메뉴 건너뛰기




Volumn 194, Issue 1-2, 2003, Pages 129-145

A predictive F344 rat immunotoxicology model: Cellular parameters combined with humoral response to NP-CγG and KLH

Author keywords

Azathioprine; Cyclophosphamide; Cyclosporin A; Immunotoxicity; Nitrophenyl; Rat

Indexed keywords

AZATHIOPRINE; BENZENE DERIVATIVE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; HAPTEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT; KEYHOLE LIMPET HEMOCYANIN; NITROPHENYL CHICKEN GAMMA GLOBULIN; UNCLASSIFIED DRUG;

EID: 0242712274     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2003.07.002     Document Type: Article
Times cited : (25)

References (45)
  • 2
    • 0002019676 scopus 로고    scopus 로고
    • Immunogenicity and antigen structure
    • William, E.P. (Ed.). Lippincott-Raven, Philadelphia, PA (Chapter 19)
    • Berzofsky, J.A., Berkower, I.J., 1999. Immunogenicity and antigen structure. In: William, E.P. (Ed.), Fundamental Immunology, fourth ed. Lippincott-Raven, Philadelphia, PA (Chapter 19).
    • (1999) Fundamental Immunology, Fourth Ed.
    • Berzofsky, J.A.1    Berkower, I.J.2
  • 3
    • 0025924915 scopus 로고
    • Effects of CI-949, a novel antiallergy agent, on immune function of male Fischer 344 rats
    • Bleavins, M.R., Iglesia, F.A., Munson, A.E., et al., 1991. Effects of CI-949, a novel antiallergy agent, on immune function of male Fischer 344 rats. J. Pharmacol. Exp. Ther. 257, 316-322.
    • (1991) J. Pharmacol. Exp. Ther. , vol.257 , pp. 316-322
    • Bleavins, M.R.1    Iglesia, F.A.2    Munson, A.E.3
  • 5
    • 0031923204 scopus 로고    scopus 로고
    • Comparison of flow cytometric and manual bone marrow differentials in Wistar rats
    • Criswell K.A., Bleavins M.R., Zielinski D., Zandee J.C. Comparison of flow cytometric and manual bone marrow differentials in Wistar rats. Cytometry. 32:1998;9-17.
    • (1998) Cytometry , vol.32 , pp. 9-17
    • Criswell, K.A.1    Bleavins, M.R.2    Zielinski, D.3    Zandee, J.C.4
  • 6
    • 0029077606 scopus 로고
    • Investigation of a screening battery for immuntoxicicity of pharmaceuticals within a 28-day oral toxicity study using azathioprine and cyclosporin A as model compounds
    • De Waal E.J., Timmerman H.H., Dortant P.M., Kranjc M.A.M., Van Loveren H. Investigation of a screening battery for immuntoxicicity of pharmaceuticals within a 28-day oral toxicity study using azathioprine and cyclosporin A as model compounds. Regul. Toxicol. Pharmacol. 21:1995;327-338.
    • (1995) Regul. Toxicol. Pharmacol. , vol.21 , pp. 327-338
    • De Waal, E.J.1    Timmerman, H.H.2    Dortant, P.M.3    Kranjc, M.A.M.4    Van Loveren, H.5
  • 7
    • 0030026471 scopus 로고    scopus 로고
    • Dose-response relationship of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents
    • Doi T., Nagai H., Tsakuda R., Suzuki T. Dose-response relationship of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents. Toxicology. 107:1996;47-60.
    • (1996) Toxicology , vol.107 , pp. 47-60
    • Doi, T.1    Nagai, H.2    Tsakuda, R.3    Suzuki, T.4
  • 8
    • 0000080398 scopus 로고
    • New tables for multiple comparisons with a control
    • Dunnett C.W. New tables for multiple comparisons with a control. Biometrics. 20:1964;482-491.
