Inhibition of human corneal epithelial production of fibrotic mediator TGF-β2 by basement membrane-like extracellular matrix

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 3, 2007, Pages 1061-1071

  LaGier, Adriana J ^a   Yoo, Sonia H ^a   Alfonso, Eduardo C ^a   Meiners, Sally ^b   Fini, M Elizabeth ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; EZRIN; GROWTH FACTOR; LAMININ; MATRIGEL; MESSENGER RNA; MOESIN; RADIXIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; BIOMATERIAL; COLLAGEN; CYTOSKELETON PROTEIN; PROTEOGLYCAN;

ARTICLE; BASEMENT MEMBRANE; CELL CULTURE; CELL POLARITY; CORNEA CELL; CORNEA EPITHELIUM; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THREE DIMENSIONAL IMAGING; TRANSCRIPTION INITIATION; CELL LINE; DRUG COMBINATION; DRUG EFFECT; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; PATHOLOGY;

BIOCOMPATIBLE MATERIALS; CELL LINE; COLLAGEN; CYTOSKELETAL PROTEINS; DRUG COMBINATIONS; EPITHELIUM, CORNEAL; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; LAMININ; PROTEOGLYCANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA2;

EID: 34047246332     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0772     Document Type: Article

References (56)

1. Cintron C, Kublin CL. Regeneration of corneal tissue. Dev Biol. 1977;61:346-357.
2. Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999;18:529-551.
3. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994;124:401-404.
4. Weimar V. Healing Processes in the Cornea. Oxford, UK: Blackwell Scientific Publications; 1960:111-124.
5. Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359:839-850.
6. Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 2005;13:7-12.
7. Martin P. Wound healing: aiming for perfect skin regeneration. Science. 1997;276:75-81.
8. Møller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Neutralizing antibody to TGFβ modulates stromal fibrosis but not regression of photoablative effect following PRK. Curr Eye Res. 1998;17:736-747.
9. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738-746.
10. Wilson SE, Mohan RR, Mohan RR, Ambrosio R Jr, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001;20:625-637.
11. Fini ME, Stramer BM. How the cornea heals: cornea-specific repair mechanisms impacting on surgical outcomes. Cornea. 2005;24(suppl 8):S2-S11.
12. Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003;44:4237-4246.
13. Klenkler B, Sheardown H. Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathology. Exp Eye Res. 2004;79:677-688.
14. Strissel KJ, Rinehart WB, Fini ME. A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-β2. Invest Ophthalmol Vis Sci. 1995;36:151-162.
15. Strissel KJ, Rinehart WB, Fini ME. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci. 1997;38:546-552.
16. Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT. Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci. 2003;44:3394-3401.
17. Stramer BM, Austin JS, Roberts AB, Fini ME. Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J Cell Physiol. 2005;203:226-232.
18. Sobrin L, Liu Z, Monroy DC, et al. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000;41:1703-1709.
19. Kruse FE, Tseng SC. Serum differentially modulates the clonal growth and differentiation of cultured limbal and corneal epithelium. Invest Ophthalmol Vis Sci. 1993;34:2976-2989.
20. Taub M, Wang Y, Szczesny TM, Kleinman HK. Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium. Proc Natl Acad Sci USA. 1990;87:4002-4006.
21. Ahmed I, Liu HY, Mamiya PC, et al. Three-dimensional nanofibrillar surfaces covalently modified with tenascin-C-derived peptides enhance neuronal growth in vitro. J Biomed Mater Res A. 2006;76:851-860.
22. Noma T, Glick AB, Geiser AG, et al. Molecular cloning and structure of the human transforming growth factor-β2 gene promoter. Growth Factors. 1991;4:247-255.
23. Brand T, Schneider MD. Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription. J Biol Chem. 1995;270:8274-8284.
24. Hayashi K, Frangieh G, Wolf G, Kenyon KR. Expression of transforming growth factor-β in wound healing of vitamin A-deficient rat corneas. Invest Ophthalmol Vis Sci. 1989;30:239-247.
25. Li DQ, Tseng SC. Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol. 1995;163:61-79.
26. Nishida K, Sotozono C, Adachi W, Yamamoto S, Yokoi N, Kinoshita S. Transforming growth factor-β1, -β2 and -β3 mRNA expression in human cornea. Curr Eye Res. 1995;14:235-241.
27. Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. Immunolocalization of TGF-β1, TGF-β2, and TGF-β3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993;34:23-30.
28. Wilson SE, He YG, Lloyd SA. EGF, EGF receptor, basic FGF, TGF β-1, and IL-1 alpha mRNA in human corneal epithelial cells and stromal fibroblasts. Invest Ophthalmol Vis Sci. 1992;33:1756-1765.
29. Wilson SE, Lloyd SA, He YG. EGF, basic FGF, and TGF β-1 messenger RNA production in rabbit corneal epithelial cells. Invest Ophthalmol Vis Sci. 1992;33:1987-1995.
30. Wilson SE, Schultz GS, Chegini N, Weng J, He YG. Epidermal growth factor, transforming growth factor alpha, transforming growth factor β, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res. 1994;59:63-71.
31. Schermer A, Galvin S, Sun TT. Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol. 1986;103:49-62.
32. Colvin RB. Fibronectin. New York: Academic Press; 1989:213-252.
33. Nabi IR, Mathews AP, Cohen-Gould L, Gundersen D, Rodriguez-Boulan E. Immortalization of polarized rat retinal pigment epithelium. J Cell Sci. 1993;104:37-49.
34. Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: implications for development. Dev Biol. 1991;143:303-308.
35. Schindler M, Nur EKA, Ahmed I, et al. Living in three dimensions: 3-D nanostructured environments for cell culture and regenerative medicine. Cell Biochem Biophys. 2006;45.215-228.
36. Schindler M, Ahmed I, Kamal J, et al. A synthetic nanofibrillar matrix promotes in vivo-like organization and morphogenesis for cells in culture. Biomaterials. 2005;26:5624-5631.
37. Nur EKA, Ahmed I, Kamal J, Schindler M, Meiners S. Three dimensional nanofibrillar surfaces induce activation of Rac. Biochem Biophys Res Commun. 2005;331:428-434.
38. Bhowmick NA, Ghiassi M, Bakin A, et al. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell. 2001;12:27-36.
39. Wakefield LM, Roberts AB. TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev. 2002;12:22-29.
40. Bonilha VL, Finnemann SC, Rodriguez-Boulan E. Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium. J Cell Biol. 1999;147:1533-1548.
41. O'Toole EA, Marinkovich MP, Hoeffler WK, Furthmayr H, Woodley DT. Laminin-5 inhibits human keratinocyte migration. Exp Cell Res. 1997;233:330-339.
42. Takeuchi K, Sato N, Kasahara H, et al. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J Cell Biol. 1994;125:1371-1384.
43. Wick W, Grimmel C, Wild-Bode C, Platten M, Arpin M, Weller M. Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-β2. J Neurosci. 2001;21:3360-3368.
44. Wakefield LM, Smith DM, Flanders KC, Sporn MB. Latent transforming growth factor-β from human platelets: a high molecular weight complex containing precursor sequences. J Biol Chem. 1988;263:7646-7654.
45. Miyazono K, Thyberg J, Heldin CH. Retention of the transforming growth factor-β 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form. J Biol Chem. 1992;267:5668-5675.
46. Miyazono K, Olofsson A, Colosetti P, Heldin CH. A role of the latent TGF-β 1-binding protein in the assembly and secretion of TGF-β 1. EMBO J. 1991;10:1091-1101.
47. Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB. Recombinant latent transforming growth factor β1 has a longer plasma half-life in rats than active transforming growth factor β1, and a different tissue distribution. J Clin Invest. 1990;86:1976-1984.
48. Kim SJ, Park K, Koeller D, et al. Post-transcriptional regulation of the human transforming growth factor-β1 gene. J Biol Chem. 1992;267:13702-13707.
49. Bretscher A, Reczek D, Berryman M. Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci. 1997;110:3011-3018.
50. Hall A. Rho GTPases and the actin cytoskeleton. Science. 1998;279:509-514.
51. Calderwood DA, Shattil SJ, Ginsberg MH. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J Biol Chem. 2000;275:22607-22610.
52. Pokutta S, Weis WI. The cytoplasmic face of cell contact sites. Curr Opin Struct Biol. 2002;12:255-262.
53. Tsukita S, Yonemura S. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem. 1999;274:34507-34510.
54. Gautreau A, Louvard D, Arpin M. ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling. Curr Opin Cell Biol. 2002;14:104-109.
55. Louvet-Vallee S. ERM proteins, from cellular architecture to cell signaling. Biol Cell. 2000;92:305-316.
56. Belkin AM, Stepp MA. Integrins as receptors for laminins. Microsc Res Tech. 2000;51:280-301.