Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family

Journal of Biological Chemistry

Volumn 282, Issue 5, 2007, Pages 3188-3195

  Zhou, Mingyan ^a   Xia, Li ^a   Engel, Karen ^a,b   Wang, Joanne ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MERCK KGAA   (Germany)

^c H272J Health Sciences Bldg ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE MUTANTS; AMPHIPATHIC PATTERN; CATION TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER (ENT); PLASMA MEMBRANE MONOAMINE TRANSPORTER;

BIOCHEMISTRY; MOLECULAR MECHANICS; MUTAGENESIS; ORGANIC COMPOUNDS; SUBSTRATES;

CELL MEMBRANES;

1 METHYL 4 PHENYLPYRIDINIUM; ALANINE; CATION; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; GLUTAMINE; MONOAMINE TRANSPORTER; MUTANT PROTEIN; NUCLEOSIDE; ORGANIC CATION TRANSPORTER; THREONINE; UNCLASSIFIED DRUG; URIDINE; NERVE PROTEIN; PMAT PROTEIN, HUMAN; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL PERMEABILIZATION; CELL SURFACE; CHIMERA; CLUSTER ANALYSIS; CONTROLLED STUDY; ENZYME SPECIFICITY; HYDROPHILICITY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; SURFACE CHARGE; TARGET CELL; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOG; GENETIC TRANSFECTION; HUMAN; KIDNEY; KINETICS; MAMMAL; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATIONS; CELL LINE; DOGS; HUMANS; KIDNEY; KINETICS; MAMMALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 34047262009     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609421200     Document Type: Article

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