Sublingual immunotherapy: From safety to mechanism of action

European Annals of Allergy and Clinical Immunology

Volumn 39, Issue 3, 2007, Pages 101-103

  Marcucci, F ^a   Sensi, L ^a   Allocca, G ^a   Chiarello, F ^a   Palleri, P ^a   Ugolini, E ^a   Di Rienzo, A ^a   Castellani, S ^a   Incorvaia, C ^b   Di Cara, G ^a   Puccinelli, P ^c   Frati, F ^a,c  

^a UNIVERSITY OF PERUGIA   (Italy)

^b ICP Hospital   (Italy)

^c Medical and Scientific Department   (Italy)

Author keywords

Oral mucosa; Safety; Sublingual immunotherapy; Tolerance

Indexed keywords

ALLERGEN; BET V1 ALLERGEN; PAR J 1 ALLERGEN; PHL P1 ALLERGEN; UNCLASSIFIED DRUG;

CLINICAL EFFECTIVENESS; DOSE RESPONSE; DRUG ABSORPTION; DRUG MECHANISM; DRUG SAFETY; DRUG WITHDRAWAL; HUMAN; IMMUNOTHERAPY; RESPIRATORY TRACT ALLERGY; SHORT SURVEY; T LYMPHOCYTE ACTIVATION; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, SUBLINGUAL; ALLERGENS; DESENSITIZATION, IMMUNOLOGIC; HUMANS; MOUTH MUCOSA;

EID: 34147187854     PISSN: 03979148     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (24)

1. Bousquet J., Lockey R., Malling H.-J. (eds) - WHO Position Paper. Allergen immunotherapy: therapeutical vaccines for allergic diseases. Allergy 1998;53(suppl. 54).
2. Scadding G.-K., Brostoff J. - Low dose sublingual therapy in patients with allergic rhinitis due to house dust mite. Clin Allergy 1986;16:483-91.
3. Canonica G.-W., Passalacqua G. - Noninjection routes for immunotherapy. J Allergy Clin Immunol 2003;111:437-48.
4. Wilson D.-R., Torres-Lima M., Durham S. - Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005;60 :4-12.
5. André C., Vatrinet C., Galvain S. et al. - Safety of sublingual-swallow immunotherapy in children and adults. Int Arch Allergy Immunol 2000;121:229-234.
6. Gidaro G., Marcucci F., Sensi L. et al. - The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy 2005;35:565-71.
7. Malling H.-J. - Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results. Curr Opin Allergy Clin Immunol. 2004;4:539-42.
8. Marcucci F., Sensi L., Di Cara G. et al. - Dose dependence of immunological response to sublingual immunotherapy. Allergy 2005;60:952-56.
9. Litwin A., Flanagan M., Entis G. et al. - Oral immunotherapy with short ragweed extract in a novel encapsuled preparation: a double-blind study. J Allergy Clin Immunol 1997;100:30-8.
10. van Loon L.-A., Krieg S.-R., Davidson C.-L. et al. - Quantification and distribution of lymphocyte subsets and Langerhans cells in normal human oral mucosa and skin. J Oral Pathol Med 1989;18:197-201.
11. Bagnasco M., Mariani G., Passalacqua G. et al. - Absorption and distribution kinetics of the major Parietaria allergen administered by noninjectable routes in healthy human beings. J Allergy Clin Immunol 1997;100:121-29.
12. Bagnasco M., Passalacqua G., Villa G. et al. - Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers. Clin Exp Allergy 2001;31:54-60.
13. Passalacqua G., Altrinetti V., Mariani G. et al. - Pharmacokinetics of radiolabeled Pa j 1 administered intranasally to allergic and healthy sybjects. Clin Exp Allergy 2005;35:880-83.
14. Banchereau J., Briere F., Caux C. et al. - Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:787-811.
15. Bowen T., Greenbaum J., Charbonneau Y. et al. - Canadian trial of sublingual swallow immunotherapy for ragweed rhinoconjunctivitis. Ann Allergy Asthma Immunol 2004;93:425-430.
16. Bousquet J. - Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms. Allergy 2005;60:1-3.
17. Di Rienzo V., Marcucci F., Puccinelli P. et al. - Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 2003;33:206-10.
18. Groux H., Fournier N., Cottrez F. - Role of dendritic cells in the generation of regulatory T cells. Semin Immunol 2004;16:99-106.
19. Samson J.-N. - Regulation of antigen-specific regulatory T-cell induction via nasal and oral mucosa. Crit Rev Immunol 2004;24:157-77.
20. Battaglia M., Gianfrani C., Gregori S. et al. - IL-10 producing T regulatory type 1 cells and oral tolerance. Am N Y Acad Sci 2004;1029:142-53.
21. Ciprandi G., Fenoglio D., Cirillo I. et al. - Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report. Ann Allergy Asthma Immunol 2005;95:38-44.
22. Marcucci F., Sensi L., Frati F. et al. - Sublingual tryptase and ECP in children treated with grass-pollen sublingual immunotherapy (SLIT): safety and immunological implications. Allergy 2001;56:1091-95.
23. Marcucci F., Sensi L., Di Cara G. et al. - Sublingual reactivity to rBet v 1 and Phl p 1 in patients with oral allergy sindrome. Int J Immunopathol Pharmacol 2006;19:141-8.
24. Pajno G.-B., Vita D., Caminiti L. et al. - Children's compliance with allergen immunotherapy according to administration routes. J Allergy Clin Immunol 2005;116:1380-81.