Lithium-induced sinus node disease at therapeutic concentrations: Linking lithium-induced blockade of sodium channels to impaired pacemaker activity

Canadian Journal of Cardiology

Volumn 23, Issue 3, 2007, Pages 229-232

  Oudit, Gavin Y ^a,b   Korley, Victoria ^a   Backx, Peter H ^b   Dorian, Paul ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiac sodium channels; Lithium; Sinus node dysfunction

Indexed keywords

ATROPINE; LITHIUM CARBONATE; SODIUM CHANNEL; ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; ARTIFICIAL HEART PACEMAKER; BIPOLAR DISORDER; BLOOD ANALYSIS; CASE REPORT; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ELECTROCARDIOGRAPHY; EXERCISE TEST; FLUID RESUSCITATION; HUMAN; MALE; SINUS ARREST; SINUS NODE; SUICIDAL IDEATION; SUICIDE ATTEMPT; THORAX RADIOGRAPHY; THYROID FUNCTION TEST; TRANSTHORACIC ECHOCARDIOGRAPHY; VAGUS TONE; BLOOD; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MIDDLE AGED; SICK SINUS SYNDROME;

ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HUMANS; LITHIUM CARBONATE; MALE; MIDDLE AGED; PACEMAKER, ARTIFICIAL; SICK SINUS SYNDROME; SODIUM CHANNELS;

EID: 34247195008     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0828-282X(07)70750-X     Document Type: Letter

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