Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: Synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3- fluorocyclopropylidene]methyl}-adenines and guanines

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 3, 2007, Pages 231-243

  Zhou, Shaoman ^a   Zemlicka, Jiri ^a,d   Kern, Earl R ^b   Drach, John C ^c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d KARMANOS CANCER INSTITUTE   (United States)

Author keywords

3 Fluoromethylenecyclopropanes; Antivirals; Cyclopropavir; Nucleoside analogues

Indexed keywords

2 AMINO 6 CHLORO 9 [[2,2 (BIS(BENZYLOXYMETHYL) 3 FLUOROCYCLOPROPYLIDENE]METHYL]PURINE; 2 AMINO 6 CHLORO 9 [[2,2 BIS(HYDROXYMETHYL) 3 FLUOROCYCLOPROPYLIDENE]METHYL]PURINE; 2,2 BIS(BENZYLOXYMETHYL) 1 BROMO 1 BROMOMETHYL 3 FLUOROCYCLOPROPANE; 2,2 BIS(BENZYLOXYMETHYL) 3 BROMO 1 TERT BUTYLDIMETHYLSILYLOXYMETHYL 3 FLUOROCYCLOPROPANE; 2,2 BIS(BENZYLOXYMETHYL) 3 FLUORO 1 (2 NITROPHENYLSELENENYLMETHYL)CYCLOPROPANE; 2,2 BIS(BENZYLOXYMETHYL) 3 FLUORO 1 (HYDROXYMETHYL)CYCLOPROPANE; 2,2 BIS(BENZYLOXYMETHYL) 3 FLUORO 1 METHYLENECYCLOPROPANE; 9 [[2,2 BIS(BENZYLOXYMETHYL) 3 FLUOROCYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2,2 BIS(HYDROXYMETHYL) 3 FLUOROCYCLOPROPYLIDENE]METHYL]ADENINE; 9 [[2,2 BIS(HYDROXYMETHYL) 3 FLUOROCYCLOPROPYLIDENE]METHYL]GUANINE; ADENINE; ADENINE DERIVATIVE; ANTIVIRUS AGENT; CARBENE; CYCLOPROPANE DERIVATIVE; CYCLOPROPAVIR; FLUOROMETHANE; GUANINE DERIVATIVE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTIVIRAL ACTIVITY; ARTICLE; DECHLORINATION; DEPROTECTION REACTION; DESILYLATION; DRUG SYNTHESIS; ELIMINATION REACTION; HUMAN CYTOMEGALOVIRUS; HYDROLYSIS; ISOMER; NONHUMAN; OXIDATION; REDUCTION; VARICELLA ZOSTER VIRUS;

ADENINE; ANTIVIRAL AGENTS; BROMINE; CHEMISTRY, PHARMACEUTICAL; CYCLOPROPANES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG DESIGN; GUANINE; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; NUCLEIC ACIDS; NUCLEOSIDES; ULTRAVIOLET RAYS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 3;

EID: 34147184260     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701257210     Document Type: Article

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