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Volumn 100, Issue 4, 2007, Pages 393-399

Pulmonary arterial hypertension: Evaluation and management

Author keywords

Endothelin; Prostacyclin; Pulmonary hypertension; Pulmonary vascular disease

Indexed keywords

ADENOSINE; AMBRISENTAN; BERAPROST; BOSENTAN; DIGITALIS; DIURETIC AGENT; ILOPROST; NITRIC OXIDE; PROSTACYCLIN; SEROTONIN; SILDENAFIL; SITAXSENTAN; UNIPROST; VASOACTIVE INTESTINAL POLYPEPTIDE; WARFARIN;

EID: 34147148630     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/SMJ.0b013e31802f2ff1     Document Type: Review
Times cited : (12)

References (49)
  • 1
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension: A national prospective study
    • Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987;107:216-223.
    • (1987) Ann Intern Med , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 2
    • 0034803780 scopus 로고    scopus 로고
    • Medical therapy of pulmonary hypertension: Conventional therapies
    • Naeije R, Vachiery JL. Medical therapy of pulmonary hypertension: conventional therapies. Clin Chest Med 2001;22:517-527.
    • (2001) Clin Chest Med , vol.22 , pp. 517-527
    • Naeije, R.1    Vachiery, J.L.2
  • 3
    • 50449119090 scopus 로고
    • Primary pulmonary hypertension, I: Clinical and hemodynamic study
    • Dresdale DT Schultz M, Michtom RJ. Primary pulmonary hypertension, I: clinical and hemodynamic study. Am J Med 1951:11:686-705.
    • (1951) Am J Med , vol.11 , pp. 686-705
    • Dresdale, D.T.1    Schultz, M.2    Michtom, R.J.3
  • 4
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004;43(12 Suppl S):5S-12S.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.12 SUPPL. S
    • Simonneau, G.1    Galie, N.2    Rubin, L.J.3
  • 5
    • 0032578279 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet 1998;352:719-725.
    • (1998) Lancet , vol.352 , pp. 719-725
    • Gaine, S.P.1    Rubin, L.J.2
  • 6
    • 27744597750 scopus 로고    scopus 로고
    • Pulmonary hypertension surveillance: United States, 1980-2002
    • Hyduk A, Croft JB, Ayala C, et al. Pulmonary hypertension surveillance: United States, 1980-2002 MMWR Surveill Summ. 2005;54:1-28.
    • (2005) MMWR Surveill Summ , vol.54 , pp. 1-28
    • Hyduk, A.1    Croft, J.B.2    Ayala, C.3
  • 7
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber HW, Loscalzo J. Pulmonary arterial hypertension N Engl J Med 2004;351:1655-1665.
    • (2004) N Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 8
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder RM, Cool CD, Geraci MW, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999;159:1925-1932.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3
  • 9
    • 0021839058 scopus 로고
    • Quantitative assessment of pulmonary hypertension in patients with tricuspid regurgitation using continuous wave Doppler ultrasound
    • Berger M, Haimonwitz A, Van Tosh, A et al. Quantitative assessment of pulmonary hypertension in patients with tricuspid regurgitation using continuous wave Doppler ultrasound. J Am Coll Cardiol 1985;6:359-365.
    • (1985) J Am Coll Cardiol , vol.6 , pp. 359-365
    • Berger, M.1    Haimonwitz, A.2    Van Tosh, A.3
  • 10
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993;328:1732-1739.
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 11
    • 0035910729 scopus 로고    scopus 로고
    • Microsatellite instability of endothelial cell growth and apoptosis within plexiform lesions in primary pulmonary hypertension
    • Yeager ME, Halley GR, Golpon HA, et al. Microsatellite instability of endothelial cell growth and apoptosis within plexiform lesions in primary pulmonary hypertension Circ Res 2001;88:e2-e11.
