Blockade of IL-2 receptor suppresses HTLV-I and IFN-γ expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

Internal Medicine

Volumn 46, Issue 7, 2007, Pages 347-351

  Fukushima, Naomi ^a   Nishiura, Yoshihiro ^a   Nakamura, Tatsufumi ^a   Kohno, Shigeru ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

HAM TSP; HTLV I; IFN ; IL 2; IL 2 receptor; Th1

Indexed keywords

GAMMA INTERFERON; HUMAN T CELL LEUKEMIA VIRUS ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR ANTIBODY; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; TROPENZILINE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL COUNT; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; MALE; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; SUPERNATANT; TH1 CELL; VIRUS LOAD;

ADULT; AGED; ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; HTLV-I ANTIGENS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERFERON TYPE II; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; PROBABILITY; RECEPTORS, INTERLEUKIN-2; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 34247111417     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.6118     Document Type: Article

References (14)

1. Osame M, Matsumoto M, Usuku K, et al. Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemia-like cells. Ann Neurol 21: 117-122, 1987.
2. Iwasaki Y. Pathology of chronic myelopathy associated with HTLV-I infection. J Neurol Sci 96: 103-123, 1990.
3. Osame M. Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP). J Neurovirol 8: 359-364, 2002.
4. Poiesz BJ, Ruscetti FW, Gazdar AF, et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77: 7415-7419, 1980.
5. Inoue J, Seiki M, Taniguchi T, et al. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type I. EMBO J 5: 2883-2888, 1986.
6. Itoyama Y, Minato S, Kira J, et al. Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy. Neurology 38: 1302-1307, 1988.
7. Tendler CL, Greenberg SJ, Blattner WA, et al. Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci USA 87: 5218-5222, 1990.
8. Azimi N, Jacobson S, Leist T, Waldmann TA. Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/ tropical spastic paraparesis: implication for therapy with a monoclonal antibody directed to the IL-2/15Rβ receptor. J Immunol 163: 4064-4072, 1999.
9. Nakamura T. Immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paraparesis. Ann Med 32: 600-607, 2000.
10. Fukushima N, Nishiura Y, Nakamura T, Yamada Y, Kohno S, Eguchi K. Involvement of p38 MAPK signaling pathway in IFN-γ and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. J Neuroimmunol 159: 196-202, 2005.
11. Crawley JB, Rawlinson L, Lali FV, Page TH, Saklatvala J, Foxwell BMJ. T cell proliferation in response to interfeukin 2 and 7 requires p38MAP kinase activation. J Biol Chem 272: 15023-15027, 1997.
12. Ellery JM, Nicholls PJ. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev 13: 27-40, 2002.
13. Osame M. Review of WHO Kagoshima meeting and diagnostic guidelines for HAM/TSP In: Human Retrovirology. HTLV. Blattner WA, Ed. Raven Press, New York, 1998: 191-197.
14. Lehky TJ, Levin MC, Kubota R, et al. Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/ tropical spastic paraparesis patients treated with humanized anti-Tac. Ann Neurol 44: 942-947, 1998.