Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation

Journal of Pediatric Surgery

Volumn 39, Issue 6, 2004, Pages 839-844

  Agus, Michael S D ^b   Javid, Patrick J ^b   Ryan, Daniel P ^b   Jaksic, Tom ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

extracorporeal membrane oxygenation; hyperinsulinemic euglycemic clamp; insulin; metabolism; neonate; nutrition; Protein; protein breakdown

Indexed keywords

ISOTOPE; LEUCINE; PROTEIN; RECOMBINANT HUMAN INSULIN; SODIUM CHLORIDE;

ARTICLE; CASE REPORT; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; EXTRACORPOREAL OXYGENATION; FEMALE; HUMAN; INFANT; INSULIN BLOOD LEVEL; MALE; NEWBORN; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

BLOOD GLUCOSE; COHORT STUDIES; CROSS-OVER STUDIES; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; GLUCOSE; HUMANS; HYPERINSULINISM; INFANT; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INFUSIONS, INTRAVENOUS; INSULIN; LEUCINE; MALE; PARENTERAL NUTRITION, TOTAL; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTEINS; TREATMENT OUTCOME;

EID: 3042574888     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2004.02.013     Document Type: Article

References (24)

1. Keshen T.H., Miller R.G., Jahoor F., et al. Stable isotopic quantitation of protein metabolism and energy expenditure in neonates on- and post-extracorporeal life support. J Pediatr Surg. 32:1997;958-963
2. Ballard F.J., Tomas F.M., Pope L.M., et al. Muscle protein degradation in premature human infants. Clin Sci. 57:1979;535-544
3. Moyer E., Cerra F., Chenier R., et al. Multiple systems organ failure: VI. Death predictors in the trauma-septic state - The most critical determinants. J Trauma. 21:1981;862-869
4. Duffy B., Pencharz P. The effects of surgery on the nitrogen metabolism of parenterally fed human neonates. Pediatr Res. 20:1996;32-35
5. Poindexter B.B., Karn C.A., Leitch C.A., et al. Amino acids do not suppress proteolysis in premature neonates. Am J Physiol. 281:2001;E472-E478
6. Tappy L., Schwarz J.-M., Schneiter P., et al. Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med. 26:1998;860-867
7. Shew S.B., Keshen T.H., Jahoor F., et al. The determinants of protein catabolism in neonates on extracorporeal membrane oxygenation. J Pediatr Surg. 34:1999;1086-1090
8. Jahoor F., Shangraw R.E., Miyoshi H., et al. Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am J Physiol. 257:1989;E323-E331
9. DeFronzo R.A., Tobin J.D., Andres R. Glucose clamp technique A method for quantifying insulin secretion and resistance. Am J Physiol. 237:1979;E213-E223
10. Sakurai Y., Aarsland A., Herndon D.N., et al. Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann Surg. 222:1995;283-297
11. Ferrando A.A., Chinkes D.L., Wolf S.E., et al. A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 229:1999;11-18
12. Fuloria M., Friedberg M.A., DuRant R.H., et al. Effect of flow rate and insulin priming on the recovery of insulin from microbore infusion tubing. Pediatrics. 102:1998;1401-1406
13. Yu Y.-M., Wagner D.A., Walesreswski J.C., et al. A kinetic study of leucine metabolism in severely burned patients. Ann Surg. 207:1988;421-429
14. Jahoor F., Burring D.G., Reeds P.J., et al. Measurement of plasma protein synthesis rate in infant pig An investigation of alternative tracer approaches. Am J Physiol. 267:1994;R221-R227
15. Waterlow J.C., Garlick P.J., Millward D.J. Protein Turnover in Mammalian Tissues and the Whole Body. 1978;225-249. Amsterdam, North-Holland
16. 13C]leucine. Am J Physiol. 238:1980;E473-E479
17. Mitton S.G., Calder A.G., Garlick P.J. Protein turnover rates in sick, premature neonates during the first few days of life. Pediatr Res. 30:1991;418-422
18. Rivera A. Jr, Bell E.F., Bier D.M. Effect of intravenous amino acids on protein metabolism of preterm infants during the first three days of life. Pediatr Res. 33:1993;106-111
19. Beaufrere B., Fournier V., Salle B., et al. Leucine kinetics in fed low-birth-weight infants Importance of splanchnic tissues. Am J Physiol. 263:1992;E214-E220
20. Fukagawa N.K., Minaker K.L., Rowe J.W., et al. Insulin-mediated reduction of whole body protein breakdown Dose response effects on leucine metabolism in postabsorptive man. J Clin Invest. 76:1985;2306-2311
21. Denne S.C., Liechty E.A., Liu Y.M., et al. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am J Physiol. 261:1991;E809-E814
22. Poindexter B.B., Karn C.A., Denne S.C. Exogenous insulin reduces proteolysis and protein synthesis in extremely low birth weight infants. J Pediatr. 132:1998;948-953
23. Tessari P., Inchiostro S., Biolo G., et al. Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. J Clin Invest. 79:1987;1062-1069
24. Farrag H.M., Nawrath L.M., Healey J.E., et al. Persistent glucose production and greater peripheral sensitivity to insulin in the neonate vs. the adult. Am J Physiol. 272:1997;E86-E93