Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells

Clinical and Experimental Immunology

Volumn 148, Issue 2, 2007, Pages 288-295

  Nielsen, C H ^a,b   Albertsen, L ^a,b   Bendtzen, K ^a   Baslund, B ^a,b  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Apoptosis; CD4+ T cells; Methotrexate

Indexed keywords

ANTIGEN; CASPASE 3; METHOTREXATE; MITOGENIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHYTOHEMAGGLUTININ; PROTEIN BCL 2; TETANUS TOXOID;

APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CD4+ T LYMPHOCYTE; CELL DIVISION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

APOPTOSIS; CASPASE 3; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLIC ACID; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; METHOTREXATE; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 34247147677     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03335.x     Document Type: Article

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