Diagnosis of acute renal allograft rejection by analyzing whole blood mRNA expression of lymphocyte marker molecules

Transplantation

Volumn 83, Issue 6, 2007, Pages 791-798

  Alakulppi, Noora S ^a   Kyllönen, Lauri E ^b   Partanen, Jukka ^a   Salmela, Kaija T ^b   Laine, Jarmo T ^a  

^a FINNISH RED CROSS BLOOD SERVICE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Acute rejection; Kidney transplantation; mRNA expression; Whole blood

Indexed keywords

CD40 LIGAND; CYCLOSPORIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND; GRANULYSIN; GRANZYME B; INDUCIBLE T LYMPHOCYTE COSTIMULATOR PROTEIN; LYMPHOCYTE SURFACE MARKER; MESSENGER RNA; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PERFORIN; PROGRAMMED CELL DEATH 1 PROTEIN; PROTEIN; TACROLIMUS; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GRAFT RECIPIENT; GRAFT REJECTION; HUMAN; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; APOPTOSIS REGULATORY PROTEINS; CD40 LIGAND; FAS LIGAND PROTEIN; FEMALE; GRAFT REJECTION; GRANZYMES; HUMANS; KIDNEY TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PORE FORMING CYTOTOXIC PROTEINS; PROSPECTIVE STUDIES; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS;

EID: 34147163526     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000258726.13363.ab     Document Type: Article

References (35)

1. Joosten SA, Sijpkens YW, Van Kooten C, Paul LC. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int 2005; 68: 1.
2. Simon T, Opelz G, Wiesel M, et al. Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients. Am J Transplant 2003; 3: 1121.
3. Hartono C, Dadhania D, Suthanthiran M. Noninvasive diagnosis of acute rejection of solid organ transplants. Front Biosci 2004; 9: 145.
4. Kirk AD, Bollinger RR, Finn OJ. Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection. Hum Immunol 1995; 43: 113.
5. Vasconcellos LM, Schachter AD, Zheng XX, et al. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation 1998; 66: 562.
6. Sarwal MM, Jani A, Chang S, et al. Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation. Hum Immunol 2001; 62: 21.
7. Li B, Hartono C, Ding R, et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 2001; 344: 947.
8. Sabek O, Dorak MT, Kotb M, et al. Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation. Transplantation 2002; 74: 701.
9. Muthukumar T, Ding R, Dadhania D, et al. Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts. Transplantation 2003; 75: 1565.
10. Dadhania D, Muthukumar T, Ding R, et al. Molecular signatures of urinary cells distinguish acute rejection of renal allografts from urinary tract infection. Transplantation 2003; 75: 1752.
11. Simon T, Opelz G, Wiesel M, et al. Serial peripheral blood interleukin-18 and perforin gene expression measurements for prediction of acute kidney graft rejection. Transplantation 2004; 77: 1589.
12. Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353: 2342.
13. Dugre FJ, Gaudreau S, Belles-Isles M, et al. Cytokine and cytotoxic molecule gene expression determined in peripheral blood mononuclear cells in the diagnosis of acute renal rejection. Transplantation 2000; 70: 1074.
14. Zhou PJ, Tang XD, Wang XH, Xu D. Immune activation gene expression in CD28 costimulated lymphocytes and its application as a diagnostic tool in kidney transplantation. Transplant Proc 2000; 32: 1774.
15. Satterwhite T, Chua MS, Hsieh SC, et al. Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppression. Pediatr Transplant 2003; 7: 53.
16. Kotsch K, Mashreghi MF, Bold G, et al. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation 2004; 77: 1866.
17. Shin GT, Kim SJ, Lee TS, et al. Gene expression of perforin by peripheral blood lymphocytes as a marker of acute rejection. Nephron Clin Pract 2005; 100: c63.
18. Gibbs PJ, Tan LC, Sadek SA, Howell WM. Quantitative detection of changes in cytokine gene expression in peripheral blood mononuclear cells correlates with and precedes acute rejection in renal transplant recipients. Transpl Immunol 2005; 14: 99.
19. Graziotto R, Del Prete D, Rigotti P, et al. Perforin, Granzyme B, and Fas Ligand for Molecular Diagnosis of Acute Renal-Allograft Rejection: Analyses on Serial Biopsies Suggest Methodological Issues. Transplantation 2006; 81: 1125.
20. Tatapudi RR, Muthukumar T, Dadhania D, et al. Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004; 65: 2390.
21. Shoker A, George D, Yang H, Baltzan M. Heightened CD40 ligand gene expression in peripheral CD4+ T cells from patients with kidney allograft rejection. Transplantation 2000; 70: 497.
22. Sarwal M, Chua MS, Kambham N, et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125.
23. Liang M, Cowley AW, Jr, Hessner MJ, et al. Transcriptome analysis and kidney research: toward systems biology. Kidney Int 2005; 67: 2114.
24. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
25. Dheda K, Huggett JF, Bustin SA, et al. Validation of housekeeping genes for normalizing RNA expression in real-time PCR. Biotechniques 2004; 37: 112.
26. Nemlander A, Soots A, von Willebrand E, et al. Redistribution of renal allograft-responding leukocytes during rejection. II. Kinetics and specificity. J Exp Med 1982; 156: 1087.
27. Hoffmann SC, Hale DA, Kleiner DE, et al. Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 2005; 5: 573.
28. Hoffmann SC, Pearl JP, Blair PJ, Kirk AD. Immune profiling: molecular monitoring in renal transplantation. Front Biosci 2003; 8: e444.
29. Zheng XX, Schachter AD, Vasconcellos L, et al. Increased CD40 ligand gene expression during human renal and murine islet allograft rejection. Transplantation 1998; 65: 1512.
30. Soulillou JP. Immune monitoring for rejection of kidney transplants. N Engl J Med 2001; 344: 1006.
31. McLean A. What goes around (in kidney transplant rejection) does not necessarily come around (in the blood). Am J Transplant 2003; 3: 1045.
32. Lachenbruch PA, Rosenberg AS, Bonvini E, et al. Biomarkers and surrogate endpoints in renal transplantation: present status and considerations for clinical trial design. Am J Transplant 2004; 4: 451.
33. Halloran PF, Reeve J, Kaplan B. Lies, damn lies, and statistics: the perils of the P value. Am J Transplant 2006; 6: 10.
34. Sarwal MM. Chipping into the human genome: novel insights for transplantation. Immunol Rev 2006; 210: 138.
35. Kramar A, Faraggi D, Fortune A, Reiser B. mROC: a computer program for combining tumour markers in predicting disease states. Comput Methods Programs Biomed 2001; 66: 199.