157. Wiedermann CJ. Hydroxyethyl starch-can the safety problems be ignored? Wien Klin Wochenschr 2004;116:583-594.
158. Ebo DG, Schuerwegh A, Stevens WJ. Anaphylaxis to starch. Allergy 2000;55:1098-1099.
159. Dieterich HJ, Kraft D, Sirtl C, Laubenthal H, Schimetta W, Polz W et al. Hydroxyethyl starch antibodies in humans: incidence and clinical relevance. Anesth Analg 1998;86:1123-1126.
160. Hedin H, Richter W, Messmer K, Renck H, Ljungstrom KG, Laubenthal H. Incidence, pathomechanism and prevention of dextran-induced anaphylactoid/ anaphylactic reactions in man. Dev Biol Stand 1980;48:179-189.
161. Ljungstrom KG, Willman B, Hedin H. Hapten inhibition of dextran anaphylaxis. Nine years of post-marketing surveillance of dextran 1. Ann Fr Anesth Reanim 1993;12:219-222.
162. Zinderman CE, Landow L, Wise RP. Anaphylactoid reactions to Dextran 40 and 70: reports to the United States Food and Drug Administration, 1969 to 2004. J Vasc Surg 2006;43:1004-1009.
163. Berg EM, Fasting S, Sellevold OF. Serious complications with dextran-70 despite hapten prophylaxis. Is it best avoided prior to delivery? Anaesthesia 1991;46:1033-1035.
164. Bircher AJ, Hedin H, Berglund A. Probable grade IV dextran-induced anaphylactic reaction despite hapten inhibition. J Allergy Clin Immunol 1995;95:633-634.
165. Leach SR. Cardiovascular collapse following infusion of 5% albumin. AANA J 1991;59:592-594.
166. Smith SJ, Geha D, Alston TA. Egg allergy and blood products: you say albumen, I say albumin. Anesthesiology 2003;98:1304-1305.
167. Krautheim AB, Jermann TH, Bircher AJ. Chlorhexidine anaphylaxis: case report and review of the literature. Contact Dermatitis 2004;50:113-116.
168. Ebo DG, Stevens WJ, Bridts CH, Matthieu L. Contact allergic dermatitis and life-threatening anaphylaxis to chlorhexidine. J Allergy Clin Immunol 1998;101(1 Pt 1):128-129.
169. Nishioka K, Doi T, Katayama I. Histamine release in contact urticaria. Contact Dermatitis 1984;11:191.
170. Pham NH, Weiner JM, Reisner GS, Baldo BA. Anaphylaxis to chlorhexidine. Case report. Implication of immunoglobulin E antibodies and identification of an allergenic determinant. Clin Exp Allergy 2000;30:1001-1007.
171. Kroigaard M, Garvey LH, Menne T, Husum B. Allergic reactions in anaesthesia: are suspected causes confirmed on subsequent testing? Br J Anaesth 2005;95:468-471.
172. Ebo DG, Bridts CH, Stevens WJ. IgEmediated anaphylaxis from chlorhexidine: diagnostic possibilities. Contact Dermatitis 2006;55:301- 302.
173. Waran KD, Munsick RA. Anaphylaxis from povidone-iodine. Lancet 1995;345:1506.
174. Lopez Saez MP, De Barrio M, Zubeldia JM, Prieto A, Olalde S, Baeza ML. Acute IgE-mediated generalized urticaria-angioedema after topical application of povidone-iodine. Allergol Immunopathol (Madr) 1998;26:23-26.
175. Le Pabic F, Sainte-Laudy J, Blanchard N, Moneret-Vautrin DA. First case of anaphylaxis to iodinated povidone. Allergy 2003;58:826-827.
176. Adachi A, Fukunaga A, Hayashi K, Kunisada M, Horikawa T. Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine. Contact Dermatitis 2003;48:133-136.
177. Pedrosa C, Costa H, Oliveira G, Romariz J, Praca F. Anaphylaxis to povidone in a child. Pediatr Allergy Immunol 2005;16:361-362.
178. Eggleston ST, Lush LW. Understanding allergic reactions to local anesthetics. Ann Pharmacother 1996;30:851-857.
179. Chen AH. Toxicity and allergy to local anesthesia. J Calif Dent Assoc 1998;26:683-692.
180. Solensky R. Drug hypersensitivity. Med Clin North Am 2006;90:233- 260.
181. Gall H, Kaufmann R, Kalveram CM. Adverse reactions to local anesthetics: analysis of 197 cases. J Allergy Clin Immunol 1996;97:933-937.
