Cytotoxicity and DNA-damage in human lung epithelial cells exposed to respirable α-quartz

Toxicology in Vitro

Volumn 21, Issue 4, 2007, Pages 586-594

  Fanizza, Carla ^a   Ursini, Cinzia Lucia ^a   Paba, Emilia ^a   Ciervo, Aureliano ^a   Di Francesco, Arianna ^a   Maiello, Raffaele ^a   De Simone, Paolo ^a   Cavallo, Delia ^a  

^a ISPESL   (Italy)

Author keywords

Comet assay; Cytotoxicity; Direct oxidative DNA damage; Respirable quartz; SEM analysis

Indexed keywords

ALPHA QUARTZ; LACTATE DEHYDROGENASE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; BREATHING; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG TOXICITY; MICROVILLUS; OXIDATIVE STRESS; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING;

AEROSOLS; CELL LINE; DNA DAMAGE; EPITHELIAL CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LUNG; MICROSCOPY, ELECTRON, SCANNING; OXIDATIVE STRESS; PARTICLE SIZE; QUARTZ; RESPIRATORY MUCOSA;

EID: 34047255281     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.12.002     Document Type: Article

References (61)

1. American Conference of Governmental Industrial Hygienists (ACGIH). TLV and BEI Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices (2000), ACGIH, Cincinnati
2. American Conference of Governmental Industrial Hygienists (ACGIH). TLV and BEI Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices (2004), ACGIH, Cincinnati pp. 73-76
3. American Conference of Governmental Industrial Hygienists (ACGIH). TLV and BEI Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices (2006), ACGIH, Cincinnati
4. Albrecht C., Knaapen A.M., Becker A., Höhr D., Haberzettl P., van Schooten F., Borm P.J.A., and Schins R.P.F. The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-I induction in rat lung. Respiratory Res. 6 (2005) 129-144
5. Balduzzi M., Diociaiuti M., De Berardis B., Paradisi S., and Paoletti L. In vitro effects on macrophages induced by noncytotoxic doses of silica particles relevant to ambient exposure. Environ. Res. 96 (2004) 62-72
6. Blanco D., Vicent S., Elizegi E., Pino I., Fraga M.F., Esteller M., Saffiotti U., Locanda F., and Montuenga L.M. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab. Invest. 84 (2004) 999-1012
7. Borm P.J.A., and Driscoll K.E. Particles inflammation and respiratory tract carcinogenesis. Toxicol. Lett. 88 (1996) 109-113
8. Cakmak G.D., Schins R.P.F., Shi T., Fenoglio I., Fubini B., and Borm P.J.A. In vitro genotoxicity assessment of commercial quartz flours in comparison to standard DQ12 quartz. Int. J. Environ. Health 207 (2004) 105-113
9. Cavallo D., Campopiano A., Cardinali G., Casciardi S., De Simone P., Kovacs D., Perniconi B., Spagnoli G., Ursini C.L., and Fanizza C. Cytotoxic and oxidative effects induced by man-made vitreous fibers (MMVFs) on a human mesothelial cell line. Toxicology 201 (2004) 219-229
10. Chen W., Zhuang Z., Attfield M.D., Chen B.T., Gao P., Harrison J.C., Fu C., Chen J.Q., and Wallace W.E. Exposure to silica and silicosis among tin miners in China: exposure-response analyses and risk assessment. Occup. Environ. Med. 58 (2001) 1372-1377
11. Cherry N.M., Burgess G.L., Turner S., and McDonald J.C. Crystalline silica and risk of lung cancer in the potteries. Occup. Environ. Med. 55 (1998) 779-785
12. Collins A.R., Duthie S.J., and Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 14 (1993) 1733-1735
13. Daniel L.N., Mao Y., and Saffiotti U. Direct interaction between crystalline silica and DNA: a proposed model for silica carcinogenesis. Scand. J. Work Environ. Health 21 2 (1995) 22-26
14. Donaldson K., and Borm P.J.A. The quartz hazard: a variable entity. Ann. Occup. Hyg. 42 (1998) 287-294
15. Don Porto Carero A., Hoet P.H., Varschaeva L., Schoetars G., and Nemery B. Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1). Environ. Mol. Mutagen. 3 (2001) 155-163
16. Driscoll K.E., Deyo L.C., Carter J.M., Howard B.W., Hassenbein D.G., and Bertram T.A. Effects of particles exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis 18 (1997) 423-430
17. Finkelstein M.M. Silicosis surveillance in Ontario from 1979 to 1992. Scand. J. Work Environ. Health 21 (1995) 55-57
