Impaired executive performance in healthy siblings of schizophrenia patients in a population-based study

Schizophrenia Research

Volumn 92, Issue 1-3, 2007, Pages 142-150

  Kuha, Annamaria ^a,b   Tuulio Henriksson, Annamari ^a,b   Eerola, Mervi ^a,b   Perälä, Jonna ^a   Suvisaari, Jaana ^a   Partonen, Timo ^a   Lönnqvist, Jouko ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cognition; Family studies; Neuropsychology; Schizophrenia; Vulnerability

Indexed keywords

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; EFFECT SIZE; FAMILY STUDY; FEMALE; HUMAN; LEARNING; MAJOR CLINICAL STUDY; MALE; MEMORY; MOTOR PERFORMANCE; NEUROPSYCHOLOGICAL TEST; POPULATION RESEARCH; PRIORITY JOURNAL; SCHIZOPHRENIA; SIBLING; STATISTICAL ANALYSIS; VISUAL MEMORY;

ADULT; COGNITION DISORDERS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POPULATION SURVEILLANCE; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX; SIBLINGS;

EID: 34147133768     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.01.007     Document Type: Article

References (53)

1. Albus M., Hubmann W., Mohr F., Scherer J., Sobizack N., Franz U., Hecht S., Borrmann M., and Wahlheim C. Are there gender differences in neuropsychological performance in patients with first episode schizophrenia?. Schizophr. Res. 28 (1997) 39-50
2. Aleman A., Hijman R., de Haan E., and Kahn R.S. Memory impairment in schizophrenia. Am. J. Psychiatry 156 (1999) 1358-1366
3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
4. Andrewes D. Neuropsychology: From Theory to Practice (2004), Psychology Press Ltd, New York
5. Army Individual Test Battery. In Manual of Direction and Scoring (1944), Ward Department, Washington, DC
6. Aromaa A., and Koskinen S. Health and functional capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey. KTL National Public Health Institute, Finland (2004), Dpt of Health and Functional Capacity, Helsinki
7. Baddeley A. Working memory. Science 255 (1992) 556-559
8. Brebion G., Amador X., Smith M.J., and Gorman J.M. Memory impairment and schizophrenia: the role of processing speed. Schizophr. Res. 30 (1998) 31-39
9. Cannon T.D., Huttunen M.O., Lönnqvist J., Tuulio-Henriksson A., Pirkola T., Glahn D., Finkelstein J., Hietanen M., Kaprio J., and Koskenvuo M. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am. J. Hum. Genet. 67 (2000) 369-382
10. Cirillo M.A., and Seidman L.J. Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychol. Rev. 13 (2003) 43-77
11. Cohen J.E. Statistical Power Analysis for the Behavioral Sciences (1988), Erlbaum, Hilsdale, NY
12. Conklin H.M., Curtis C.E., Calkins M.E., and Iacono W.G. Working memory functioning in schizophrenia patients and their first-degree relatives: cognitive functioning shedding light on etiology. Neuropsychologia 43 (2005) 930-942
13. Delis D.C., Kramer J.H., Kaplan E., and Ober B.A. California Verbal Learning Test. Manual. Research, The Psychological Corporation (1987), Harcourt Brace & Company, San Antonio
14. Egan M.F., Goldberg T.E., Gsheidle B., Weirich M., Bigelow L., and Weinberger D.R. Relative risk of attention deficits in siblings of patients with schizophrenia. Am. J. Psychiatry 157 (2000) 1309-1316
15. Egan M.F., Goldberg T.E., Gscheide T., Weirich M., Rawlings R., Hyde T.M., Bigelow L., and Weinberger D.R. Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol. Psychiatry 50 (2001) 98-107
16. Faraone S.V., Seidman L.J., Kremen W.S., Pepple J.R., Lyons M.J., and Tsuang M.T. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J. Abnorm. Psychology 104 (1995) 286-304
17. Faraone S.V., Seidman L.J., Kremen W.S., Toomey R., Pepple J.R., and Tsuang M.T. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J. Abnorm. Psychology 108 (1999) 176-181
18. Faraone S.V., Seidman L.J., Kremen W.S., Toomey R., Pepple J.R., and Tsuang M.T. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol. Psychiatry 48 (2000) 120-126
19. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV) (1997), American Psychiatric Press, Washington, DC
20. Glahn D., Therman S., Manninen M., Huttunen M.O., Kaprio J., Lönnqvist J., and Cannon T.D. Spatial working memory as an endophenotype for schizophrenia. Biol. Psychiatry 53 (2003) 624-626
21. Glahn D., Almasy L., Blangero J., Burk G.M., Estrada J., Peralta J.M., Meyenberg N., Castro M.P., Barrett J.A., Nicolini H., Raventós H., and Escamilla M. Adjudicating neurocognitive endophenotypes for schizophrenia. Am. J. Med. Genet. Part B (Neuropsychiatric Genetics) 144B (2006) 242-249
22. Gold J.M., Rehkemper G., Binks S.W.R., Carpenter C.J., Flaming K., Goldberg T.E., and Weinberger D.R. Learning and forgetting in schizophrenia. Am. J. Psychiatry 109 (2000) 534-538
23. Goldberg T.E., Egan M.F., Gscheidle T., Coppola R., Weickert T., Kolachana B.S., Goldman D., and Weinberger D.R. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val58Met genotype and schizophrenia. Arch. Gen. Psychiatry 60 (2003) 889-896
24. Heinrichs R.W., and Zakzanis K.K. Neurocognitive deficits in schizophrenia: a quantitative review of the evidence. Neuropsychology 12 (1998) 426-445
