Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia

Experimental Lung Research

Volumn 33, Issue 2, 2007, Pages 71-80

  Yanagihara, Katsunori ^a,c   Fukuda, Yuichi ^a   Seki, Masafumi ^a   Izumikawa, Koichi ^a   Miyazaki, Yoshitsugu ^a   Hirakata, Yoichi ^a   Tsukamoto, Kazuhiro ^b   Yamada, Yasuaki ^a   Kamhira, Shimeru ^a   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Murine model; Neutrophil elastase; Pneumonia; Sivelestat

Indexed keywords

LEUKOCYTE ELASTASE INHIBITOR; PENICILLIN G; SIVELESTAT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BLOOD CELL COUNT; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HISTOPATHOLOGY; INOCULATION; LOBAR PNEUMONIA; LUNG HEMORRHAGE; LUNG INFILTRATE; LUNG LAVAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE;

ANIMALS; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; GLYCINE; LEUKOCYTE ELASTASE; LUNG; MICE; MICE, INBRED CBA; PNEUMONIA, PNEUMOCOCCAL; SERINE PROTEINASE INHIBITORS; STREPTOCOCCUS PNEUMONIAE; SULFONAMIDES; SURVIVAL RATE;

EID: 34147136269     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140701198500     Document Type: Article

References (17)

1. Pallares R, Linares J, Vadillo M, et al: Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain. N Engl J Med. 1995;333:474-480.
2. Bergeron Y, Ouellet N, Deslauriers AM, Simard M, Olivier M, Bergeron MG: Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice. Infect Immun. 1998;66:912-922.
3. Bergeron Y, Ouellet N, Simard M, Olivier M, Bergeron MG: Immunomodulation of pneumococcal pulmonary infection with N(G)-monomethyl-L- arginine. Antimicrob Agents Chemother. 1999;43:2283-2290.
4. Havemann K, Gramse M: Physiology and pathophysiology of neutral proteinases of human granulocytes. Adv Exp Med Biol. 1984;167:1-20.
5. Kawabata K, Hagio T, Matsumoto S, et al: Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Crit Care Med. 2000;161:2013-2018.
6. Yasui S, Nagai A, Aoshiba K, Ozawa Y, Kakuta Y, Konno K: A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster. Eur Respir J. 1995;8:1293-1299.
7. Matsumoto K, Aizawa H, Inoue H, Koto H, Nakano H, Hara N: Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs. Eur Respir J. 1999;14:1088-1094.
8. Hagio T, Matsumoto S, Nakao S, Abiru T, Ohno H, Kawabata K: Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters. Eur J Pharmacol. 2004;488:173-180.
9. Otsu Y, Yanagihara K, Fukuda Y, et al: In vivo efficacy of a new quinolone, DQ-113, against Streptococcus pneumoniae in a mouse model. Antimicrob Agents Chemother. 2003;47:3699-3703.
10. Yanagihara K, Fukuda Y, Miyazaki Y, et al: Pharmacodynamics and bactericidal activity of gatifloxacin in experimental pneumonia caused by penicillin-resistant Streptococcus pneumoniae. Chemotherapy. 2004;50:107-112.
11. Fukuda Y, Yanagihara K, Ohno H, et al: In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model. Antimicrob Agents Chemother. 2006;50:121-125.
12. Yanagihara K, Seki M, Cheng PW: Lipopolysaccharide induces mucus cell metaplasia in mouse lung. Am J Respir Cell Mol Biol. 2001;24:66-73.
13. Kaneko Y, Yanagihara K, Seki M, et al: Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. Am J Physiol Lung Cell Mol Physiol. 2003;285:L847-L853.
14. Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T: ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991;177:814-820.
15. Greene C, Taggart C, Lowe G, Gallagher P, McElvaney N, O'Neill S: Local impairment of antineutrophil elastase capacity in community-acquired pneumonia. J Infect Dis. 2003;188:769-776.
16. Lee WL, Downey GP: Leukocyte elastase: Physiological functions and role in acute lung injury. Am J Respir Crit Care Med. 2001;164:896-904.
17. Akimoto A, Mori H, Namba T, et al: The effect of sivelestat sodium hydrate (ONO-5046Na) on neutrophil phylaxis function in vitro. Jpn Pharmacol Ther. 2003;31:85-91 (in Japanese).