18. Fotakis G., and Timbrell J.A. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 160 2 (2006) 171-177
19. Fubini B., Giamello E., Volante M., and Bolis V. Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. Toxicol. Ind. Health 6 (1990) 571-598
20. Fubini B., Bolis V., Cavenago A., and Volante M. Physicochemical properties of crystalline silica dusts and their possible implication in various biological responses. Scand. J. Work Environ. Health 21 Suppl. 2 (1995) 9-14
21. Fubini B., Fenoglio B., Elias Z., and Poirot O. Variability of biological responses to silicas: effect of origin, crystallinity, and state of surface on generation of reactive oxygen species and morphological transformation of mammalian cells. J. Environ. Pathol. Toxicol. Oncol. 20 1 (2001) 95-108
22. Gao N., Keane J., Ong T., Ye J., Miller W.E., and Wallace W.E. Effects of phospholipids surfactant on apoptosis induction by respirable quartz and kaolin in NR8383 rat pulmonary macrophages. Toxicol. Appl. Pharmacol. 175 (2001) 217-225
23. Grant R.L., Yao C., Gabaldon D., and Acosta D. Evaluation of surfactant cytotoxicity potential by primary cultures of ocular tissues: I. Characterization of rabbit corneal epithelial cells and initial injury and delayed toxicity studies. Toxicology 76 (1992) 153-176
24. Hughes J.M., Weill H., Rando R.J., Shi R., McDonald A.D., and McDonald J.C. Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. Ann. Occup. Hyg. 45 (2001) 201-207
25. International Agency for Research on Cancer (IARC). Monograph on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Silica, Some Silicates, Coal Dust and Para-aramid Fibrils vol. 68 (1997), IARC Press, Geneva
26. Johnson N.F., Smith D.M., Sebring L.M., and Holland L.M. Silica-induced alveolar cell tumors in rats. Am. J. Ind. Med. 11 (1987) 93-107
27. Johnston C., Driscoll K.E., Finkelstein J.N., Baggs R., O'Reill M., Carter J., Gelein R., and Oberdörster G. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol. Sci. 56 (2000) 405-413
28. Kauppinen T., Toikkanen J., Pederson D., Young R., Ahrens W., Boffetta P., Hansen J., Kromhout H., Blasco J.M., Mirabelli D., de la Orden-Rivera V., Pannett B., Plato N., Savela A., Vincent R., and Kogevinas M. Occupational exposure to carcinogens in the European Union. Occup. Environ. Med 57 (2000) 10-18
29. Knaapen A.M., Albrecht C., Becker A., Höhr D., Winzer A., Haenen G.R., Borm P.J.A., and Schins R.P.F. DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation. Carcinogenesis 23 (2002) 1111-1120
30. Kim H.N., Morimoto Y., Tsuda T., Ootsuyama Y., Hirahashi M., Hirano T., Tanaka I., Lim Y., Yun I.-G., and Kasai H. Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. Carcinogenesis 22 (2001) 265-269
31. Koskela R.S., Klochkars M., Laurent H., and Holopainen M. Silica dust exposure and lung cancer. Scand. J. Work Environ. Health 20 6 (1994) 407-416
32. Kreiss K., and Zhen B. Risk of silicosis in a Colorado mining community. Am. J. Ind. Med. 30 (1996) 529-539
33. Malorni W., and Donelli G. Cell death: general features and morphological aspects. Ann. NY Acad. Sci. (1992) 218-233
34. Marnett l.J. Oxyradicals and DNA damage. Carcinogenesis 21 (2000) 361-370
35. McDonald J.C., McDonald A.D., Hughes J.M., Rando R.J., and Weill H. Mortality from lung and kidney disease in a cohort of North American industrial sand workers: an update. Ann. Occup. Hyg. 49 (2005) 367-373
36. Miller K., Handfield R.I.M., and Kagan E. The effects of different mineral dusts on the mechanism of phagocytosis: a scanning electron microscope study. Environ. Res. 15 (1978) 139-154
37. Miller K. Alterations in the surface-related phenomena of alveolar macrophages following inhalation of crocidolite asbestos and quartz dusts: an overview. Environ. Res. 20 (1979) 162-182
38. Muhle H., Kittel B., Ernst H., Mohr U., and Mermelstein R. Neoplastic lung lesions in rat after chronic exposure to crystalline silica. Scand. J. Work Environ. Health 21 (1995) 27-29
39. Nehls P., Seiler F., Rehn B., Greferath R., and Bruch J. Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure. Environ. Health Perspect. 105 (1997) 1291-1296
