Plasma interleukin-8 as a potential predictor of mortality in adult patients with severe traumatic brain injury

Tohoku Journal of Experimental Medicine

Volumn 211, Issue 4, 2007, Pages 387-393

  Gopcevic, Aleksandar ^a   Mazul Sunko, Branka ^a   Marout, Jasminka ^a   Sekulic, Ante ^b,c   Antoljak, Natasa ^d   Siranovic, Mladen ^a   Ivanec, Zeljko ^a   Margaritoni, Marko ^e   Bekavac Beslin, Miroslav ^a   Zarkovic, Neven ^f  

^a SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^b Division of Anesthesiology   (Croatia)

^c KBC Zagreb   (Croatia)

^d Zagreb Institute of Public Health   (Croatia)

^e UNIVERSITY OF DUBROVNIK   (Croatia)

^f RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Coma; Inflammation; Interleukin 8 (IL 8); Mortality; Traumatic brain injury (TBI)

Indexed keywords

INTERLEUKIN 8;

ADULT; AGE DISTRIBUTION; APACHE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CENTRAL VENOUS CATHETER; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GLASGOW COMA SCALE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; JUGULAR VEIN; MALE; MORTALITY; PREDICTION; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; TRAUMATIC BRAIN INJURY;

ADULT; APACHE; BIOLOGICAL MARKERS; BRAIN INJURIES; FEMALE; GLASGOW COMA SCALE; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; PROGNOSIS; ROC CURVE;

EID: 34247110462     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.211.387     Document Type: Article

References (38)

