Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation

American Journal of Psychiatry

Volumn 155, Issue 6, 1998, Pages 785-794

  Mentis, Marc J ^a,b   Alexander, Gene E ^a   Krasuski, Jack ^a   Pietrini, Pietro ^a   Furey, Maura L ^a   Schapiro, Mark B ^a   Rapoport, Stanley I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; INFORMATION PROCESSING; NEUROPATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; VISUAL STIMULATION;

EID: 0031745846     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.6.785     Document Type: Article

References (54)

1. Terry RD, Peck A, DeTeresa R, Schechter MD, Horoupian DS: Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 1981; 10:184-192
2. Lewis DA, Campbell MJ, Terry RD, Morrison JH: Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J Neurosci 1987; 7:1799-1808
3. Morrison JH, Hof PR, Campbell MJ, DeLima AD, Voigt T, Bouras C, Cox K, Young WG: Cellular pathology in Alzheimer's disease: implications for corticocortical disconnection and differential vulnerability, in Imaging, Cerebral Topography and Alzheimer's Disease. Edited by Rapoport SI, Petit H, Leys D, Christen Y, Berlin, Springer-Verlag, 1990, pp 19-40
4. Yates CM, Simpson J, Gordon A, Maloney AFJ, Allison Y, Ritchie IM, Urquhart A: Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res 1983; 280:119-126
5. Chandrasekaran K, Giordano T, Brady DR, Stoll J, Martin LJ, Rapoport SI: Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease. Brain Res Mol Brain Res 1994; 24:336-340
6. Greenamyre JT, Penney JB, Damato CJ, Young AB: Dementia of the Alzheimer's type: changes in hippocampal L-[3H] glutamate binding. J Neurochem 1987; 48:543-551
7. DeKosky ST, Scheff SW, Markesbery WR: Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer's disease and aging. Neurology 1985; 35:1425-1431
8. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR; Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982; 215:1237-1239
9. Whitehouse PJ: Neurotransmitter receptor alterations in Alzheimer disease: a review. Alzheimer Dis Assoc Disord 1987; 1:9-18
10. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R: Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30:572-580
11. DeKosky ST, Scheff SW: Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990; 27:457-464
12. Frackowiak RSJ, Pozzilli C, Legg NJ, Du Boulay GH, Marshall J, Lenzi GL, Jones T: Regional cerebral oxygen supply and utilization in dementia: a clinical and physiological study with oxygen-15 and positron tomography. Brain 1981; 104:753-778
13. 18F-2-Deoxy-2-fluoro-D-glucose as a tracer in the positron emission tomographic study of senile dementia. Am J Psychiatry 1982; 139:352-353
14. de Leon MJ, Ferris SH, George AE, Reisberg B, Christman DR, Kricheff II, Wolf AP: Computed tomography and positron transaxial tomography evaluations of normal aging and Alzheimer's disease. J Cereb Blood Flow Metab 1983; 3:391-394
15. Benson DF, Kuhl DE, Hawkins RA, Phelps ME, Cummings JL, Tsai SY: The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia. Arch Neurol 1983; 40:711-714
16. Friedland RP, Budinger TF, Ganz E, Yano Y, Mathis CA, Koss B, Ober BA, Huesman RH, Derenzo SE: Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose. J Comput Assist Tomogr 1983; 7:590-598
17. Chase TN, Foster NL, Fedio P, Brooks R, Mansi L, Di Chiro G: Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography. Ann Neurol Suppl 1984; 15:S170-S174
18. Chase TN: Cortical glucose utilization patterns in primary degenerative dementia of the anterior and posterior types. Arch Gerontol Geriatr 1987; 6:289-297
19. Duara R, Grady C, Haxby J, Sundaram M, Cutler NR, Heston L, Moore A, Schlageter N, Larson S, Rapoport SI: Positron emission tomography in Alzheimer's disease. Neurology 1986; 36:879-887
20. Mentis MJ, Horwitz B, Grady CL, Alexander GE, VanMeter JW, Maisog JM, Pietrini P, Schapiro MB, Rapoport SI: Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET. Am J Psychiatry 1996; 153:32-40
21. Folstein MF, Holstein SE, McHugh PR: "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
22. Rapoport SI, Grady CL: Parametric in vivo brain imaging during activation to examine pathological mechanisms of functional failure in Alzheimer disease. Int J Neurosci 1993; 70:39-56
23. Pietrini P, Furey ML, Dani A, Freo U, Mentis MJ, Alexander GE, Rapoport SI, Schapiro MB: Functional response to audiovisual stimulation in Alzheimer patients: potential for therapeutic interventions. Abstracts of the Society for Neuroscience 1996; 22:1176
24. Mentis MJ, Alexander GE, Furey ML, Pietrini P, Strassburger T, Krasuski J, Dani A, Schapiro MB, Rapoport SI: Abnormal visual function from striate through frontal cortex in Alzheimer's disease (AD) during PET. Abstracts of the Society for Neuroscience 1996; 22:15