25. Heydebrand G. Cognitive deficits in the families of patients of schizophrenia. Curr. Opin. Psychiatry 19 (2006) 277-281
26. Hoff A.L., Svetina C., Maurizio A.M., Crow T.J., Spokes K., and DeLisi L.E. Familial cognitive deficits in schizophrenia. Am. J. Med. Genet., B Neuropsychiatr. Genet. 133B (2005) 43-49
27. Hoff A.L., Svetina C., Shields G., Stewart J., and DeLisi L.E. Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia. Schizophr. Res. 78 (2005) 27-34
28. Hoti F., Tuulio-Henriksson A., Haukka J., Partonen T., Holmström L., and Lönnqvist J. Family-based clusters of cognitive test performance in familial schizophrenia. BMC Psychiatry 4 (2004) 20
29. Koskinen S., Kestilä L., Martelin T., and Aromaa A. The health of young adults. Baseline Results of the Health 2000 Study on the Health of 18-29-Years-Olds and the Factors Associated with It (2005), Publications of the National Public Health Institute, Helsinki
30. Krabbendam L., Arts B., Van Os J., and Aleman A. Cognitive functioning in patients with schizophrenia and bipolar disorder: a quantitative review. Schizophr. Res. 80 (2005) 137-149
31. Laurent A., Biloa-Tang M., Bougerol T., Duly D., Anchisi A.-M., Bosson J.-L., Pellat J., d' Amato T., and Dalery J. Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophr. Res. 46 (2000) 269-283
32. Lezak M.D., Howieson D.B., and Loring D.W. Neuropsychological Assessment (2004), Oxford University Press, New York
33. Mahurin R.K., Velligan D.I., Hazleton B., Davis J.M., Eckert S., and Miller A.L. Trail Making Test errors and executive function in schizophrenia and depression. Clin. Neuropsychol. 20 (2006) 271-288
34. McGuffin P., Farmer A.E., and Harvey I. A polydiagnostic application of operational criteria in psychotic illness: development and reliability of the OPCRIT system. Arch. Gen. Psychiatry 48 (1991) 764-770
35. McIntosh A.M., Harrison L.K., Forrester K., Lawrie S.M., and Johnstone E.C. Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. Br. J. Psychiatry 186 (2005) 378-385
36. Mirsky A.F., Lochhead S.J., Jones B.P., Kugelmass S., Walsh D., and Kendler K.S. On familial factors in the attentional deficit in schizophrenia: a review and report of the two new subject samples. J. Psychiatr. Res. 26 (1992) 383-403
37. Park S., Holzman P.S., and Goldman-Rakic P.S. Spatial working memory deficits in the relatives of schizophrenia patients. Arch. Gen. Psychiatry 52 (1995) 821-828
38. Perälä J., Suvisaari J., Saarni S.I., Kuoppasalmi K., Isometsä E., Pirkola S., Partonen T., Tuulio-Henriksson A., Hintikka J., Kieseppä T., Härkänen T., Koskinen S., and Lönnqvist J. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch. Gen. Psychiatry 64 (2007) 19-28
39. Shedlack K., Lee G., Sakuma M., Xie S.-H., Kushner M., Pepple J., Finer D.L., Hoff A.L., and DeLisi L.E. Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr. Res. 25 (1997) 43-52
40. Sitskoorn M.M., Aleman A., Ebisch S.J., Appels M.C., and Kahn R.S. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr. Res. 71 (2004) 285-295
41. Snitz B.E., MacDonald III A., and Carter C.S. Cognitive defects in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr. Bull. 32 (2006) 179-194
42. StataCorp. Stata Statistical Software: Release 8.0 (2003), Stata Corporation, TX
43. Stuss D.T., Bisschop S.M., Alexander M.P., Levine B., Katz D., and Izukawa D. The Trail Making Test: a study in focal lesion patients. Psychol. Assess. 13 (2001) 230-239
44. Szoke A., Schurhoff F., Mathieu F., Meary A., Ionescu S., and Leboyer M. Tests of executive functions in first-degree relatives of schizophrenia patients: a meta-analysis. Psychol. Med. 35 (2005) 771-782
45. Trandafir A., Méary A., Schürhoff F., Leboyer M., and Szöke A. Memory tests in first-degree adult relatives of schizophrenic patients: a meta-analysis. Schizophr. Res. 81 (2006) 217-226
46. Tsuang M.T., Stone W.S., and Faraone S.V. Genes, environment and schizophrenia. Br. J. Psychiatry Suppl. 40 (2001) s18-s24
47. Tuulio-Henriksson A., Haukka J., Partonen T., Varilo T., Paunio T., Ekelund J., Cannon T.D., Meyer J.M., and Lönnqvist J. Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia. Am. J. Med. Genet. 114 (2002) 483-490
48. Tuulio-Henriksson A., Arajärvi R., Partonen T., Haukka J., Varilo T., Schreck M., Cannon T., and Lönnqvist J. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol. Psychiatry 54 (2003) 623-628
49. Wechsler D. Wechsler Adult Intelligence Scale - Revised (WAIS-R) (1981), The Psychological Corporation, Cleveland
50. Wechsler D. Wechsler Memory Scale - Revised (WMS-R) (1987), The Psychological Corporation, San Antonio
51. Whyte M.-C., Brett C., Harrison L.K., Byrne M., Miller P., Lawrie S.M., and Johnstone E.C. Neuropsychological performance over time in people at high risk of developing schizophrenia and controls. Biol. Psychiatry 59 (2005) 730-739
52. Whyte M.-C., McIntosh A.M., Johnstone E.C., and Lawrie S.M. Declarative memory in unaffected adult relatives of patients with schizophrenia: a systematic review and meta-analysis. Schizophr. Res. 78 (2005) 13-26
53. Zeger S.L.L., and Liang K.Y. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42 (1986) 121-130