Physicochemical profile of nimesulide. Exploring the interplay of lipophilicity, solubility and ionization

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 1, 2007, Pages 57-62

  Dellis, Demetris ^a   Giaginis, Costas ^a   Tsantili Kakoulidou, Anna ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Ionization; Lipophilicity; Mobile phase additive; Nimesulide; Reversed phase HPLC; Solubility

Indexed keywords

NIMESULIDE; OCTANOL;

ARTICLE; DRUG SOLUBILITY; IONIZATION; LIPOPHILICITY; PH MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

1-OCTANOL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUFFERS; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; LIPIDS; METHANOL; MOLECULAR STRUCTURE; SOLUBILITY; SULFONAMIDES; WATER;

EID: 34147185774     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.01.035     Document Type: Article

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