    • (1964) Biometrics , vol.20 , pp. 482-491
    • Dunnett, C.W.1
  • 9
    • 0030029996 scopus 로고    scopus 로고
    • Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats
    • Fan F., Wierda D., Rozman K.K. Effects of 2,3,7,8-tetrachlorodibenzo-p- dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. Toxicology. 106(1-3):1996;221-228.
    • (1996) Toxicology , vol.106 , Issue.1-3 , pp. 221-228
    • Fan, F.1    Wierda, D.2    Rozman, K.K.3
  • 11
    • 0035869598 scopus 로고    scopus 로고
    • Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response
    • Fleshner M., Deak T., Nguyen K.T., Watkins L.R., Maier S. Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. J. Immunol. 166:2001;3813-3819.
    • (2001) J. Immunol. , vol.166 , pp. 3813-3819
    • Fleshner, M.1    Deak, T.2    Nguyen, K.T.3    Watkins, L.R.4    Maier, S.5
  • 12
    • 0029936931 scopus 로고    scopus 로고
    • Measurements of natural killer NK activity and NK-cell quantification
    • Friberg D.D., Bryant J.L., Whiteside T.L. Measurements of natural killer NK activity and NK-cell quantification. Methods. 9:1996;316-326.
    • (1996) Methods , vol.9 , pp. 316-326
    • Friberg, D.D.1    Bryant, J.L.2    Whiteside, T.L.3
  • 13
    • 0021271884 scopus 로고
    • An enzyme-linked immunosorbent assay for measuring anti-sheep erythrocyte antibodies
    • Heyman B., Holmquist G., Borwell P., Heyman U. An enzyme-linked immunosorbent assay for measuring anti-sheep erythrocyte antibodies. J. Immunol. Methods. 68:1984;193-204.
    • (1984) J. Immunol. Methods , vol.68 , pp. 193-204
    • Heyman, B.1    Holmquist, G.2    Borwell, P.3    Heyman, U.4
  • 14
    • 0032489063 scopus 로고    scopus 로고
    • Report of validation study of assessment of direct immunotoxicity in the rat
    • ICICIS, 1998. Report of validation study of assessment of direct immunotoxicity in the rat. Toxicology 125, 183-201.
    • (1998) Toxicology , vol.125 , pp. 183-201
  • 15
    • 0037022723 scopus 로고    scopus 로고
    • Immunotoxicological investigations in rats dosed repeatedly with combinations of cypermethrin, As(III), and Hg(II)
    • Institóris L., Siroki O., Ündeger Ü., Basaran N., Dési I. Immunotoxicological investigations in rats dosed repeatedly with combinations of cypermethrin, As(III), and Hg(II). Toxicology. 172:2002;59-67.
    • (2002) Toxicology , vol.172 , pp. 59-67
    • Institóris, L.1    Siroki, O.2    Ündeger, Ü.3    Basaran, N.4    Dési, I.5
  • 16
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • Jacob J., Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:1992;679-687.
    • (1992) J. Exp. Med. , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 17
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architechture and dynamics of responding cell populations
    • Jacob J., Kassir R., Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architechture and dynamics of responding cell populations. J. Exp. Med. 173:1991;1165-1175.
    • (1991) J. Exp. Med. , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 18
    • 0242661750 scopus 로고
    • Enumeration of antigen-specific antibody-forming cells by the enzyme-linked immunospot (ELISPOT) assay
    • Burleson, G.R., Dean, J.H., Munson, A.E. (Eds.). Wiley-Liss, New York, Chapter 8
    • Kawabata, T.T., 1995. Enumeration of antigen-specific antibody-forming cells by the enzyme-linked immunospot (ELISPOT) assay. In: Burleson, G.R., Dean, J.H., Munson, A.E. (Eds.), Methods in Immunology, vol. 1. Wiley-Liss, New York, Chapter 8, pp. 125-135.
