The immunosuppressive effects of 10 mg/kg cyclophosphamide in Wistar rats

Environmental Toxicology and Pharmacology

Volumn 24, Issue 1, 2007, Pages 30-36

  Hou, Fen Xia ^a   Yang, Hui Fang ^a   Yu, Tao ^a   Chen, Wei ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cyclophosphamide; Immunosuppression; Immunotoxicity test; Rat

Indexed keywords

CONCANAVALIN A; CYCLOPHOSPHAMIDE; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTATION; HISTOPATHOLOGY; HYPERSENSITIVITY REACTION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; LYMPHOCYTE PROLIFERATION; MALE; NATURAL KILLER CELL; NONHUMAN; ORGAN WEIGHT; PLAQUE FORMING CELL; PRIORITY JOURNAL; RAT; SPLEEN WEIGHT; T LYMPHOCYTE; THYMUS; WEIGHT GAIN; WEIGHT REDUCTION; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

EID: 34247092960     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2007.01.004     Document Type: Article

References (36)

1. Abe K., Natsuaki M., and Kitano Y. Suppressive effect of staphylococcal enterotoxin B on murine contact hypersensitivity. J. Dermatol. Sci. 11 (1996) 28-35
2. Banner K.H., Bertin B., Moodley I., and Page C.P. Effect of isoenzyme selective phosphodiesterase inhibitors on the proliferation of murine thymus and spleen cells. Pulmonary Pharmacol. 9 (1996) 35-41
3. Barron M.G., Heintz R., and Krahn M.M. Contaminant exposure and effects in pinnipeds: implications for Steller sea lion declines in Alaska. Sci. Tot. Environ. 311 (2003) 111-133
4. Blakley B.R., Yole M.J., Brousseau P., Boermans H., and Fournier M. Effect of pentachlorophenol on immune function. Toxicology 125 (1998) 141-148
5. Bownik A. In vitro effects of staphylococcal leukocidin LukE/LukD on the proliferative ability of lymphocytes isolated from common carp (Cyprinus carpio L.). Fish Shell fish Immunol. 20 (2006) 656-659
6. Correa R., Del Río M., and De La Fuente M. Improvement of murine immune functions in vitro by thioproline. Immunopharmacology 44 (1999) 281-291
7. Courreges M.C., Benencia F., Uceda A., and Monserrat A.J. Effect of dietary choline deficiency on immunocompetence in Wistar rats. Nutr. Res. 23 (2003) 519-526
8. Descotes G., Pinard D., Gallas J.F., Penacchio E., Blot C., and Moreau C. Extension of the 4-week safety study for detecting immune system impairment appears not necessary: example of cyclosporin A in rats. Toxicology 112 (1996) 245-256
9. Doi T., Nagai H., Tsukuda R., and Suzuki T. Dose-response relationships of cytotoxicity. PFC response and histology in the spleen in rats treated with alkylating agents. Toxicology 107 (1996) 47-60
10. Institóris L., Siroki O., Ündeger U., Basaran N., and Dési I. Immunotoxicological investigations in rats dosed repeatedly with combinations of cypermethrin, As(III) and Hg(II). Toxicology 172 (2002) 59-67
11. Institóris L., Siroki O., Undeger U., Dési I., and Nagymajtenyi L. Immunotoxicological effects of repeated combined exposure by cypermethrin and the heavy metals lead and cadmium in rats. Int. J. Immunopharmacol. 21 (1999) 735-743
12. Jurkowski M., Trojniar W., Borman A., Ciepielewski Z., Siemion D., and Tokarski J. Peripheral blood natural killer cell cytotoxicity after damage to the limbic system in the rat. Brain Behav. Immun. 15 (2001) 93-113
13. Karrow N.A., Guo T.L., Delclos K.B., Newbold R.R., Weis C., Germolec D.R., White Jr. K.L., and Ann McCaya J. Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague-Dawley rats: a two-generation feeding study. Toxicology 196 (2004) 237-245
14. Kay G., Tarcic N., Poltyrev T., and Weinstock M. Prenatal stress depresses immune function in rats. Physiol. Behav. 63 (1998) 397-402
15. Kelso J.M., Bai C.L., Ahokas J.T., and Wright P.F. In vitro effects of MOCA and dapsone on rat hepatic and splenic immune cells. Immunopharmacology 35 (1997) 183-193
