What goes around (in kidney transplant rejection) does not necessarily come around (in the blood)

American Journal of Transplantation

Volumn 3, Issue 9, 2003, Pages 1045-1046

  McLean, Adam ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GRANZYME B; MESSENGER RNA; PERFORIN;

BLOOD; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; POLYMERASE CHAIN REACTION; REVIEW;

ANTIGENS, CD8; BIOLOGICAL MARKERS; GRAFT REJECTION; GRANZYMES; KIDNEY TRANSPLANTATION; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0042863337     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-6143.2003.00233.x     Document Type: Review

References (8)

1. Chisholm GD, Papadimitriou M, Kulatilake AE, Shackman R. The diagnosis of rejection of renal allotransplants in man. Lancet 1969; 1: 904-906.
2. Kincaid-Smith P. Histological diagnosis of rejection of renal homografts in man. Lancet 1967; 2: 849-852.
3. Sabek O, Dorak MT, Kotb M, Gaber AO, Gaber L. Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation. Transplantation 2002; 74: 701-707.
4. Li B, Hartono C, Ding R et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med 2001; 344: 947-954.
5. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States: 1988-96. N Engl J Med 2000; 342: 605-612.
6. Callard R, George AJ, Stark J. Cytokines, chaos, and complexity. Immunity 1999; 11: 507-513.
7. Dallman MJ, Wood KJ, Morris PJ. Specific cytotoxic T cells are found in the nonrejected kidneys of blood-transfused rats. J Exp Med 1987; 165: 566-571.
8. Bose A, Inoue Y, Kokko KE, Lakkis FG. Cutting edge. perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ. J Immunol 2003; 170: 1611-1614.