    • (1995) Methods in Immunology , vol.1 , pp. 125-135
    • Kawabata, T.T.1
  • 19
    • 0020692003 scopus 로고
    • Evaluation of ELISA for detecting in vivo chemical immunomodulation
    • Koller L.D., Exon J.H., Moore S.A. Evaluation of ELISA for detecting in vivo chemical immunomodulation. J. Toxicol. Environ. Health. 11:1983;15-22.
    • (1983) J. Toxicol. Environ. Health , vol.11 , pp. 15-22
    • Koller, L.D.1    Exon, J.H.2    Moore, S.A.3
  • 20
    • 0028011272 scopus 로고
    • Cell surface marker analysis of splenic lymphocyte populations of the CD rat for use in immunotoxicological studies
    • Ladics G.S., Loveless S.E. Cell surface marker analysis of splenic lymphocyte populations of the CD rat for use in immunotoxicological studies. Toxicol. Methods. 4(2):1994;77-91.
    • (1994) Toxicol. Methods , vol.4 , Issue.2 , pp. 77-91
    • Ladics, G.S.1    Loveless, S.E.2
  • 21
    • 0031713562 scopus 로고    scopus 로고
    • Phase two of an interlaboratory evaluation of the quantification of rat splenic lymphocyte subtypes using immunofluorescent staining and flow cytometry
    • Ladics G.S., Smith C., Loveless S.E., Green J.W. Phase two of an interlaboratory evaluation of the quantification of rat splenic lymphocyte subtypes using immunofluorescent staining and flow cytometry. Toxicol. Methods. 8:1998;87-104.
    • (1998) Toxicol. Methods , vol.8 , pp. 87-104
    • Ladics, G.S.1    Smith, C.2    Loveless, S.E.3    Green, J.W.4
  • 22
    • 0028817503 scopus 로고
    • Immunotoxicological investigation using pharmaceutical drugs. In vitro evaluation of immune effects using rodent or human immune cells
    • Lebrec H., Roger R., Blot C., Burleson G.R., Bohuon C., Pallardy M. Immunotoxicological investigation using pharmaceutical drugs. In vitro evaluation of immune effects using rodent or human immune cells. Toxicology. 96:1995;147-156.
    • (1995) Toxicology , vol.96 , pp. 147-156
    • Lebrec, H.1    Roger, R.2    Blot, C.3    Burleson, G.R.4    Bohuon, C.5    Pallardy, M.6
  • 23
    • 0003139708 scopus 로고
    • Robust tests for equality of variances
    • Olkin, I., Ghurye, S.G., Hoeffding, W., Madow, W.G., Mann, H.B. (Eds.). Stanford University Press, Stanford, CA
    • Levene, H., 1960. Robust tests for equality of variances. In: Olkin, I., Ghurye, S.G., Hoeffding, W., Madow, W.G., Mann, H.B. (Eds.), Contributions to Probability and Statistics. Stanford University Press, Stanford, CA, pp. 278-292.
    • (1960) Contributions to Probability and Statistics , pp. 278-292
    • Levene, H.1
  • 24
    • 0027935971 scopus 로고
    • CARE-LASS (calcein-release assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity
    • Lichtenfels R., Biddison W.E., Schultz H., Vogt A.B., Martin R. CARE-LASS (calcein-release assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity. J. Immunol. Methods. 172:1994;227-239.
    • (1994) J. Immunol. Methods , vol.172 , pp. 227-239
    • Lichtenfels, R.1    Biddison, W.E.2    Schultz, H.3    Vogt, A.B.4    Martin, R.5
  • 26
    • 0024271495 scopus 로고
    • The T-cell independent antigen, NP-Ficoll, primes for a high affinity IgM anti-NP response
    • Maizels N., Lan J.C., Blier P.R., Bothwell A. The T-cell independent antigen, NP-Ficoll, primes for a high affinity IgM anti-NP response. Mol. Immunol. 25(12):1988;1277-1282.