    • (2001) Circ Res , vol.88
    • Yeager, M.E.1    Halley, G.R.2    Golpon, H.A.3
  • 12
    • 13444309082 scopus 로고    scopus 로고
    • Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension
    • Machado RD, James V, Southwood M, et al. Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension. Circulation 2005;111:607-613.
    • (2005) Circulation , vol.111 , pp. 607-613
    • Machado, R.D.1    James, V.2    Southwood, M.3
  • 13
    • 9444287592 scopus 로고    scopus 로고
    • Appetite-suppressant drugs and the risk of primary pulmonary hypertension
    • Abenhaim L, Moride Y, Brenot F, et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996;335:609-616.
    • (1996) N Engl J Med , vol.335 , pp. 609-616
    • Abenhaim, L.1    Moride, Y.2    Brenot, F.3
  • 14
    • 0030853476 scopus 로고    scopus 로고
    • Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine
    • Mark EJ, Patalas ED, Chang HT, et al. Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine. N Engl J Med 1997;337:602-606.
    • (1997) N Engl J Med , vol.337 , pp. 602-606
    • Mark, E.J.1    Patalas, E.D.2    Chang, H.T.3
  • 15
    • 0020564431 scopus 로고
    • An epidemic of pulmonary hypertension after toxic rapeseed oil ingestion in Spain
    • Garcia-Dorado D, Miller DD, Garcia EJ, et al. An epidemic of pulmonary hypertension after toxic rapeseed oil ingestion in Spain. J Am Coll Cardiol 1983;1:1216-1222.
    • (1983) J Am Coll Cardiol , vol.1 , pp. 1216-1222
    • Garcia-Dorado, D.1    Miller, D.D.2    Garcia, E.J.3
  • 16
    • 15444354123 scopus 로고    scopus 로고
    • HIV-associated primary pulmonary hypertension: A case control study
    • Opravil M, Pechere M, Speich R, et al. HIV-associated primary pulmonary hypertension: a case control study. Am J Respir Crit Care Med 1997;155:990-995.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 990-995
    • Opravil, M.1    Pechere, M.2    Speich, R.3
  • 17
    • 0031844681 scopus 로고    scopus 로고
    • Pulmonary vascular disorders in portal hypertension
    • Hervé P, Lebrec D, Brenot F, et al. Pulmonary vascular disorders in portal hypertension. Eur Respir J 1998;11:1153-1166.
    • (1998) Eur Respir J , vol.11 , pp. 1153-1166
    • Hervé, P.1    Lebrec, D.2    Brenot, F.3
  • 18
    • 0037364372 scopus 로고    scopus 로고
    • Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease
    • Arcasoy SM, Christie JD, Ferrari VA, et al. Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med 2003;167:735-740.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 735-740
    • Arcasoy, S.M.1    Christie, J.D.2    Ferrari, V.A.3
  • 19
    • 0018823981 scopus 로고
    • Lung biopsy specimens in the evaluation of pulmonary vascular disease
    • Wagenvoort CA. Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest 1980;77:614-625.
    • (1980) Chest , vol.77 , pp. 614-625
    • Wagenvoort, C.A.1
  • 20
    • 0035162391 scopus 로고    scopus 로고
    • Diagnosis of pulmonary arterial hypertension and pulmonary embolism with magnetic resonance angiography
    • Kruger S, Haage P, Hoffmann R, et al. Diagnosis of pulmonary arterial hypertension and pulmonary embolism with magnetic resonance angiography Chest 2001;120:1556-1561.
    • (2001) Chest , vol.120 , pp. 1556-1561
    • Kruger, S.1    Haage, P.2    Hoffmann, R.3
  • 21
    • 22544449525 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Diagnosis with fast perfusion MR imaging and high-spacial- resolution MR angiography-preliminary experience
    • Nikolaou K, Schoenberg SO, Attenberger U, et al. Pulmonary arterial hypertension: diagnosis with fast perfusion MR imaging and high-spacial- resolution MR angiography-preliminary experience. Radiology 2005;236:694-703.
