Modulating the endocrine response in sepsis: Insulin and blood glucose control

Novartis Foundation Symposium

Volumn 280, Issue , 2007, Pages 204-215

  Vanhorebeek, Ilse ^a   Langouche, Lies ^a   Van Den Berghe, Greet ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; INSULIN;

GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; METABOLISM; REVIEW; SEPSIS;

BLOOD GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; SEPSIS;

EID: 34247099707     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (37)

1. Agus MS, Javid PJ, Ryan DP, Jaksic T 2004 Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation. J Pediatr Surg 39:839-844
2. Aulak KS, Koeck T, Crabb JW, Stuehr DJ 2004 Dynamics of protein nitration in cells and mitochondria. Am J Physiol Heart Circ Physiol 286:H30-38
3. Brownlee M 2001 Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820
4. Capes SE, Hunt D, Malmberg K, Gerstein HC 2000 Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355:773-778
5. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC 2001 Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32:2426-2432
6. Ellger B, Debaveye Y, Herijgers P, Van den Berghe G 2005 Impact of maintaining normoglycemia and glycemia-independent insulin-effects in critical illness. Intensive Care Med 31[S1]: S80, Abstract
7. Finney SJ, Zekveld C, Elia A, Evans TW 2003 Glucose control and mortality in critically ill patients. JAMA 290:2041-2047
8. Garcia Frade LJ, de la CH, Alava I, Navarro JL, Creighton LJ, Gaffney PJ 1987 Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage. Thromb Res 47:533-540
9. Gore DC, Wolf SE, Sanford AP, Herndon DN, Wolfe RR 2004 Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients. Am J Physiol Endocrinol Metab 286:E529-534
10. Grey NJ, Perdrizet GA 2004 Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 10 Suppl 2:46-52
11. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G 2003 Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 88:1082-1088
12. Harris HW, Grunfeld C, Feingold KR, Rapp JH 1990 Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice. J Clin Invest 86: 696-702
13. Harris HW, Grunfeld C, Feingold KR et al 1993 Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest 91:1028-1034
14. Hill M, McCallum R 1991 Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest 88:811-816
15. Klip A, Tsakiridis T, Marette A, Ortiz PA 1994 Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. FASEB J 8:43-53
16. Krinsley JS 2003 Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 78:1471-1478
17. Krinsley JS 2004 Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 79:992-1000
18. Lang CH, Dobrescu C, Bagby GJ 1992 Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130:43-52
19. Langouche L, Vanhorebeek I, Vlasselaers D et al 2005 Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115:2277-2286
20. McCowen KC, Malhotra A, Bistrian BR 2001 Stress-induced hyperglycemia. Crit Care Clin 17:107-124
21. Mesotten D, Delhanty PJ, Vanderhoydonc F et al 2002 Regulation of insulin-like growth factor binding protein-1 during protracted critical illness. J Clin Endocrinol Metab 87:5516-5523
22. Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G 2004 Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89:219-226
23. Meszaros K, Lang CH, Bagby GJ, Spitzer JJ 1987 Contribution of different organs to increased glucose consumption after endotoxin administration. J Biol Chem 262:10965-10970
24. Patrassi GM, Vettor R, Padovan D, Girolami A 1982 Contact phase of blood coagulation in diabetes mellitus. Eur J Clin Invest 12:307-311
25. Pekala P, Marlow M, Heuvelman D, Connolly D 1990 Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. J Biol Chem 265:18051-18054
26. Rassias AJ, Marrin CA, Arruda J, Whalen PK, Beach M, Yeager MP 1999 Insulin infusion improves neutrophil function in diabetic cardiac surgery patients. Anesth Analg 88: 1011-1016
27. Rayfield EJ, Ault MJ, Keusch GT, Brothers MJ, Nechemias C, Smith H 1982 Infection and diabetes: the case for glucose control. Am J Med 72:439-450
28. Rodnick KJ, Piper RC, Slot JW, James DE 1992 Interaction of insulin and exercise on glucose transport in muscle. Diabetes Care 15:1679-1689
29. Siroen MP, van Leeuwen PA, Nijveldt RJ, Teerlink T, Wouters PJ, Van den Berghe G 2005 Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality? Crit Care Med 33:504-510
30. Thorell A, Nygren J, Ljungqvist O 1999 Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care 2:69-78
31. Van den Berghe G 2004 How does blood glucose control with insulin save lives in intensive care? J Clin Invest 114:1187-1195
32. Van den Berghe G, Wouters P, Weekers F et al 2001 Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359-1367
33. Van den Berghe G, Wouters PJ, Bouillon R et al 2003 Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 31: 359-366
34. Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ 2005 Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64:1348-1353
35. Van den Berghe G, Wilmer A, Hermans G et al 2006 Intensive insulin therapy in medical intensive care patients. N Engl J Med 354:516-518
36. Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, Wolf-Peeters C, Van den Berghe G 2005 Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365:53-59
37. Weekers F, Giulietti AP, Michalaki M et al 2003 Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology 144:5329-5338