Antitubercular activity of novel substituted 4, 5-dihydro-1H-1-pyrazolylmethanethiones

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 2, 2007, Pages 183-189

  Ali, Mohamed Ashraf ^a   Yar, Mohammad Shahar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

INH resistant mycobacterium tuberculosis and antitubercular agent; Isoniazid; Isothiocyanate; Pyrazoline

Indexed keywords

1 (4 HYDROXY 3 METHYLPHENYL) 3 (3",4" DIMETHOXYPHENYL) 2 PROPEN 1 ONE; 1 (4' HYDROXY 3' METHYLPHENYL) 3 (4" CHLOROPHENYL) 2 PROPEN 1 ONE; 1 (4' HYDROXY 3' METHYLPHENYL) 3 (4" DIMETHYLAMINOPHENYL) 2 PROPEN 1 ONE; 1 (4' HYDROXY 3' METHYLPHENYL) 3 (4" METHOXYPHENYL) 2 PROPEN 1 ONE; 1 (4' HYDROXY 3' METHYLPHENYL) 3 PHENYL 2 PROPEN 1 ONE; 2 CHLOROANILINO 5 (2,6 DICHLOROPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; 4 [5 (2' CHLOROPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (2' FURYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (2',6' DICHLOROPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (3' NITROPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (3',4' DIMETHOXYPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (3',4',5' TRIMETHOXYPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (4' CHLOROPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (4' DIMETHYLAMINOPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (4' FLUOROPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; 4 [5 (4' METHOXYPHENYL) 4,5 DIHYDRO 1H 3 PYRAZOLYL] 2 METHYLPHENOL; ANILINO 5 (3,4 DIMETHOXYPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 (3,4,5 TRIMETHOXYPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 (4 CHLOROPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 (4 DIMETHYLAMINOPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 (4 FLUOROPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 (4 METHOXYPHENYL) 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; ANILINO 5 PHENYL 3 (4 HYDROXY 3 METHYLPHENYL) 4,5 DIHYDRO 1H 1 PYRAZOLYLMETHANETHIONE; CHALCONE; HYDRAZINE; ISONIAZID; ISOTHIOCYANIC ACID; PYRAZOLINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RADIOMETRY;

ANTITUBERCULAR AGENTS; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIONES;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34247148076     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360601072437     Document Type: Article

References (11)

1. Bloom, BR and Murray, CJL (1992) Tuberculosis: Commentary on a re-emergent killer. Science, 257, p. 1055.
2. Barnes, PF, Blotch, AB, Davidson, PT and Snider Jr, DE (1991) Tuberculosis in patients with immuno-deficiency virus infection. N Engl J Med, 324, p. 1644.
3. Sbarbaro, JA (1997) Multidrug-resistant tuberculosis. It is time to focus on the private sector of medicine. Chest, 111, p. 1149.
4. Fujiwara, PI, Cook, SV, Rutherford, CM, Crawford, JT, Glickman, SE, Kreiswirth, BN, Sachdev, PS, Osahan, SS, Ebrahimzadeh, A. and Frieden, TR (1997) A continuing survey of drug-resistant tuberculosis. Arch Intern Med, 157, p. 531.
5. Schaberg, T., Gloger, G., Reichert, B., Mauch, H. and Lode, H. (1996) Resistant lung tuberculosis in Berlin 1987-1993. Pneumologie, 50, p. 21.
6. Kucukguzel, SG and Rollas, S. (2002) Synthesis, characterization of novel coupling products and 4-arylhydrazono-2-pyrazoline-5-ones as potential antimycobacterial agents. Farmaco, 57, p. 583.
7. Shaharyar, M., Siddiqui, AA, Ali, MA, Sriram, D. and Yogeeswari, P. (2006) Synthesis and in vitro antimycobacterial activity of N(1)-nicotinoyl-3-(4′-hydroxy-3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines. Bioorg Med Chem Lett, 16, pp. 3947-3949.
8. Nauduri, D. and Reddy, GB (1998) Antibacterials and antimycotics: Part 1: Synthesis and activity of 2-pyrazoline derivatives. Chem Pharm Bull (Tokyo), 46:8, pp. 1254-1260.
9. Santilli, AA, Kim, DH and Gregory, FJ (1975) Antitubercular activity of substituted 5-oxo-1-thiocarbamoyl-3-pyrazoline-4-alkanoic acid derivatives. J Pharm Sci., 64:6, pp. 1057-1058.
10. Collins, L. and Frazblau, SG (1997) Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium Antimicrob. Agents Chemother, 41, p. 1004.
11. Gundersen, LL, Nissen-Meyer, J. and Spilsberg, B. (2002) Synthesis and antimycobacterial activity of 6-arylpurines: The requirements for the N-9 substituent in active antimycobacterial purines. J Med Chem, 45, p. 1383.