    • (2005) Radiology , vol.236 , pp. 694-703
    • Nikolaou, K.1    Schoenberg, S.O.2    Attenberger, U.3
  • 22
    • 0028849117 scopus 로고
    • More on the noninvasive diagnosis of pulmonary hypertension: Doppler echocardiography revisited
    • Naeije R, Torbicki A. More on the noninvasive diagnosis of pulmonary hypertension: Doppler echocardiography revisited. Eur Respir J 1995;8:1445-1449.
    • (1995) Eur Respir J , vol.8 , pp. 1445-1449
    • Naeije, R.1    Torbicki, A.2
  • 23
    • 0034809907 scopus 로고    scopus 로고
    • The assessment of pulmonary hypertension
    • McGoon M. The assessment of pulmonary hypertension. Clin Chest Med 2001;22:493-508.
    • (2001) Clin Chest Med , vol.22 , pp. 493-508
    • McGoon, M.1
  • 24
    • 0021143486 scopus 로고
    • Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation
    • Yock PG, Popp RL. Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 1984;70:657-662.
    • (1984) Circulation , vol.70 , pp. 657-662
    • Yock, P.G.1    Popp, R.L.2
  • 25
    • 0034978260 scopus 로고    scopus 로고
    • A comparison of echocardiography and pulmonary artery catheterization for evaluation of pulmonary artery pressures in pregnant patients with suspected pulmonary hypertension
    • Penning S, Robinson KD, Major CA, et al. A comparison of echocardiography and pulmonary artery catheterization for evaluation of pulmonary artery pressures in pregnant patients with suspected pulmonary hypertension. Am J Obstet Gynecol 2001;184:1568-1570.
    • (2001) Am J Obstet Gynecol , vol.184 , pp. 1568-1570
    • Penning, S.1    Robinson, K.D.2    Major, C.A.3
  • 26
    • 0030841153 scopus 로고    scopus 로고
    • Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis
    • Denton CP, Cailes JB, Phillips GD, et al. Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis. Br J Rheum 1997;36:239-243.
    • (1997) Br J Rheum , vol.36 , pp. 239-243
    • Denton, C.P.1    Cailes, J.B.2    Phillips, G.D.3
  • 27
    • 0032783062 scopus 로고    scopus 로고
    • Echocardiographic features of primary pulmonary hypertension
    • Bossone E, Duong-Wagner TH, Paciocco G, et al. Echocardiographic features of primary pulmonary hypertension. J Am Soc Echocardiogr 1999;12:655-662.
    • (1999) J Am Soc Echocardiogr , vol.12 , pp. 655-662
    • Bossone, E.1    Duong-Wagner, T.H.2    Paciocco, G.3
  • 28
    • 0023097259 scopus 로고
    • Comparison of three Doppler ultrasound methods in the prediction of pulmonary artery pressure
    • Chan KL, Currie PJ, Seward JB, et al. Comparison of three Doppler ultrasound methods in the prediction of pulmonary artery pressure. J Am Coll Cardiol 1987;9:549-554.
    • (1987) J Am Coll Cardiol , vol.9 , pp. 549-554
    • Chan, K.L.1    Currie, P.J.2    Seward, J.B.3
  • 29
    • 0033931829 scopus 로고    scopus 로고
    • Accuracy of Doppler echocardiography in the assessment of pulmonary hypertension in liver transplant candidates
    • Kim WR, Krowka MJ, Plevak DJ, et al. Accuracy of Doppler echocardiography in the assessment of pulmonary hypertension in liver transplant candidates. Liver Transpl 2000;6:453-458.
    • (2000) Liver Transpl , vol.6 , pp. 453-458
    • Kim, W.R.1    Krowka, M.J.2    Plevak, D.J.3
  • 30
    • 8244225826 scopus 로고    scopus 로고
    • Hinderliter AL, Willis PW IV, Barst RJ, et al. Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension: primary pulmonary hypertension study group. Circulation 1997;95:1479-1486.