16. Konjević G., Jurisić V., and Spuzić I. Corrections to the original lactate dehydrogenase (LDH) release assay for the evaluation of NK cell cytotoxicity. J. Immunol. Methods 200 (1997) 199-201
17. Krzystyniak K., Tryphonas H., and Fournier M. Approaches to the evaluation of chemical-induced immunotoxicity. Environ. Health Perspect. 103 Suppl. 9 (1995) 17-22
18. Liang-Suo J., Gomez-Flores R., and Weber R.J. Immunosuppression induced by central action of morphine is not blocked by mifepristone (RU 486). Life Sci. 71 (2002) 2595-2602
19. Lin B.F., Wu Y.J., Chiang B.L., Liu J.F., and Huang C.J. Effects of dietary oxidized frying oil on immune responses of spleen cells in rats. Nutr. Res. 17 (1997) 729-740
20. Luster M.I., Portier C., Pait D.G., White K.L., Gennings C., Munson A.E., and Rosenthal G.J. Risk assessment in toxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 18 (1992) 200-210
21. Muruganandan S., Lal J., and Gupta P.K. Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages. Toxicology 215 (2005) 57-68
22. Neigh G.N., Bilbo S.D., Hotchkiss A.K., and Nelson R.J. Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. Brain Behav. Immun. 18 (2004) 425-433
23. OPPTS (The Office of Prevention, Pesticides and Toxic Substances, United States Environmental Protection Agency), 1996. Biochemicals Test Guidelines OPPTS 880.3550 Immunotoxicity. The U.S. Government Printing Office, Washington DC.
24. Siwicki A.K., Pozet F., Morand M., Volatier C., and Terech-Majewska E. Effects of iridovirus-like agent on the cell-mediated immunity in sheatfish (Silurus glanis)-an in vitro study. Virus Res. 63 (1999) 115-119
25. Smith H.W., Winstead C.J., Stank K.K., Halstead B.W., and Wierda D. A predictive F344 rat immunotoxicology model: cellular parameters combined with humoral response to NP-CγG and KLH. Toxicology 194 (2003) 129-145
26. Swamy S.M.K., and Tan B.K.H. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J. Ethnopharmacol. 70 (2000) 1-7
27. Teunis M.A.T., Heijnen C.J., Cools A.R., and Kavelaars A. Reduced splenic natural killer cell activity in rats with a hyperreactive dopaminergic system. Psychoneuroendocrinology 29 (2004) 1058-1064
28. Tryphonas H., Bondy G., Hodgen M., Coady L., Parenteau M., Armstrong C., Hayward S., and Liston V. Effects of cis-nonachlor, trans-nonachlor and chlordane on the immune system of Sprague-Dawley rats following a 28-day oral (gavage) treatment. Food Chem. Toxicol. 41 (2003) 107-118
29. Tuchscherer M., Kanitz E., Otten W., and Tuchscherer A. Effects of prenatal stress on cellular and humoral immune responses in neonatal pigs. Vet. Immunol. Immunopathol. 86 (2002) 195-203
30. Van Loveren H., Ross P.S., Osterhaus A.D., and Vos J.G. Contaminant-induced immunosuppression and mass mortalities among harbor seals. Toxicol. Lett. 112/113 (2000) 319-324
31. Wang X.S., Zheng Y., Zuo J.P., and Fang J.N. Structural features of an immunoactive acidic arabinogalactan from Centella asiatica. Carbohyd. Polym. 59 (2005) 281-288
32. Won S.J., Huang H.F., and Lin M.T. Heatstroke induces a reduction of natural killer cell activity in rats. J. Therm. Biol. 24 (1999) 447-453
33. Wrona D., Jurkowski M.K., and Tokarski J. Blood and spleen natural killer cell cytotoxicity after exposure to open field stress in rats: the effect of spontaneous locomotor activity. J. Neuroimmunol. 150 (2004) 88-97
34. Wrona D., and Trojniar W. Chronic electrical stimulation of the lateral hypothalamus increases natural killer cell cytotoxicity in rats. J. Neuroimmunol. 141 (2003) 20-29
35. Wrona D., and Trojniar W. Suppression of natural killer cell cytotoxicity following chronic electrical stimulation of the ventromedial hypothalamic nucleus in rats. J. Neuroimmunol. 163 (2005) 40-52
36. Zhou R., Zhang F., He P.L., Zhou W.L., Wu Q.L., Xu J.Y., Zhou Y., Tang W., Li X.Y., Yang Y.F., Li Y.C., and Zuo J.P. (5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. Int. Immunopharmacol. 5 (2005) 1895-1903