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Volumn 51, Issue 1, 2007, Pages 52-58

Latent autoimmune diabetes in adults (LADA): Usefulness of anti-GAD antibody titers and benefit of early insulinization

Author keywords

GADA titers; Insulinization; LADA

Indexed keywords

ANTIDIABETIC AGENT; AUTOANTIBODY; BIOLOGICAL MARKER; C PEPTIDE; GLUTAMATE DECARBOXYLASE; INSULIN;

EID: 34247146490     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302007000100009     Document Type: Article
Times cited : (25)

References (42)
  • 1
    • 0035430208 scopus 로고    scopus 로고
    • Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): Definition, characterization, and potential prevention
    • Pozzilli P, Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): definition, characterization, and potential prevention. Diabetes Care 2001;24:1460-7.
    • (2001) Diabetes Care , vol.24 , pp. 1460-1467
    • Pozzilli, P.1    Di Mario, U.2
  • 2
    • 0031560175 scopus 로고    scopus 로고
    • UKPDS 25: Autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group
    • Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 1997;350:1288-93.
    • (1997) Lancet , vol.350 , pp. 1288-1293
    • Turner, R.1    Stratton, I.2    Horton, V.3    Manley, S.4    Zimmet, P.5    Mackay, I.R.6
  • 3
    • 0041591490 scopus 로고    scopus 로고
    • Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression
    • Hosszufalusi N, Vatay A, Rajczy K, Prohaszka Z, Pozsonyi E, Horvath L, et al. Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression. Diabetes Care 2003;26:452-7.
    • (2003) Diabetes Care , vol.26 , pp. 452-457
    • Hosszufalusi, N.1    Vatay, A.2    Rajczy, K.3    Prohaszka, Z.4    Pozsonyi, E.5    Horvath, L.6
  • 4
    • 0032955251 scopus 로고    scopus 로고
    • Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
    • Tuomi T, Carlsson A, Li H, Isomaa B, Miettinen A, Nilsson A, et al. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 1999;48:150-7.
    • (1999) Diabetes , vol.48 , pp. 150-157
    • Tuomi, T.1    Carlsson, A.2    Li, H.3    Isomaa, B.4    Miettinen, A.5    Nilsson, A.6
  • 5
    • 0032801250 scopus 로고    scopus 로고
    • Chronic complications in patients with slowly progressing autoimmune type 1 diabetes (LADA)
    • Isomaa B, Almgren P, Henricsson M, Taskinen MR, Tuomi T, Groop L, et al. Chronic complications in patients with slowly progressing autoimmune type 1 diabetes (LADA). Diabetes Care 1999;22:1347-53.
    • (1999) Diabetes Care , vol.22 , pp. 1347-1353
    • Isomaa, B.1    Almgren, P.2    Henricsson, M.3    Taskinen, M.R.4    Tuomi, T.5    Groop, L.6
  • 6
    • 9444260938 scopus 로고    scopus 로고
    • Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
    • ADOPT Study Group
    • Zinman B, Kahn SE, Haffner SM, O'Neill MC, Heise MA, Freed MI (ADOPT Study Group). Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe. Diabetes 2004;53:3193-200.
    • (2004) Diabetes , vol.53 , pp. 3193-3200
    • Zinman, B.1    Kahn, S.E.2    Haffner, S.M.3    O'Neill, M.C.4    Heise, M.A.5    Freed, M.I.6
  • 7
    • 0034884628 scopus 로고    scopus 로고
    • Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA)
    • Lohmann T, Kellner K, Verlohren HJ, Krug J, Steindorf J, Scherbaum WA, et al. Titre and combination of ICA and autoantibodies to glutamic acid decarboxylase discriminate two clinically distinct types of latent autoimmune diabetes in adults (LADA). Diabetologia 2001;44:1005-10.
    • (2001) Diabetologia , vol.44 , pp. 1005-1010
    • Lohmann, T.1    Kellner, K.2    Verlohren, H.J.3    Krug, J.4    Steindorf, J.5    Scherbaum, W.A.6
  • 8
    • 0042092541 scopus 로고    scopus 로고
    • What's in a name: Latent autoimmune diabetes of adults, type 1.5, adult-onset, and type 1 diabetes
    • Palmer JP, Hirsch IB. What's in a name: Latent autoimmune diabetes of adults, type 1.5, adult-onset, and type 1 diabetes. Diabetes Care 2003;26:536-8.
    • (2003) Diabetes Care , vol.26 , pp. 536-538
    • Palmer, J.P.1    Hirsch, I.B.2
  • 9