    • Hinderliter AL, Willis PW IV, Barst RJ, et al. Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension: primary pulmonary hypertension study group. Circulation 1997;95:1479-1486.
  • 31
    • 0034107636 scopus 로고    scopus 로고
    • Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: Comparison with cardiopulmonary testing
    • Miyamoto S, Nagaya N, Satoh T, et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary testing. Am J Respir Crit Care Med 2000;161:487-492.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 487-492
    • Miyamoto, S.1    Nagaya, N.2    Satoh, T.3
  • 32
    • 12244251412 scopus 로고    scopus 로고
    • Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension
    • McLaughlin VV, Gaine SP, Barst RJ, et al. Efficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertension. J Cardiovasc Pharmaol 2003;41:293-299.
    • (2003) J Cardiovasc Pharmaol , vol.41 , pp. 293-299
    • McLaughlin, V.V.1    Gaine, S.P.2    Barst, R.J.3
  • 33
    • 0037151645 scopus 로고    scopus 로고
    • Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival
    • Sitbon O, Humbert M, Nunes H, et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol 2002;40:780-788.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 780-788
    • Sitbon, O.1    Humbert, M.2    Nunes, H.3
  • 34
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension: The Primary Pulmonary Hypertension Study Group
    • Barst RJ, Rubin LJ, Long WA, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension: the Primary Pulmonary Hypertension Study Group. N Engl J Med 1996;334:296-302.
    • (1996) N Engl J Med , vol.334 , pp. 296-302
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3
  • 35
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analog, in patients with pulmonary arterial hypertension: A double-blind randomized, placebo-controlled trial
    • Simmonneau G, Barst RJ, Galie N, et al. Continuous subcutaneous infusion of treprostinil, a prostacyclin analog, in patients with pulmonary arterial hypertension: a double-blind randomized, placebo-controlled trial. Am J Respir Crit Care Med 2002;165:800-804.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 800-804
    • Simmonneau, G.1    Barst, R.J.2    Galie, N.3
  • 36
    • 0038037766 scopus 로고    scopus 로고
    • Beraprost therapy for pulmonary arterial hypertension
    • Barst RJ, McGoon M, McLaughlin V, et al. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol ; 2003;41:2119-2125.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2119-2125
    • Barst, R.J.1    McGoon, M.2    McLaughlin, V.3
  • 37
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iolprost for severe pulmonary hypertension
    • Olschewski H, Simmonneau G, Galie N, et al. Inhaled iolprost for severe pulmonary hypertension. N Engl J Med 2002;347:322-329.
    • (2002) N Engl J Med , vol.347 , pp. 322-329
    • Olschewski, H.1    Simmonneau, G.2    Galie, N.3
  • 38
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary artery hypertension
    • Galie N, Ghofrani HA, Torbicki A, et al. Sildenafil citrate therapy for pulmonary artery hypertension. N Engl J Med 2005;353:2148-2157.
    • (2005) N Engl J Med , vol.353 , pp. 2148-2157
    • Galie, N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 39
    • 13844280943 scopus 로고    scopus 로고
    • Survival with first-line bosentan in patients with primary pulmonary hypertension
    • McLaughlin VV, Sitbon O, Badesch DB, et al. Survival with first-line bosentan in patients with primary pulmonary hypertension. Eur Respir J 2005;25:244-249.
    • (2005) Eur Respir J , vol.25 , pp. 244-249
    • McLaughlin, V.V.1    Sitbon, O.2    Badesch, D.B.3
  • 40
    • 11144304239 scopus 로고    scopus 로고
    • STRIDE 1: Effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmarterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials
    • Langleben D, Brock T, Dixon R, et al. STRIDE 1: effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmarterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials. J Cardiovasc Pharmacol 2004;44:S80-S84.
