Safety evaluation of a milk basic protein fraction

Food and Chemical Toxicology

Volumn 45, Issue 7, 2007, Pages 1301-1307

  Kruger, C L ^a   Marano, K M ^a   Morita, Y ^b   Takada, Y ^b   Kawakami, H ^b   Kobayashi, T ^b   Sunaga, M ^c   Furukawa, M ^c   Kawamura, K ^c  

^a ENVIRON INTERNATIONAL CORPORATION   (United States)

^b SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

^c Safety Research Institute for Chemical Compounds Co Ltd   (Japan)

Author keywords

Ames assay; Food; Milk basic protein; Safety; Subchronic toxicity; Teratology

Indexed keywords

CALCIUM; MILK PROTEIN;

ACUTE TOXICITY; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE METABOLISM; CHRONIC TOXICITY; CONTROLLED STUDY; FEMALE; FOOD SAFETY; MALE; MILK; MUTATION; NONHUMAN; OSTEOLYSIS; RAT; TERATOLOGY; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CELL FRACTIONATION; CONSUMER PRODUCT SAFETY; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; FOOD SUPPLY; LIVER; MALE; MATERNAL EXPOSURE; MILK PROTEINS; MUTAGENS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RATS; RATS, INBRED STRAINS; SALMONELLA TYPHIMURIUM; TERATOGENS; TOXICITY TESTS;

EID: 34247152462     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.01.017     Document Type: Article

References (15)

1. Kato K., Toba Y., Matsuyama H., Yamamura J., Matsuoka Y., Kawakami H., Itabashi A., Kumegawa M., Aoe S., and Takada Y. Milk basic protein enhances the bone strength in ovariectomized rats. J. Food Biochem. 24 (2000) 467-476
2. Matsuoka Y., Serizawa A., Yoshioka T., Yamamura J., Morita Y., Kawakami H., Toba Y., Takada Y., and Kumegawa M. Cystatin C in Milk Basic Protein (MBP) and its inhibitory effect on bone resorption in vitro. Biosci. Biotechnol. Biochem. 66 (2002) 2531-2536
3. Ministry of Agriculture, Forestry and Fisheries, 2002a. Statistics on Milk and Dairy Products.
4. Ministry of Agriculture, Forestry and Fisheries, 2002b. Food Balance Sheet.
5. Ministry of Education, Culture, Sports, Science and Technology, Ministry of Health, Labour and Welfare, and Ministry of Agriculture, Forestry and Fisheries, 2000. Dietary Guidelines.
6. Ministry of Health, Labour and Welfare, 2000. Health Japan 21.
7. Takada Y., Aoe S., and Kumegawa M. Whey protein stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 223 (1996) 445-449
8. Takada Y., Kobayashi N., Kato K., Matsuyama H., Yahiro M., and Aoe S. Effects of whey protein on calcium and bone metabolism in ovariectomized rats. J. Nutr. Sci. Vitaminol. 43 (1997) 199-210
9. Takada Y., Kobayashi N., Matsuyama H., Kato K., Yamamura J., Yahiro M., Kumegawa M., and Aoe S. Whey protein suppresses the osteoclast-mediated bone resorption and osteoclast cell formation. Int. Dairy J. 7 (1997) 821-825
10. Takada Y., Matsuyama H., Kato K., Kobayashi N., Yamamura J., Yahiro M., and Aoe S. Milk whey protein enhances the bone breaking force in ovariectomized rats. Nutr. Res. 17 (1997) 1709-1720
11. Takada Y., Toba Y., Aoe S., Kumegawa M., and Itabashi A. Milk Basic Protein (MBP) promotes bone formation and suppresses bone resorption. In: Burchkhardt P., Dawson-Hughes B., and Heaney R.P. (Eds). Nutritional Aspects of Osteoporosis (2001), Academic Press, San Diego, CA (Chapter 14)
12. Toba Y., Takada Y., Yamamura J., Tanaka M., Matsuoka Y., Kawakami H., Itabashi A., Aoe S., and Kumegawa M. Milk basic protein: a novel protective function of milk against osteoporosis. Bone 27 (2000) 403-408
13. United States Department of Agriculture (USDA) (2005) Dietary guidelines for Americans, 2005. Retrieved from: http://www.health.gov/dietaryguidelines/dga2005/document/.
14. Yamamura J., Takada Y., Goto M., Kumegawa M., and Aoe S. High mobility group-like protein in bovine milk stimulates the proliferation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 261 (1999) 113-117
15. Yamamura J., Takada Y., Goto M., Kumegawa M., and Aoe S. Bovine milk kininogen fragment 1 · 2 promotes the proliferation of osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 269 (2000) 628-632