    • 18544379634 scopus 로고    scopus 로고
    • Antibodies to GAD in Japanese patients classified as type 2 diabetes at diagnosis. High titre of GADAb is a predictive marker for early insulin treatment - report of west Japan (Kyushu, Yamaguchi, Osaka) study for GADAb(+) diabetes
    • Takino H, Yamasaki H, Abiru N, Sera Y, Abe T, Kawasaki E, et al. Antibodies to GAD in Japanese patients classified as type 2 diabetes at diagnosis. High titre of GADAb is a predictive marker for early insulin treatment - report of west Japan (Kyushu, Yamaguchi, Osaka) study for GADAb(+) diabetes. Diabet Med 2002;19:730-4.
    • (2002) Diabet Med , vol.19 , pp. 730-734
    • Takino, H.1    Yamasaki, H.2    Abiru, N.3    Sera, Y.4    Abe, T.5    Kawasaki, E.6
  • 10
    • 1942442498 scopus 로고    scopus 로고
    • Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): Preliminary report
    • Maruyama T, Shimada A, Kanatsuka A, Kasuga A, Takei I, Yokoyama J, et al. Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): preliminary report. Ann N Y Acad Sci 2003;1005:362-9.
    • (2003) Ann N Y Acad Sci , vol.1005 , pp. 362-369
    • Maruyama, T.1    Shimada, A.2    Kanatsuka, A.3    Kasuga, A.4    Takei, I.5    Yokoyama, J.6
  • 11
    • 0036268009 scopus 로고    scopus 로고
    • Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus
    • Kobayashi T, Maruyama T, Shimada A, Kasuga A, Kanatsuka A, Takei I, et al. Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitus. Ann N Y Acad Sci 2002;958:117-30.
    • (2002) Ann N Y Acad Sci , vol.958 , pp. 117-130
    • Kobayashi, T.1    Maruyama, T.2    Shimada, A.3    Kasuga, A.4    Kanatsuka, A.5    Takei, I.6
  • 12
    • 21544433791 scopus 로고    scopus 로고
    • Comparison of clinical and laboratory characteristics between adult-onset type 1 diabetes and latent autoimmune diabetes in adults
    • Rosário PW, Reis JS, Amim R, Fagundes TA, Calsolari MR, Silva SC, et al. Comparison of clinical and laboratory characteristics between adult-onset type 1 diabetes and latent autoimmune diabetes in adults. Diabetes Care 2005;28:1803-4.
    • (2005) Diabetes Care , vol.28 , pp. 1803-1804
    • Rosário, P.W.1    Reis, J.S.2    Amim, R.3    Fagundes, T.A.4    Calsolari, M.R.5    Silva, S.C.6
  • 16
    • 0037408360 scopus 로고    scopus 로고
    • Diabetes antibody standardization program: First assay proficiency evaluation
    • Bingley PJ, Bonifacio E, Mueller PW. Diabetes antibody standardization program: First assay proficiency evaluation. Diabetes 2003;52:1128-36.
    • (2003) Diabetes , vol.52 , pp. 1128-1136
    • Bingley, P.J.1    Bonifacio, E.2    Mueller, P.W.3
  • 17
    • 0032896330 scopus 로고    scopus 로고
    • Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas
    • Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 1999;22:818-22.
    • (1999) Diabetes Care , vol.22 , pp. 818-822
    • Emoto, M.1    Nishizawa, Y.2    Maekawa, K.3    Hiura, Y.4    Kanda, H.5    Kawagishi, T.6
  • 18
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000;23:57-63.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3    Bonadonna, R.C.4    Saggiani, F.5    Zenere, M.B.6
  • 19
    • 0023761266 scopus 로고
    • Classification of newly diagnosed diabetic patients as insulin-requiring or non-insulin-requiring based on clinical and biochemical variables
    • Hother-Nielsen O, Faber O, Sorensen NS, Beck-Nielsen H. Classification of newly diagnosed diabetic patients as insulin-requiring or non-insulin-requiring based on clinical and biochemical variables. Diabetes Care 1988;11:531-7.
    • (1988) Diabetes Care , vol.11 , pp. 531-537
    • Hother-Nielsen, O.1    Faber, O.2    Sorensen, N.S.3    Beck-Nielsen, H.4
  • 20
    • 0034457728 scopus 로고    scopus 로고
    • Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA)
    • Carlsson A, Sundkvist G, Groop L, Tuomi T. Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J Clin Endocrinol Metab 2000;85:76-80.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 76-80
    • Carlsson, A.1    Sundkvist, G.2    Groop, L.3    Tuomi, T.4
