Effects of glucose-insulin-potassium solution on cardiac cytokines and enzymes

Thoracic and Cardiovascular Surgeon

Volumn 54, Issue 8, 2006, Pages 532-536

  Celkan, Mehmet Adnan ^a,b   Kazaz, H ^a   Daglar, B ^a   Celik, A ^a   Koruk, S ^a   Kocoglu, H ^a  

^a GAZIANTEP UNIVERSITY   (Turkey)

^b Atatürk Bulvari ^*  (Turkey)

Author keywords

Coronary bypass surgery; Myocardial infarction; Myocardial protection

Indexed keywords

ADRENALIN; CREATINE KINASE; CYTOKINE; DOPAMINE; GLUCOSE; HEART ENZYME; INOTROPIC AGENT; INSULIN; POTASSIUM; TROPONIN T; CARDIOPLEGIC AGENT; CREATINE KINASE MB; GLUCOSE INSULIN POTASSIUM CARDIOPLEGIC SOLUTION; GLUCOSE-INSULIN-POTASSIUM CARDIOPLEGIC SOLUTION; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY SINUS; ENZYME ANALYSIS; FEMALE; HEART INFARCTION; HUMAN; MALE; MUSCLE CELL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; UNSTABLE ANGINA PECTORIS; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; ENZYMOLOGY; HEART; HEART MUSCLE; INTRAOPERATIVE PERIOD; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL;

ANGINA, UNSTABLE; CARDIOPLEGIC SOLUTIONS; CORONARY ARTERY BYPASS; CREATINE KINASE, MB FORM; CYTOKINES; FEMALE; GLUCOSE; HEART; HUMANS; INSULIN; INTERLEUKIN-10; INTERLEUKIN-6; INTERLEUKIN-8; INTRAOPERATIVE PERIOD; MALE; MIDDLE AGED; MYOCARDIUM; POTASSIUM;

EID: 34247095164     PISSN: 01716425     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-924478     Document Type: Article

References (21)

1. Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, De Micheli A. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol 1962; 9: 166-181
2. Diaz R, Paolasso EA, Piegas LS, Tajer CD, Moreno MG, Corvalan R, Isea JE, Romero G. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group. Circul 1998; 98: 2227-2234
3. Lazar HL, Philippides G, Fitzgerald C, Lancaster D, Shemin RJ, Apstein C. Glucose-insulin-potassium solutions enhance recovery after urgent coronary artery bypass grafting. J Thorac Cardiovasc Surg 1997; 113: 354-362
4. Svedjeholm R, Hakanson E, Vanhanen I. Rationale for metabolic support with amino acids and glucose-insulin-potassium (GIK) in cardiac surgery. Ann Thorac Surg 1995; 59 (Suppl 2): 15-22
5. Gradinac S, Coleman G, Taegtmeyer H, Sweeney M, Frazier OH. Improved cardiac function with glucose-insulin-potassium after aorto-coronary bypass grafting. Ann Thorac Surg 1989; 48: 484-489
6. Jacquet L, Noirhomme P, El Khoury G, Goenen M, Philippe M, Col J, Dion R. Cardiac troponin I as an early marker of myocardial damage after coronary bypass surgery. Eur J Cardiothorac Surg 1998; 13: 378-384
7. Wan S, LeClere JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanism involved and possible therapeutic strategies. Chest 1997; 112: 676-692
8. Jeremy RW, Ambrosio G, Pike MM, Jacobus WE, Becker LC. The functional recovery of post-ischemic myocardium requires glycolysis during early reperfusion. J Mol Cell Cardiol 1993; 25: 261-276
9. Eberli FR, Weinberg EO, Grice WN, Horowitz GL, Apstein CS. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circ Res 1991; 68: 466-481
10. Hess ML, Okabe E, Poland J, Warner M, Stewart JR, Greenfield LJ. Glucose-insulin-potassium protection during the course of hypothermic global ischemia and reperfusion: a new proposed mechanism by the scavenging of free radicals. J Cardiovasc Pharmacol 1983; 5: 35-43
11. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias. Lancet 1994; 343: 155-158
12. Wan S, LeClere JL, Vincent JL. Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation. Ann Thorac Surg 1997; 63: 269-276
13. Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K. Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels 2004; 19: 237-241
14. Hayward R, Nossuli TO, Scalia R, Lefer AM. Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion. Eur J Pharmacol 1997; 334: 157-163
15. Khoury VK, Haluska B, Prins J, Marwick TH. Effects of glucose-insulin-potassium infusion on chronic ischemic left ventricular dysfunction. Heart 2003; 89: 61-65
16. Saraste A, Pulkki K, Kallojoki M, Henriksen K, Parvinen M, Voipio-Pulkki LM. Apoptosis in human acute myocardial infarction. Circulation 1997; 95: 320-323
17. Zhang HF, Fan Q, Qian XX, Lopez BL, Christopher TA, Ma XL, Gao F. Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis 2004; 9: 777-783
18. Bruemmer-Smith S, Avidan MS, Harris B, Sudan S, Sherwood R, Desai JB, Sutherland F, Ponte J. Glucose, insulin and potassium for heart protection during cardiac surgery. Br J Anaesthesia 2002; 88: 489-495
19. Penttila HJ, Leopojarvi MVK, Kiviluoma KT, Kaukoranta PK, Hassinen IE, Peuhkurinen PJ. Myocardial preservation during coronary surgery with and without cardiopulmonary bypass. Ann Thorac Surg 2001; 71: 565-571
20. Rao V, Mississauga ON, Merante F. Insulin cardioplegia for coronary bypass surgery. Circul 1998; 98 (Suppl): 612
21. Doenst T, Bothe W, Beyersdorf F. Therapy with insulin in cardiac surgery: Controversies and possible solutions. Ann Thorac Surg 2003; 75: 721-728