182. Fisher MM, Bowey CJ. Alleged allergy to local anaesthetics. Anaesth Intensive Care 1997;25:611-614.
183. Baluga JC, Casamayou R, Carozzi E, Lopez N, Anale R, Borges R et al. Allergy to local anaesthetics in dentistry. Myth or reality? Allergol Immunopathol (Madr) 2002;30:14-19.
184. Chernow B, Balestrieri F, Ferguson CD, Terezhalmy GT, Fletcher JR, Lake CR. Local dental anesthesia with epinephrine. Minimal effects on the sympathetic nervous system or on hemodynamic variables. Arch Intern Med 1983;143:2141-2143.
185. Simon RA. Adverse reactions to drug additives. J Allergy Clin Immunol 1984;74(4 Pt 2):623-630.
186. Dooms-Goossens A, de Alam AG, Degreef H, Kochuyt A. Local anesthetic intolerance due to metabisulfite. Contact Dermatitis 1989;20:124-126.
187. Cuesta-Herranz J, de las HM, Fernandez M, Lluch M, Figueredo E, Umpierrez A et al. Allergic reaction caused by local anesthetic agents belonging to the amide group. J Allergy Clin Immunol 1997;99:427-428.
188. Kakuyama M, Toda H, Osawa M, Fukuda K. An adverse effect of carboxymethylcellulose in lidocaine jelly. Anesthesiology 1999;91:1969.
189. Schatz M. Skin testing and incremental challenge in the evaluation of adverse reactions to local anesthetics. J Allergy Clin Immunol 1984;74(4 Pt 2):606-616.
190. Wasserfallen JB, Frei PC. Long-term evaluation of usefulness of skin and incremental challenge tests in patients with history of adverse reaction to local anesthetics. Allergy 1995;50:162-165.
191. Weiss ME, Adkinson NF Jr. Allergy to protamine. Clin Rev Allergy 1991;9:339-355.
192. Ravi R, Frost EA. Cardiac surgery in patients with protamine allergy. Heart Dis 1999;1:289-294.
193. Park KW. Protamine and protamine reactions. Int Anesthesiol Clin 2004;42:135-145.
194. Weiler JM, Gellhaus MA, Carter JG, Meng RL, Benson PM, Hottel RA et al. A prospective study of the risk of an immediate adverse reaction to protamine sulfate during cardiopulmonary bypass surgery. J Allergy Clin Immunol 1990;85:713-719.
195. Gottschlich GM, Gravlee GP, Georgitis JW. Adverse reactions to protamine sulfate during cardiac surgery in diabetic and non-diabetic patients. Ann Allergy 1988;61:277-281.
196. Levy JH, Schwieger IM, Zaidan JR, Faraj BA, Weintraub WS. Evaluation of patients at risk for protamine reactions. J Thorac Cardiovasc Surg 1989;98:200-204.
197. Adourian U, Shampaine EL, Hirshman CA, Fuchs E, Adkinson NF Jr. High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiology 1993;78:368-372.
198. Horrow JC, Pharo GH, Levit LS, Freeland C. Neither skin tests nor serum enzyme-linked immunosorbent assay tests provide specificity for protamine allergy. Anesth Analg 1996;82:386-389.
199. Bottio T, Pittarello G, Bonato R, Fagiolo U, Gerosa G. Life-threatening anaphylactic shock caused by porcine heparin intravenous infusion during mitral valve repair. J Thorac Cardiovasc Surg 2003;126:1194-1195.
200. Ebo DG, Haine SE, Hagendorens MM, Bridts CH, Conraads VM, Vorlat A et al. Hypersensitivity to nadroparin calcium: case report and review of the literature. Clin Drug Invest 2004;24:421-426.
201. Royston D, van Haaften N, De Vooght P. Aprotinin; friend or foe? A review of recent medical literature. Eur J Anaesthesiol 2007;24:6-14.
202. Dietrich W, Spath P, Zuhlsdorf M, Dalichau H, Kirchhoff PG, Kuppe H et al. Anaphylactic reactions to aprotinin reexposure in cardiac surgery: relation to antiaprotinin immunoglobulin G and E antibodies. Anesthesiology 2001;95:64-71.
203. Beierlein W, Scheule AM, Dietrich W, Ziemer G. Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions. Ann Thorac Surg 2005;79:741-748.