40. Nij E.T., and Heederik D. Risk assessment of silicosis and lung cancer among construction workers exposed to respirable quartz. Scand. J. Work Environ. Health 31 (2005) 49-56
41. Rosenman K.D., Reilly M.J., Rice C., Hertzberg V., Tseng C.Y., and Anderson H.A. Silicosis among foundry workers: Implication for the need to revise the OSHA standard. Am. J. Epidemiol. 144 9 (1996) 890-900
42. Saffiotti U., Daniel L.N., Mao Y., Shi X., Williams A.O., and Kaighn M.E. Mechanisms of carcinogenesis by crystalline silica in relation to oxygen radicals. Environ. Health Perspect. 102 10 (1994) 159-163
43. Seiler F., Rehn B., Rehn S., and Bruch J. Quartz exposure of the rat lung leads to a linear dose response in inflammation but not in oxidative DNA damage and mutagenicity. Am. J. Respir. Cell Mol. Bio. 24 (2001) 492-498
44. Seiler F., Rehn B., Rehn S., and Bruch J. Different toxic, fibrogenic and mutagenic effects of four commercial quartz flours in the rat lung. Int. J. Hyg. Environ. Health 207 (2004) 115-124
45. Sherson D., Svane O., and Lynge E. Cancer incidence among foundry workers in Denmark. Arch. Environ. Health 46 (1991) 75-81
46. Schins R.P.F., Duffin R., Höhr D., Knaapen A.M., Shi T., Weishaupt C., Stone V., Donaldson K., and Borm P.J.A. Surface modifications of quartz inhibits toxicity particle uptake, and oxidative DNA damage in human lung epithelial cells. Chem. Res. Toxicol. 15 (2002) 1166-1177
47. Schins R.P.F., Knaapen A.D., Cakmak G.D., Shi T., Weishaupt C., and Borm P.J.A. Oxidant-induced DNA damage by quartz in alveolar epithelial cells. Mutat. Res. 517 (2002) 77-86
48. Shi X., Castranova V., Halliwell V., and Vallyathan V. Reactive oxygen species and silica-induced carcinogenesis. J. Toxicol. Environ. Health B 1 (1998) 181-197
49. Soutar C.A., Robertson A., Miller B.G., Searl A., and Bignon J. Epidemiological evidence on the carcinogenity of silica: factors in scientific judgement. Ann. Occup. Hyg. 94 (2000) 3-14
50. Spiethoff A., Wesch H., Wegener K., and Klimisch H.J. The effects of Thorotrast and quartz on the induction of lung tumors in rats. Health Phys. 63 1 (1992) 101-110
51. Stearns R.C., Paulauskis J.D., and Godleski J.J. Endocytosis of ultrafine particles by A549 cells. Am. J. Respir. Cell Mol. Biol. 24 (2001) 108-115
52. Steenland K., and Brown D. Silicosis among gold miners: exposure-response analyses and risk assessment. Am. J. Public Health 85 10 (1995) 1372-1377
53. Steenland K., Mannetje A., Boffetta P., Stayner L., Attfield M., Chen J., Dosemeci M., DeKlerk N., Hnizdo E., Koskela R., Checkoway H., and IARC. Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control 12 9 (2001) 773-784
54. Steenland K. One agent, many diseases: exposure-response data and comparative risks of different outcomes following silica exposure. Am. J. Ind. Med. 48 1 (2005) 16-23
55. Thibodeau M.S., Giardina C., Knecht D., Helble J., and Hubbard A.K. Silica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. Toxicol. Sci. 80 (2004) 34-48
56. 't Mannetje A., Steenland K., Attfield M., Boffetta P., Checkoway H., DeKlerk N., and Koskela R.S. Exposure-response analysis and risk assessment for silica and silicosis mortality in a pooled analysis of six cohorts. Occup. Environ. Med. 59 (2002) 723-728
57. Travaglione S., Bruni B., Falzano L., Paoletti L., and Fiorentini C. Effects of the new-identified amphibole fluoro-edenite in lung epithelial cells. Toxicol. In Vitro 17 (2003) 547-552
58. Wilbourn J.D., McGregor D.B., Partensky C., and Rice J.M. IARC reevaluates silica and related substances. Environ. Health Perspect. 105 (1997) 756-759
59. Yamano Y., Kagawa J., Hanaoka T., Takahashi T., Kasai H., Tsugane S., and Watanabe S. Oxidative DNA damage induced by silica in vivo. Environ. Res. 69 (1995) 102-107
60. Zhang Z., Shen H.-M., Zhang Q.-F., and Ong C.-N. Involvement of oxidative stress in crystalline silica-induced cytotoxicity and genotoxicity in rat alveolar macrophages. Environ. Res. Sect. A 82 (2000) 245-252
61. Zhong B., Whong W., and Ong T. Detection of mineral-dust-induced DNA damage in two mammalian cell lines using the alkaline single cell gel/comet assay. Mutat. Res. 393 (1997) 181-187