    • (2004) J Cardiovasc Pharmacol , vol.44
    • Langleben, D.1    Brock, T.2    Dixon, R.3
  • 41
    • 34147096933 scopus 로고    scopus 로고
    • Business Wire from April 10, 2006, Gilead Sciences, Inc. ARIES-1 Trial. Available at: http://investor.myogen.com/phoenix.zhtml?c= 135160&p= irolnewsArticle&ID=781654&highlight=. Accessed March 1, 2007.
    • Business Wire from April 10, 2006, Gilead Sciences, Inc. ARIES-1 Trial. Available at: http://investor.myogen.com/phoenix.zhtml?c= 135160&p= irolnewsArticle&ID=781654&highlight=. Accessed March 1, 2007.
  • 42
    • 29144465056 scopus 로고    scopus 로고
    • Serotonin induces pulmonary artery smooth muscle cell migration
    • Day R, Agyman AS, Segel MJ, et al. Serotonin induces pulmonary artery smooth muscle cell migration. Biochem Pharmacol 2006;71:386-397.
    • (2006) Biochem Pharmacol , vol.71 , pp. 386-397
    • Day, R.1    Agyman, A.S.2    Segel, M.J.3
  • 43
    • 0035845634 scopus 로고    scopus 로고
    • Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension
    • Wilkens H, Guth A, König J, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001;104:1218-1222.
    • (2001) Circulation , vol.104 , pp. 1218-1222
    • Wilkens, H.1    Guth, A.2    König, J.3
  • 44
    • 0021193273 scopus 로고
    • Primary pulmonary hypertension: Natural history and the importance of thrombosis
    • Fuster V, Steele PM, Edwards WD, et al. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 1984;70:580-587.
    • (1984) Circulation , vol.70 , pp. 580-587
    • Fuster, V.1    Steele, P.M.2    Edwards, W.D.3
  • 45
    • 0026632785 scopus 로고
    • The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension
    • Rich S, Kaugmann E, Levy PS. The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension. N Engl J Med 1992;327:76-81.
    • (1992) N Engl J Med , vol.327 , pp. 76-81
    • Rich, S.1    Kaugmann, E.2    Levy, P.S.3
  • 46
    • 0030813510 scopus 로고    scopus 로고
    • The effect of anticoagulant therapy in primary and anorectic drug-induced pulmonary hypertension
    • Frank H, Mlczoch J, Huber K, et al. The effect of anticoagulant therapy in primary and anorectic drug-induced pulmonary hypertension. Chest 1997;112:714-721.
    • (1997) Chest , vol.112 , pp. 714-721
    • Frank, H.1    Mlczoch, J.2    Huber, K.3
  • 47
    • 1542296540 scopus 로고    scopus 로고
    • Medical management
    • Rubin L, Rich S, eds, New York, Marcel Dekker
    • Rubin LJ, Rich S. Medical management. . In: Rubin L, Rich S, eds. Primary Pulmonary Hypertension. New York, Marcel Dekker, 1997, pp 271-286.
    • (1997) Primary Pulmonary Hypertension , pp. 271-286
    • Rubin, L.J.1    Rich, S.2
  • 48
    • 0037810650 scopus 로고    scopus 로고
    • Tricuspid valvular disease in the patient with chronic pulmonary thromboembolic disease
    • Thistlethwaite PA, Jamieson SW. Tricuspid valvular disease in the patient with chronic pulmonary thromboembolic disease. Curr Opin Cardiol 2003;18:111-116.
    • (2003) Curr Opin Cardiol , vol.18 , pp. 111-116
    • Thistlethwaite, P.A.1    Jamieson, S.W.2
  • 49
    • 0036184353 scopus 로고    scopus 로고
    • Improvement of tricuspid regurgitation after pulmonary thromboendarterectomy
    • Menzel T, Kramm T, Wagner S, et al. Improvement of tricuspid regurgitation after pulmonary thromboendarterectomy. Ann Thorac Surg 2002;73:756-761.
    • (2002) Ann Thorac Surg , vol.73 , pp. 756-761
    • Menzel, T.1    Kramm, T.2    Wagner, S.3


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