1. Adrie, C., Adib-Conquy, M., Laurent, I., Monchi, M., Vinsonneau, C., Fitting, C., Fraisse, F., Dinh-Xuan, A.T., Carli, P., Spaulding, C., Dhainaut, J.F. & Cavaillon, J.M. (2002) Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-Like" syndrome. Circulation, 106, 562-568.
2. Boto, G.R., Gomez, PA., De la Cruz, J. & Lobato, R.D. (2006) Severe head injury and the risk of early death. J. Neurol. Neurosurg. Psychiatry, 77, 1054-1059.
3. Choi, C., Kutsch, O., Park, J., Zhou, T., Seol, D.W. & Benveniste, E.N. (2002) Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent interleukin-8 expression and apoptosis in human astroglioma cells. Mol. Cell. Bio., 22, 724-736.
4. Chuang, D., Power, S.E., Dunbar, P.R. & Hill, A.G. (2005) Central nervous system interleukin-8 production following neck of femur fracture. ANZ J. Surg., 75, 813-816.
5. Croitoru-Lamoury, J., Guillemin, G.J., Boussin, F.D., Mognetti, B., Gigout, L.I., Cheet, A., Vaslin, B., Le Grand, R., Brew, B.J. & Dormont, D. (2003) Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. Glia, 41, 354-370.
6. Ehrlich, L.C., Hu, S.X., Sheng, W.S., Sutton, R.L., Rockswold, G.L., Peterson, P.K. & Chao, C.C. (1998) Cytokine regulation of human microglial cell IL-8 production. J. Immunol., 160, 1944-1948.
7. Emir, M., Ozisik K., Cagli, K., Ozisik, O., Tuncer, S., Bakuy, V., Yildirim, E., Kilinc, K. & Gol, K. (2005) Beneficial effect of methylprednisolone on cardiac myocytes in a rat model of severe brain injury. Tohoku J. Exp. Med., 207, 119-124.
8. Feldman, Z., Contant, C.F., Pahwa, R., Goodman, J.C., Robertson, C.S., Narayan, R.K. & Grossman, R.G. (1993) The relationship between hormonal mediators and systemic hypermetabolism after severe head injury. Trauma, 34, 806-812.
9. Ghajar, J. (2000) Traumatic brain injury. Lancet, 356, 923-929.
10. Hoch, R.C., Scraufstatter, I.U. & Cochrane, C.G. (1996) In vivo, in vitro and molecular aspects of interleukine-8 and the interleukin-8 receptors. J. Lab. Clin. Med., 128, 134.
11. Imai, Y., Parodo, J., Kajikawa, O., de Perrot, M., Fischer, S., Edwards, V., Cutz, E., Liu, M., Keshavjee, S., Martin, T., Marshall, I., Ranieri, V.M. & Arthur, S. (2003) Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA, 9 2104-2112.
12. Kaczorowski, S.L., Schiding, J.K., Toth, C.A. & Kochanek, P.M. (1995) Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats. J. Cereb. Blood Flow Metab., 15, 860-864.
13. Kossmann, T., Stahel, P.F., Lenzlinger, P.M., Redl, H., Dubs, R.W., Trentz, O., Schlag, G. & Morganti-Kossmann, M.C. (1997) Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J. Cereb. Blood Flaw Metab., 17, 280-289.
14. Kushi, H., Saito, T., Makino, K. & Hayashi, N. (2003) IL-8 is a key mediator of neuroinflammation after traumatic brain injury. Crit. Care Med. (Suppl.), 31, 363.
15. Maier, B., Laurer, H.L., Rose, S., Buurrman, W.A. & Marzi, I. (2005) Physiological levels of pro-and anti-inflammatory mediators in cerebrospinal fluid and plasma: A normative study. J. Neurotrauma, 22, 822-835.
16. Mastroianni, C.M., Paoletti, F., Rivosecchi, R.M., Lancella, L., Ticca, F., Vullo, V. & Delia, S. (1994) Cerebrospinal fluid interleukin - 8 in children with purulent bacterial and tuberculosus meningitis. Ped. Inf. Dis. J., 13, 1008-1010.
17. Mastroianni, C.M., Lancella, L., Mengoni, F., Lichtner, M., Santopadre, P., Dagostino, C., Ticca, F. & Vullo, V (1998) Chemokine profiles in the cerebrospinal fluid (CSF) during the course of pyogenic and tuberculous meningitis. Clin. Exp. Immunol., 22, 724-736.
18. McKeating, E.G., Andrews, P.J.D., Signorini, D.F. & Mascia, L. (1997) Transcranial cytokine gradients in patients requiring intensive care after acute brain injury Br. J. Anaesth., 78, 520-523.
19. Mimasaka, S. (2002) Postmortem cytokine levels and the cause of death. Tohoku J. Exp. Med., 197, 145-150.
20. Minami, K., Yanagawa, T., Okuda, M., Suzuki, H., Tamura, A., Izumi, G. & Yoshikawa, N. (2004) Cerebrospinal fluid cytokines in Salmonella Urbana encephalopathy. Tohoku J. Exp. Med., 203, 129-132.
