Polymorphisms in endothelial nitric oxide synthase and carotid artery atherosclerosis

Journal of Clinical Pathology

Volumn 60, Issue 4, 2007, Pages 341-344

  Napoli, Claudio ^a   Ignarro, Louis J ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ATHEROSCLEROSIS; CAROTID ARTERY; DISEASE COURSE; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; ENVIRONMENTAL FACTOR; GENETIC COUNSELING; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ATHEROSCLEROSIS; CAROTID ARTERY DISEASES; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC;

EID: 34247114628     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2006.040550     Document Type: Review

References (50)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340:115-26.
2. Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB J 2002;16:1348-60.
3. Ignarro LJ, Cirino G, Casini A, et al. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol 1999;34:879-86.
4. Napoli C, Ignarro LJ. Nitric oxide and atherosclerosis. Nitric Oxide 2001;5:88-97.
5. Ignarro LJ, Napoli C. Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis. Curr Atheroscler Rep 2004;6:281-7.
6. Bots ML, Hoes AW, Koudstaal PJ, et al. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997;96:1432-7.
7. Hodis HN, Mack WJ, LaBree L, et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 1998;128:262-9.
8. North KE, MacCluer J, Devereux R, et al. Heritability of carotid artery structure and function: the Strong Heart Family Study. Arterioscler Thromb Vasc Biol 2002;22:1698-703.
9. Bots ML, Hofman A, de Jong PTVM, et al. Common carotid intima-media thickness as an indicator of atherosclerosis at other sites of the carotid artery. The Rotterdam Study. Ann Epidemiol 1996;6:147-53.
10. Hunt KJ, Duggirala R, Goring HHH, et al. Genetic basis of variation in carotid artery plaque in the San Antonio Family Heart Study. Stroke 2002;33:2775-80.
11. Mannami T, Katsuya T, Baba S, et al. Low potentiality of angiotensin-converting enzyme gene insertion/deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita study. Stroke 2001;32:1250-6.
12. O'Leary DH, Polak JF, Wolfson SK Jr, et al. Use of sonography to evaluate carotid atherosclerosis in the elderly. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke 1991;22:1155-63.
13. Djousse L, Myers RH, Province MA, et al. Influence of apolipoprotein E, smoking, and alcohol intake on carotid atherosclerosis: national Heart, Lung, and Blood Institute Family Heart Study. Stroke 2002;33:1357-61.
14. Fenster A, Landry A, Downey DB, et al. 3D ultrasound imaging of the carotid arteries. Curr Drug Targets Cardiovasc Haematol Disord 2004;4:161-75.
15. Zureik M, Touboul PJ, Bonithon-Kopp C, et al. Differential association of common carotid intimamedia thickness and carotid atherosclerotic plaques with parental history of premature death from coronary heart disease: the EVA study. Arterioscler Thromb Vasc Biol 1999;19:366-71.
16. Manolio TA, Boerwinkle E, O'Donnell CJ, et al. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:1567-77.
17. Humphries SE, Morgan L. Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol 2004;3:227-35.
18. Markus HS, Ruigrok Y, Ali N, et al. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Stroke 1998;29:1908-11.
19. Lembo G, De Luca N, Battagli C, et al. A common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis. Stroke 2001;32:735-40.
20. Karvonen J, Kauma H, Kervinen K, et al. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. J Intern Med 2002;251:102-10.
21. Ghilardi G, Biondi ML, DeMonti M, et al. Independent risk factor for moderate to severe internal carotid artery stenosis: T786C mutation of the endothelial nitric oxide synthase gene. Clin Chem 2002;48:989-93.
22. Asakimori Y, Yorioka N, Tanaka J, et al. Effect of polymorphism of the endothelial nitric oxide synthase and apolipoprotein E genes on carotid atherosclerosis in hemodialysis patients. Am J Kidney Dis 2003;41:822-32.
23. Grati FR, Ghilardi G, Sirchia SM, et al. Loss of heterozygosity of the NOS3 dinucleotide repeat marker in atherosclerotic plaques of human carotid arteries. Atherosclerosis 2001;159:261-7.
24. Fatini C, Safi F, Gensini F, et al. Influence of eNOS gene polymorphisms on carotid atherosclerosis. Eur J Vasc Endovasc Surg 2004;27:540-4.
25. Paradossi U, Ciofini E, Clerico A, et al. Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298→Asp and T-786→C polymorphisms. Stroke 2004;35:1305-9.
26. Wolff B, Braun C, Schluter C, et al. Endothelial nitric oxide synthase Glu→Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample. Clin Sci (Lond) 2005;109:475-81.
27. Fatini C, Sofi F, Sticchi E, et al. eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm. J Vasc Surg 2005;42:415-19.
28. Antoniades C, Tousolis D, Vasiliadou C, et al. Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors. Int J Cardiol 2006;107:95-100.
29. Binkley PF, Nuziatta E, Liu-Stratton Y, et al. A polymorphism of the endothelial nitric oxide synthase promoter is associated with an increase in autonomic imbalance in patients with congestive heart failure. Am Heart J 2005;149:342-8.
30. Casas JP, Bautista LE, Humphries SE, et al. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004;109:1359-65.
31. Chang K. The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm. Coron Artery Dis 2003;14:293-9.
32. Colombo MG, Paradossi U, Andreassi MG, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem 2003;49:389-95.
33. Stangl K, Cascorbo I, Laule M, et al. High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease. Pharmacogenetics 2000;10:133-40.
34. Ogimoto A, Shigematsu Y, Nakura J, et al. Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) in patients with coexistent hypertrophic cardiomyopathy and coronary spastic angina. J Mol Med 2005;83:619-25.
35. Spence MS, McGlinchey PG, Patterson CC, et al. Endothelial nitric oxide synthase gene polymorphism and ischemic heart disease. Am Heart J 2004;148:847-51.
36. Hibi K, Ishigami T, Tamura K, et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 1998;32:521-6.
37. Hingorani AD, Liang CF, Fatibene J, et al. A common variant of the endothelial NO synthase (Glu298->Asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999;100:1515-20.
38. Shimasaki Y, Yasue H, Yoshimura M, et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 1998;31:1506-10.
39. Buttery LD, Springall DR, Chester AH, et al. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest 1996;75:77-85.
40. Niu XL, Yang X, Hoshiai K, et al. Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions. Circulation 2001;103:1115-20.
41. Kuhlencordt PJ, Chen J, Han F, et al. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 2001;103:3099-104.
42. Hayashi T, Sumi D, Juliet PA, et al. Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. Cardiovasc Res 2004;61:339-51.
43. Miyoshi T, Li Y, Shih DM, et al. Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice. Life Sci 2006;79:525-31.
44. Tsutsui M. Neuronal nitric oxide synthase as a novel anti-atherogenic factor. J Atheroscler Thromb 2004;11:41-8.
45. Loscalzo J. Proteomics in cardiovascular biology and medicine. Circulation 2003;108:380-3.
46. Yelin R, Dahary D, Sorek R, et al. Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 2003;21:379-86.
47. Napoli C, Lerman, L O, Sica, V, et al. Microarray analysis: a novel research tool for cardiovascular scientists and physicians. Heart 2003;89:597-604.
48. Johnson JM, Edwards S, Shoemaker D, et al. Dark matter in the genome: evidence of widespread transcription detected by microarray tiling experiments. Trends Genet 2005;21:93-102.
49. Manolio TA, Boerwinkle E, O'Donnell CJ, et al. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:1567-77.
50. Spoto B, Benedetto FA, Testa A, et al. Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. Am J Hypertens 2005;18:1549-55.