Prospects for prediction: Ethics analysis of neuroimaging in Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 1097, Issue , 2007, Pages 278-295

  Illes, J ^a   Rosen, A ^b,c   Greicius, M ^b   Racine, E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aging; Alzheimer's disease; Neuroethics; Neuroimaging; Prediction

Indexed keywords

AGING; ALZHEIMER DISEASE; CLINICAL PRACTICE; CLINICAL PROTOCOL; COGNITIVE DEFECT; COMORBIDITY; CONFERENCE PAPER; COST EFFECTIVENESS ANALYSIS; CULTURAL FACTOR; DEMENTIA; ECONOMIC EVALUATION; ETHICS; ETHNICITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEALTH CARE ACCESS; HEALTH INSURANCE; HUMAN; MASS SCREENING; MEDICAL DECISION MAKING; MEDICAL EDUCATION; MEDICAL RESEARCH; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT COUNSELING; POSITRON EMISSION TOMOGRAPHY; PROFESSIONAL COMPETENCE; RISK FACTOR; SOCIAL ASPECT; STIGMA; AGED; DIAGNOSTIC IMAGING; PATHOLOGY; PREDICTION AND FORECASTING; REPRODUCIBILITY; RESEARCH ETHICS; REVIEW; RISK ASSESSMENT;

BIOLOGICAL MARKER;

AGED; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; COGNITION DISORDERS; DIAGNOSTIC IMAGING; ETHICS, RESEARCH; HUMANS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT;

EID: 34147179015     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1379.030     Document Type: Conference Paper

References (30)

1. MCKHANN, G. et al. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
2. EVANS, D.A. et al. 1989. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA 262: 2551-2556.
3. HY, L.X. & D.M. KELLER. 2000. Prevalence of AD among whites: a summary by levels of severity. Neurology 55: 198-204.
4. STRITTMATTER, W.J. et al. 1993. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 1977-1981.
5. MCCONNELL, L.M. et al. 1999. Genetic testing and Alzheimer disease: Recommendations of the Stanford Program in Genetics, Ethics and Society. Genet. Test. 3: 3-13.
6. KNOPMAN, D.S. et al. 2001. Practice parameter: diagnosis of dementia (and evidence-based review) - Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56.
7. ALBERT, M. 2005. The use of MRI and PET for clinical diagnosis of dementia and investigation of cognitive impairment. Working Report: Neuroimaging Workgroup of the Alzheimer's Association.
8. MUELLER, S.G. et al. 2005. The Alzheimer's disease neuroimaging initiative. Neuroimag. Clin. N. Am. 15: 869-877.
9. ROSEN, A.C. et al. 2002. Ethical, and practical issues in applying functional imaging to the clinical management of Alzheimer's disease. Brain Cog. 50: 498-519.
10. MENTIS, M.J. et al. 1998. Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation. Am. J. Psychiatry 155: 785-794.
11. MIELKE, R. et al. 1995. Dysfunction of visual cortex contributes to disturbed processing of visual information in Alzheimer's disease. Int. J. Neurosci. 82: 1-9.
12. THULBORN, K.R., C. MARTIN & J.T. VOYVODIC. 2000. Functional MR imaging using a visually guided saccade paradigm for comparing activation patterns in patients with probable Alzheimer's disease and in cognitively able elderly volunteers. Am. J. Neuroradiol. 21: 524-531.
13. SMITH, C. et al. 2002. Women at risk for AD show increased parietal activation during a fluency task. Neurology 58: 1197-1202.
14. BURGGREN, A.C. & S.Y. BOOKHEIMER. 2002. Structural and functional neuroimaging in Alzheimer's disease: an update. Curr. Top Med. Chem. 2: 385-393.
15. HENDRIE, H.C. 1998. Epidemiology of dementia and Alzheimer's disease. Am. J. Geriatr. Psychiatry 6: S3-S18.
16. ORGOGOZO, J.M. et al. 2003. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 61: 46-54.
17. ILLES, J. et al. 2004. Advertising, patient decision-making, and self-referral to CT and MR imaging. Arch. Int. Med. 164: 2406-2408.
18. MCMAHON, P.M. et al. 2000. Cost-effectiveness of functional imaging tests in the diagnosis of Alzheimer disease. Radiology 217: 58-68.
19. SMALL, G.W. & F. LEITER. 1998. Neuroimaging for diagnosis of dementia. J. Clin. Psychiatry 59(Suppl 11): 4-7.
20. SWETS, J.A. & R.M. PICKETT. 1982. Evaluation of Diagnostic Systems: Methods from Signal Detection Theory. Academic Press. New York.
21. KRAEMER, H.C. 1992. Evaluating MedicalTests: Objective and Quantitative Guidelines. Sage. Newbury Park, CA.
22. MACHULDA, M.M. et al. 2003. Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology 61: 500-506.
23. JACK, C.R., JR. et al. 2003. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology 60: 253-260.
24. KATZMAN, G.L., A.P. DAGHER, N.J. PATRONAS et al. 1999. Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA 281: 36-39.
25. ILLES, J. et al. 2004. Ethical consideration of incidental findings on adult MRI in research. Neurology 62: 888-890.
26. ILLES, J. et al. 2006. Incidental findings in brain imaging research. Science 311: 783-784.
27. STOCKING, C.B. et al. 2006. Speaking of research advance directives: planning for future research participation. Neurology 66: 1361-1366.
28. BACKLAR, P. 1998. Advance directives for subjects of research who have fluctuating cognitive impairments due to psychotic disorders (such as schizophrenia). Comm. Ment. Health J. 34: 229-240.
29. BERGHMANS, R.L. 1998. Advance directives for non-therapeutic dementia research: some ethical and policy considerations. J. Med. Ethics 24: 32-37.
30. MAZZIOTTA, J.C. 2000. Window on the brain. Arch. Neurol. 57: 1413-1421.