21. Morganti-Kossmann, M.C., Rancan, M., Otto, V.I., Stahel, P.F. & Kossmann, T. (2001) Role of cerebral inflammation after traumatic brain injury: A revisited concept. Shock, 16, 165-177.
22. Mussack, T., Biberthaler, P., Kanz, K.G., Wiedermann, E., Gippner-Steppert, C., Mutscler, W. & Jochum, M. (2002) Serum S-100 B and interleukin-8 as predictive markers for comparative neurologic outcome analysis of patients after cardiac arrest and severe traumatic brain injury. Crit. Care. Med., 30, 2669-2674.
23. Nikolic-Heitzler, V., Rabuzin, F., Tatzber, F., Vrkic, N., Bulj, N., Borovic, S., Wonisch, W., Mazul-Sunko, B. & Zarkovic, N. (2006) Persistent oxidative stress after myocardial infarction treated by percutaneous coronary intervention. Tohoku J. Exp. Med., 210, 247-255.
24. Otto, V.I., Heinzel-Pleines, U.E., Gloor, S.M., Trentz, O., Kossmann, T. & Morganti-Kossmann, M.C. (2000) sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells. J. Neurosci. Res., 60, 733-742.
25. Papathanassoglou, E.D.E., Moynihan, J.A. & Ackerman, M.H. (2001) Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? Crit. Care. Med., 28, 537-549.
26. Pratschke, J., Wilhelm, M.J., Kusaka, M., Beato, F., Milford, E.L., Hancock, W.W. & Tilney, N.L. (2000) Accelerated rejection of renal allografts from brain-dead donors. Ann. Surg., 232, 263-271.
27. Rutland-Brown, W., Langlois, J.A., Thomas, K.E. & Lily, Y.L. (2006) Incidence of traumatic brain injury in the United States, 2003. J. Head Trauma Rehab., 21, 544-548.
28. Schlag, G., Zarkovic, K., Red, H., Zarkovic, N. & Waeg, G. (1997) Brain damage secondary to hemorrhagic shock in baboons. In: Shock, Sepsis and Organ Failure, 5th Wiggers Bernard Conference, edited by G. Schlag, H. Redl & D.L. Traber Springer-Verlag, Heidelberg, pp. 3-17.
29. Smith, W.B., Gamble, J.R, Clark-Lewis, I. & Vadas, M.A. (1991) Interleukin-8 induces neutrophil transendothelial migration. Immunology, 72, 65-72.
30. Stahel, P.F., Shohami, E., Younis, F.M., Kariya, K., Otto, V.I., Lenzlinger, P.M., Grosjean, M.B., Eugster, H.P., Trentz, O., Kossmann, T. & Morganti-Kossmann, M.C. (2000) Experimental closed head injury: Analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J. Cereb. Blood Flow Metab., 20, 369-380.
31. Stoeck, K., Bodemer, M. & Zerr, I. (2006) Pro-and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease. Neuroimmunology, 172, 175-181.
32. Whalen, M.J., Carlos, T.M., Dixon, C.E., Schiding, J.K., Clark, R.S.B., Baum, E., Yan, H.Q., Marion, D.W. & Kochanek, P.M. (1999) Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: Assessment of histopathologic and functional outcome. J. Neurotrauma, 16, 299-309.
33. Whalen, M.J., Carlos, T.M., Kochanek, P.M., Wisniewski, S.R., Bell, M.J., Clark, R.S.B., DeKosky, S.T., Marion, D.W. & Adelson, P.D. (2000) Interieukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit. Care Med., 28, 929-934.
34. Wildburger, R., Zarkovic, N., Tonkovic, G., Skoric, T., Frech, S., Hartleb, M., Loncaric, I. & Zarkovic, K. (1998) Post-traumatic hormonal disturbances: Prolactin as a link between head injury and enhanced osteogenesis. J. Endrocrinol. Invest., 21, 78-86.
35. Wildburger, R., Borovic, S., Zarkovic, N. & Tatzber, F. (2000) Post-traumatic dynamic changes of the antibody titer against oxidized low density lipoproteins. Wien. Klin. Wochenschr., 112, 798-803.
36. Wildburger, R., Zarkovic, N., Leb, G., Borovic, S., Zarkovic, K. & Tatzber, F. (2001) Post-traumatic changes of insulin like growth factor type 1 and growth hormone in patients with bone fractures and traumatic brain injury. Wien. Klin. Wochenschr., 113, 119-126.
37. Yamasaki, Y., Matsuo, Y., Zagorski, J., Matsuura, N., Onodera, H., Itoyama, Y. & Kogure, K. (1997) New therapeutic possibilities of blocking cytokine - induced neutrophil chemotractant on transient ischemic brain damage in rats. Brain Res., 759, 103-111.
38. Zhang, W.D., Smith, C., Shapiro, A., Monette, R., Hutchison, J. & Stanimirovic, D. (1999) Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro. J. Neurroimmunol, 101, 148-160.