    • (1988) Mol. Immunol. , vol.25 , Issue.12 , pp. 1277-1282
    • Maizels, N.1    Lan, J.C.2    Blier, P.R.3    Bothwell, A.4
  • 27
    • 0024469770 scopus 로고
    • Solid phase enzyme-linked immunosorbent assay (ELISA) for anti-sheep erythrocyte antibody in mouse serum
    • Mori H., Sakamoto O., Xu Q., Daikoku M., Koda A. Solid phase enzyme-linked immunosorbent assay (ELISA) for anti-sheep erythrocyte antibody in mouse serum. Int. J. Immunopharm. 11(6):1989;597-606.
    • (1989) Int. J. Immunopharm. , vol.11 , Issue.6 , pp. 597-606
    • Mori, H.1    Sakamoto, O.2    Xu, Q.3    Daikoku, M.4    Koda, A.5
  • 28
    • 0030998130 scopus 로고    scopus 로고
    • Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats
    • Morris D.L., Komocsar W.J. Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats. J. Pharmacol. Toxicol. Methods. 37:1997;37-46.
    • (1997) J. Pharmacol. Toxicol. Methods , vol.37 , pp. 37-46
    • Morris, D.L.1    Komocsar, W.J.2
  • 29
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources, Commission on Life Sciences. National Academy Press, Washington, DC
    • National Research Council, 1996. Guide for the care and use of laboratory animals. Institute of Laboratory Animal Resources, Commission on Life Sciences. National Academy Press, Washington, DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 30
    • 0037024139 scopus 로고    scopus 로고
    • Blood and spleen lymphocytes as targets for immunotoxic effects in the rat - A comparison
    • Nygaard U.C., Lovik M. Blood and spleen lymphocytes as targets for immunotoxic effects in the rat - a comparison. Toxicology. 174:2002;153-161.
    • (2002) Toxicology , vol.174 , pp. 153-161
    • Nygaard, U.C.1    Lovik, M.2
  • 31
    • 0033151529 scopus 로고    scopus 로고
    • Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with medicinal plants Echinacea angustifolia and Hydrastis canadensis
    • Rehman J., Dillow J., Carter S.M., Chou J., Le B., Maisel A.S. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol. Lett. 68:1999;391-395.
    • (1999) Immunol. Lett. , vol.68 , pp. 391-395
    • Rehman, J.1    Dillow, J.2    Carter, S.M.3    Chou, J.4    Le, B.5    Maisel, A.S.6
  • 32
    • 0014601371 scopus 로고
    • Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen
    • Rittenberg M.B., Pratt K.L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc. Soc. Exp. Biol. Med. 132:1969;575-581.
    • (1969) Proc. Soc. Exp. Biol. Med. , vol.132 , pp. 575-581
    • Rittenberg, M.B.1    Pratt, K.L.2
  • 33
    • 0026556554 scopus 로고
    • Dead cell discrimination in 7-amino-actinomicin D in combination with dual color immunofluorescence in single laser flow cytometry
    • Schmid I., Krall W.J., Uittenbogaart C.H., Braun J., Giorgi J.V. Dead cell discrimination in 7-amino-actinomicin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry. 13(2):1992;204-208.
    • (1992) Cytometry , vol.13 , Issue.2 , pp. 204-208
    • Schmid, I.1    Krall, W.J.2    Uittenbogaart, C.H.3    Braun, J.4    Giorgi, J.V.5
  • 34
    • 0021711371 scopus 로고
    • Adjuvant effect of bacterial LPS and/or alum precipitation in responses to polysaccharide and protein antigens
    • Seppala I.J.T., Makela O. Adjuvant effect of bacterial LPS and/or alum precipitation in responses to polysaccharide and protein antigens. Immunology. 53:1984;827-836.
    • (1984) Immunology , vol.53 , pp. 827-836
    • Seppala, I.J.T.1    Makela, O.2
  • 35
    • 0000898845 scopus 로고
    • An analysis of variance test for normality (complete samples)
    • Shapiro S.S., Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika. 52(3-4):1965;591-611.