25. Mentis MJ, Alexander GE, Furey ML, Pietrini P, Levine B, Rapoport SI: Plastic compensation fails only at high activation levels in mild Alzheimer disease (abstract). Neurology 1997; 48: A339
26. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939-944
27. Mentis MJ, Alexander GE, Grady CL, Horwitz B, Krasuski J, Pietrini P, Strassburger T, Hampel H, Schapiro MB, Rapoport SI: Frequency variation of a pattern-flash visual stimulus during PET differentially activates brain from seriate through frontal cortex. NeuroImage 1997; 5:116-128
28. 15O: comparison of methods (abstract). J Cereb Blood Flow Metab 1987; 7:S578
29. Holden JE, Gatley SJ, Hichwa RD, Ip WR, Shaughnessy WJ, Nickles RJ, Polycn RE: Cerebral blood flow using PET measurements of fluoromethane kinetics. J Nucl Med 1981; 22:1084-1088
30. Mentis MJ, Alexander GE, Grady CL, Horwitz B: On analyzing and interpreting PET activation data in the presence of significant and biologically meaningful group global mean differences (abstract), in Human Brain Mapping: Second International Conference on Functional Mapping of the Human Brain. Edited by Toga AW, Frackowiak RS, Mazziotta JC. Boston, Academic Press, 1996, p S83
31. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RS: Statistical parametric maps in functional neuroimaging: a general linear approach. Human Brain Mapping 1995; 2:189-210
32. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain. New York, Thieme Medical, 1988
33. Winer BJ, Brown DR, Michels KM: Statistical Principles in Experimental Design, 3rd ed. New York, McGraw-Hill, 1991
34. Friston KJ, Worsley KJ, Frackowiak RS, Mazziotta JC, Evans AC: Assessing the significance of focal activations using their spatial extent. Human Brain Mapping 1994; 1:210-220
35. Fox PT, Raichle ME: Stimulus rate dependence of regional cerebral blood flow in human striare cortex, demonstrated by positron emission tomography. J Neurophysiol 1984; 51:1109-1120
36. Roy CS, Sherrington CS: On the regulation of the blood supply of the brain. J Physiol (Lond) 1890; 11:85-105
37. Reivich M: Blood flow metabolism couple in brain. Res Publ Assoc Res Nerv Ment Dis 1974; 53:125-140
38. Yarowsky P, Ingvar DH: Neuronal activity and energy metabolism. Fed Proc 1981; 40:2353-2362
39. Sokoloff L: Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed Proc 1981; 40:2311-2316
40. Clarke DD, Sokoloff L: Circulation and energy metabolism of the brain, in Basic Neurochemistry, vol 5. Edited by Siegel GJ, Agranoff BW, Albers RW, Molinoff PB. New York, Raven Press, 1994, pp 645-680
41. Schwanz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, Fink DJ, Gainer H: Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science 1979; 205:723-725
42. Kadekaro M, Crane AM, Sokoloff L: Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. Proc Natl Acad Sci USA 1985; 82:6010-6013
43. Kadekaro M, Vance WH, Terrell ML, Gary H Jr, Eisenberg HM, Sokoloff L: Effects of antidromic stimulation of the ventral root on glucose utilization in the ventral horn of the spinal cord in the rat. Proc Natl Acad Sci USA 1987; 84:5492-5495
44. Nudo RJ, Masterson RB: Stimulation-induced [14C]2-deoxyglucose labeling of synaptic activity in the central auditory system. J Comp Neurol 1986; 245:553-565
45. Jeuptner M, Weiller C: Review: does measurement of regional cerebral blood flow reflect synaptic activity? implications for PET and fMRI. Neurolmage 1995; 2:148-156
46. Geddes JW, Monaghan DT, Cotman CW, Lott IT, Kim RC, Chui HC: Plasticity of hippocampal circuitry in Alzheimer's disease. Science 1985'; 230:1179-1181
47. Cotman CW, Geddes JW, Kahle J: Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? in Progress in Brain Research. Edited by Storm-Mathisen J, Zimmer J, Ottersen OP. Amsterdam, Elsevier Science, 1990, pp 427-434
48. Schiller PH, Logothetis NK, Charles ER: Functions of the colour-opponent and broad-band channels of the visual system. Nature 1990; 343:68-70
49. Merigan WH: P and M pathway specialization in the macaque, in From Pigments to Perception. Edited by Valberg A, Lee BB. New York, Plenum Press, 1991, pp 117-125
50. Livingstone MS, Hubel DH: Psychophysical evidence for separate channels for the perception of form, color, movement and depth, J Neurosci 1987; 7:3416-3468
51. Van Essen DC, Gallant JL: Neural mechanisms of form and motion processing in the primate visual system. Neuron 1994; 13:1-10
52. Maunsell JHR, Nealey TA, DePriest DD: Magnocellular and parvocellular contributions to responses in the middle temporal visual area (MT) of the macaque monkey. J Neurosci 1990; 10:3323-3334
53. Ferrera VP, Nealey TA, Maunsell JH: Responses in macaque visual area V4 following inactivation of the parvocellular and magnocellular LGN pathways. J Neurosci 1994; 14:2080-2088
54. Nealey TA, Maunsell JH: Magnocellular and parvocellular contributions to the responses of neurons in macaque striate cortex. J Neurosci 1994; 14:2069-2079