  • 21
    • 0034920605 scopus 로고    scopus 로고
    • High levels of antigen-specific islet antibodies predict future beta-cell failure in patients with onset of diabetes in adult age
    • Borg H, Gottsater A, Landin-Olsson M, Fernlund P, Sundkvist G. High levels of antigen-specific islet antibodies predict future beta-cell failure in patients with onset of diabetes in adult age. J Clin Endocrinol Metab 2001;86:3032-8.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3032-3038
    • Borg, H.1    Gottsater, A.2    Landin-Olsson, M.3    Fernlund, P.4    Sundkvist, G.5
  • 22
    • 0346266005 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults
    • Li X, Yang L, Zhou Z, Huang G, Yan X. Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults. Chin Med J (Engl) 2003;116:1728-32.
    • (2003) Chin Med J (Engl) , vol.116 , pp. 1728-1732
    • Li, X.1    Yang, L.2    Zhou, Z.3    Huang, G.4    Yan, X.5
  • 23
    • 7944222976 scopus 로고    scopus 로고
    • Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes
    • Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahasi M, et al. Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes. Diabetes Res Clin Pract 2004;66:163-71.
    • (2004) Diabetes Res Clin Pract , vol.66 , pp. 163-171
    • Hamaguchi, K.1    Kimura, A.2    Kusuda, Y.3    Yamashita, T.4    Yasunami, M.5    Takahasi, M.6
  • 25
    • 0029665614 scopus 로고    scopus 로고
    • Antibody to the M(r) 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese
    • Kasuga A, Maruyama T, Ozawa Y, Takei I, Falorni A, Lernmark A, et al. Antibody to the M(r) 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J Autoimmun 1996;9:105-11.
    • (1996) J Autoimmun , vol.9 , pp. 105-111
    • Kasuga, A.1    Maruyama, T.2    Ozawa, Y.3    Takei, I.4    Falorni, A.5    Lernmark, A.6
  • 26
    • 0033105816 scopus 로고    scopus 로고
    • High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients
    • Kasuga A, Maruyama T, Nakamoto S, Ozawa Y, Suzuki Y, Saruta T. High-titer autoantibodies against glutamic acid decarboxylase plus autoantibodies against insulin and IA-2 predicts insulin requirement in adult diabetic patients. J Autoimmun 1999;12:131-5.
    • (1999) J Autoimmun , vol.12 , pp. 131-135
    • Kasuga, A.1    Maruyama, T.2    Nakamoto, S.3    Ozawa, Y.4    Suzuki, Y.5    Saruta, T.6
  • 27
    • 18744432654 scopus 로고    scopus 로고
    • Ehime Study. Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study)
    • Takeda H, Kawasaki E, Shimizu I, Konoue E, Fujiyama M, Murao S, et al;Ehime Study. Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study). Diabetes Care 2002;25:995-1001.
    • (2002) Diabetes Care , vol.25 , pp. 995-1001
    • Takeda, H.1    Kawasaki, E.2    Shimizu, I.3    Konoue, E.4    Fujiyama, M.5    Murao, S.6
  • 28
    • 0036266123 scopus 로고    scopus 로고
    • A 12-year prospective study of the relationship between islet antibodies and beta-cell function at and after the diagnosis in patients with adult-onset diabetes
    • Borg H, Gottsater A, Fernlund P, Sundkvist G. A 12-year prospective study of the relationship between islet antibodies and beta-cell function at and after the diagnosis in patients with adult-onset diabetes. Diabetes 2002;51:1754-62.
    • (2002) Diabetes , vol.51 , pp. 1754-1762
    • Borg, H.1    Gottsater, A.2    Fernlund, P.3    Sundkvist, G.4
  • 29
    • 0036271280 scopus 로고    scopus 로고
    • Autoantibody profile and epitope mapping in latent autoimmune diabetes in adults
    • Falorni A, Calcinaro F. Autoantibody profile and epitope mapping in latent autoimmune diabetes in adults. Ann N Y Acad Sci 2002;958:99-106.
    • (2002) Ann N Y Acad Sci , vol.958 , pp. 99-106
    • Falorni, A.1    Calcinaro, F.2
  • 30
    • 0034457410 scopus 로고    scopus 로고
    • Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus
    • Falorni A, Gambelunghe G, Forini F, Kassi G, Cosentino A, Candeloro P, et al. Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus. J Clin Endocrinol Metab 2000;85:309-16.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 309-316