204. Jaquiss RD, Ghanayem NS, Zacharisen MC, Mussatto KA, Tweddell JS, Litwin SB. Safety of aprotinin use and re-use in pediatric cardiothoracic surgery. Circulation 2002;106(12 Suppl. 1):S90-S94.
205. Shirai T, Shimota H, Chida K, Sano S, Takeuchi Y, Yasueda H. Anaphylaxis to aprotinin in fibrin sealant. Intern Med 2005;44:1088-1089.
206. Ebo DG, Goossens S, Opsomer F, Bridts CH, Stevens WJ. Flow-assisted diagnosis of anaphylaxis to hyaluronidase. Allergy 2005;60:1333-1334.
207. Slater RM, Bowles BJ, Pumphrey RS. Anaphylactoid reaction to oxytocin in pregnancy. Anaesthesia 1985;40:655-656.
208. Emmott RS. Recurrent anaphylactoid reaction during caesarean section. Anaesthesia 1990;45:62.
209. Thomas JS, Koh SH, Cooper GM. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. Br J Anaesth 2007;98:116-119.
210. Kopp WL. Anaphylaxis from alphazurine 2G during lymphography. JAMA 1966;198:668-669.
211. Woltsche-Kahr I, Komericki P, Kranke B, Brabek E, Horn M, Schuller-Petrovic S et al. Anaphylactic shock following peritumoral injection of patent blue in sentinel lymph node biopsy procedure. Eur J Surg Oncol 2000;26:313-314.
212. Wohrl S, Focke M, Hinterhuber G, Stingl G, Binder M. Near-fatal anaphylaxis to patent blue V. Br J Dermatol 2004;150:1037-1038.
213. Ebo DG, Wets RD, Spiessens TK, Bridts CH, Stevens WJ. Flow-assisted diagnosis of anaphylaxis to patent blue. Allergy 2005;60:703-704.
214. Longnecker SM, Guzzardo MM, Van Voris LP. Life-threatening anaphylaxis following subcutaneous administration of isosulfan blue 1%. Clin Pharm 1985;4:219-221.
215. Leong SP, Donegan E, Heffernon W, Dean S, Katz JA. Adverse reactions to isosulfan blue during selective sentinel lymph node dissection in melanoma. Ann Surg Oncol 2000;7:361-366.
216. Cimmino VM, Brown AC, Szocik JF, Pass HA, Moline S, De SK et al. Allergic reactions to isosulfan blue during sentinel node biopsy - a common event. Surgery 2001;130:439-442.
217. Efron P, Knudsen E, Hirshorn S, Copeland EM. Anaphylactic reaction to isosulfan blue used for sentinel node biopsy: case report and literature review. Breast J 2002;8:396-399.
218. Scherer K, Studer W, Figueiredo V, Bircher AJ. Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes. Ann Allergy Asthma Immunol 2006;96:497- 500.
219. Naitoh J, Fox BM. Severe hypotension, bronchospasm, and urticaria from intravenous indigo carmine. Urology 1994;44:271-272.
220. Gousse AE, Safir MH, Madjar S, Ziadlourad F, Raz S. Life-threatening anaphylactoid reaction associated with indigo carmine intravenous injection. Urology 2000;56:508.
221. Rzymski P, Wozniak J, Opala T, Wilczak M, Sajdak S. Anaphylactic reaction to methylene blue dye after laparoscopic chromopertubation. Int J Gynaecol Obstet 2003;81:71-72.
222. Dewachter P, Mouton-Faivre C, Trechot P, Lleu JC, Mertes PM. Severe anaphylactic shock with methylene blue instillation. Anesth Analg 2005;101:149-150.
223. Thevarajah S, Huston TL, Simmons RM. A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph node biopsy for breast cancer. Am J Surg 2005;189:236-239.
224. Rose M, Fisher M. Rocuronium: high risk for anaphylaxis? Br J Anaesth 2001;86:678-682.
225. Harle DG, Baldo BA, Fisher MM. Immunoassays employing substituted ammonium compounds other than neuromuscular blocking drugs to increase the detection of IgE antibodies to these drugs. Mol Immunol 1990;27:1039- 1045.
226. Leynadier F, Wessel F. [Skin tests for diagnosis of hypersensitivity to colloidal plasma substitutes]. Ann Fr Anesth Reanim 2002;21(Suppl. 1):121-122.
227. Ebo DG, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ. Allergic reactions occurring during anaesthesia: diagnostic approach. Acta Clin Belg 2004;59:34-43.