    • (1965) Biometrika , vol.52 , Issue.3-4 , pp. 591-611
    • Shapiro, S.S.1    Wilk, M.B.2
  • 37
    • 0028136799 scopus 로고
    • Species and strain comparison of immunosuppression by 2-methoxyethanol and 2-methoxyacetic acid
    • Smialowicz R.J., Riddle M.M., Williams W.C. Species and strain comparison of immunosuppression by 2-methoxyethanol and 2-methoxyacetic acid. Int. J. Immunopharmacol. 16(8):1994;695-702.
    • (1994) Int. J. Immunopharmacol. , vol.16 , Issue.8 , pp. 695-702
    • Smialowicz, R.J.1    Riddle, M.M.2    Williams, W.C.3
  • 38
    • 0032536872 scopus 로고    scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
    • Takahashi Y., Dutta P.R., Cerasoli D.M., Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 187(6):1998;885-895.
    • (1998) J. Exp. Med. , vol.187 , Issue.6 , pp. 885-895
    • Takahashi, Y.1    Dutta, P.R.2    Cerasoli, D.M.3    Kelsoe, G.4
  • 39
    • 77957176679 scopus 로고
    • Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide
    • Temple L., Kawabata T.T., Munson A.E., White K.L. Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamide. Fundam. Appl. Toxicol. 21:1993;412-419.
    • (1993) Fundam. Appl. Toxicol. , vol.21 , pp. 412-419
    • Temple, L.1    Kawabata, T.T.2    Munson, A.E.3    White, K.L.4
  • 41
    • 0005384482 scopus 로고
    • Evaluation of toxicity to the immune system
    • Thomas, H., Hess, R., Waechter, F. (Eds.). Taylor & Francis, London
    • Vohr, H.W., 1995. Evaluation of toxicity to the immune system. In: Thomas, H., Hess, R., Waechter, F. (Eds.), Toxicology of Industrial Compounds. Taylor & Francis, London, pp. 201-210.
    • (1995) Toxicology of Industrial Compounds , pp. 201-210
    • Vohr, H.W.1
  • 42
    • 0018805899 scopus 로고
    • Quantification of total IgM and IgG and specific IgM and IgG to a thymus-dependent (LPS) and a thymus-independent (tetanus toxoid) antigen in the rat by enzyme-linked immunosorbent assay (ELISA)
    • Vos J.G., Buys J., Beekof P., Hagenaars A.M. Quantification of total IgM and IgG and specific IgM and IgG to a thymus-dependent (LPS) and a thymus-independent (tetanus toxoid) antigen in the rat by enzyme-linked immunosorbent assay (ELISA). Ann. N. Y. Acad. Sci. 320:1979;518-534.
    • (1979) Ann. N. Y. Acad. Sci. , vol.320 , pp. 518-534
    • Vos, J.G.1    Buys, J.2    Beekof, P.3    Hagenaars, A.M.4
  • 44
    • 0027005012 scopus 로고
    • Validation: State of the art United States National Toxicology Program & Fischer 344 rat cyclosporin a study
    • White K.L. Validation: state of the art United States National Toxicology Program & Fischer 344 rat cyclosporin a study. J. Toxicol. Clin. Exp. 12(6-7):1992;429-447.
    • (1992) J. Toxicol. Clin. Exp. , vol.12 , Issue.6-7 , pp. 429-447
    • White, K.L.1
  • 45
    • 0032748331 scopus 로고    scopus 로고
    • Assessment of the functional integrity of the humoral immune response: The plaque-forming assay and the enzyme-linked immunosorbent assay
    • Wilson S.D., Munson A.E., Meade B.J. Assessment of the functional integrity of the humoral immune response: the plaque-forming assay and the enzyme-linked immunosorbent assay. Methods. 19(1):1999;3-7.
    • (1999) Methods , vol.19 , Issue.1 , pp. 3-7
    • Wilson, S.D.1    Munson, A.E.2    Meade, B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.