    • Falorni, A.1    Gambelunghe, G.2    Forini, F.3    Kassi, G.4    Cosentino, A.5    Candeloro, P.6
  • 31
    • 0031768145 scopus 로고    scopus 로고
    • A monoclonal antibody-based characterization of autoantibodies against glutamic acid decarboxylase in adults with latent autoimmune diabetes
    • Ziegler B, Strebelow M, Rjasanowski I, Schlosser M, Ziegler M. A monoclonal antibody-based characterization of autoantibodies against glutamic acid decarboxylase in adults with latent autoimmune diabetes. Autoimmunity 1998;28:61-8.
    • (1998) Autoimmunity , vol.28 , pp. 61-68
    • Ziegler, B.1    Strebelow, M.2    Rjasanowski, I.3    Schlosser, M.4    Ziegler, M.5
  • 33
    • 0034496772 scopus 로고    scopus 로고
    • HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD
    • Fukui M, Nakamura N, Nakano K, Kajiyama S, Matsuo S, Obayashi H, et al. HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD. Endocrine J 2000;47:753-61.
    • (2000) Endocrine J , vol.47 , pp. 753-761
    • Fukui, M.1    Nakamura, N.2    Nakano, K.3    Kajiyama, S.4    Matsuo, S.5    Obayashi, H.6
  • 35
    • 0343191485 scopus 로고    scopus 로고
    • High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry
    • Decochez K, Tits J, Coolens JL, Van Gaal L, Krzentowski G, Winnock F, et al. High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry. Diabetes Care 2000;23:838-44.
    • (2000) Diabetes Care , vol.23 , pp. 838-844
    • Decochez, K.1    Tits, J.2    Coolens, J.L.3    Van Gaal, L.4    Krzentowski, G.5    Winnock, F.6
  • 37
  • 38
    • 0029921391 scopus 로고    scopus 로고
    • Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDM
    • Kobayashi T, Nakanishi K, Murase T, Kosaka K. Small doses of subcutaneous insulin as a strategy for preventing slowly progressive beta-cell failure in islet cell antibody-positive patients with clinical features of NIDDM. Diabetes 1996;45:622-6.
    • (1996) Diabetes , vol.45 , pp. 622-626
    • Kobayashi, T.1    Nakanishi, K.2    Murase, T.3    Kosaka, K.4
  • 39
    • 12244279058 scopus 로고    scopus 로고
    • Slowly progressing type 1 diabetes: Persistence of islet cell autoantibodies is related to glibenclamide treatment
    • Cabrera-Rode E, Perich P, Diaz-Horta O, Tiberti C, Molina G, Arranz C, et al. Slowly progressing type 1 diabetes: persistence of islet cell autoantibodies is related to glibenclamide treatment. Autoimmunity 2002;35:469-74.
    • (2002) Autoimmunity , vol.35 , pp. 469-474
    • Cabrera-Rode, E.1    Perich, P.2    Diaz-Horta, O.3    Tiberti, C.4    Molina, G.5    Arranz, C.6
  • 40
    • 0036255461 scopus 로고    scopus 로고
    • Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: Implications for human type 1 diabetes
    • Beales PE, Pozzilli P. Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes. Diab Metab Res Rev 2002;18:114-7.
    • (2002) Diab Metab Res Rev , vol.18 , pp. 114-117
    • Beales, P.E.1    Pozzilli, P.2
  • 41
    • 16344390566 scopus 로고    scopus 로고
    • Rosiglitazone combined with insulin preserves islet beta cell function in adult-onset latent autoimmune diabetes (LADA)
    • Zhou Z, Li X, Huang G, Peng J, Yang L, Yan X, et al. Rosiglitazone combined with insulin preserves islet beta cell function in adult-onset latent autoimmune diabetes (LADA). Diab Metab Res Rev 2005;21:203-8.
    • (2005) Diab Metab Res Rev , vol.21 , pp. 203-208
    • Zhou, Z.1    Li, X.2    Huang, G.3    Peng, J.4    Yang, L.5    Yan, X.6
  • 42
    • 0028588120 scopus 로고
    • Islet cell antibodies are associated with β-cell failure also in obese adult onset diabetic patients
    • Gottsater A, Landin-Olsson M, Lernmark A, Fernlund P, Sundkvist G. Islet cell antibodies are associated with β-cell failure also in obese adult onset diabetic patients. Acta Diabetol 1994;31:226-31.
    • (1994) Acta Diabetol , vol.31 , pp. 226-231
    • Gottsater, A.1    Landin-Olsson, M.2    Lernmark, A.3    Fernlund, P.4    Sundkvist, G.5


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