MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis

Journal of Infectious Diseases

Volumn 195, Issue 8, 2007, Pages 1189-1193

  Klein, Matthias ^a   Schmidt, Caroline ^a   Kastenbauer, Stefan ^a   Paul, Robert ^a   Kirschning, Carsten J ^b   Wagner, Hermann ^b   Popp, Bernadette ^a   Pfister, Hans Walter ^a,c   Koedel, Uwe ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; MYELOID DIFFERENTIATION FACTOR 88;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOMETRY; BACTERIAL MENINGITIS; HAIR CELL; HEARING LOSS; HISTOLOGY; IMMUNE RESPONSE; INNER EAR DISEASE; LABYRINTHITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPIRAL GANGLION; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; AUDITORY THRESHOLD; COCHLEA; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING LOSS; LABYRINTHITIS; MENINGITIS, PNEUMOCOCCAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; SPIRAL GANGLION;

EID: 34047238623     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/512859     Document Type: Article

References (15)

1. Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 2003; 126:1015-25.
2. Merchant SN, Gopen Q. A human temporal bone study of acute bacterial meningogenic labyrinthitis. Am J Otol 1996; 17:375-85.
3. Klein M, Koedel U, Pfister HW, Kastenbauer S. Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis. Brain Pathol 2003; 13:1-10.
4. Koedel U, Angele B, Rupprecht T, et al. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal men-ingitis. J Immunol 2003; 170:438-44.
5. Koedel U, Rupprecht T, Angele B, et al. MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Brain 2004; 127(Pt 6):1437-45.
6. Ge NN, Brodie SA, Tinling SP, Brodie HA. The effects of superoxide dismutase in gerbils with bacterial meningitis. Otolaryngol Head Neck Surg 2004; 131:563-72.
7. Rappaport JM, Bhatt SM, Burkard RF, Merchant SN, Nadol JB. Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis 1999; 179: 264-8.
8. Winter AJ, Marwick S, Osborne M, Comis S, Stephen J, Tarlow M. Ultrastructural damage to the organ of corti during acute experimental Escherichia coli and pneumococcal meningitis in guinea pigs. Acta Otolaryngol 1996; 116:401-7.
9. Meli DN, Coimbra RS, Erhart DG, et al. Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis. Infect Immun 2006; 74:3890-6.
10. Klein M, Koedel U, Pfister HW, Kastenbauer S. Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy. Ann Neurol 2003; 54:451-8.
11. Schroder NW, Morath S, Alexander C, et al. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 2003; 278:15587-94.
12. Malley R, Henneke P, Morse SC, et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci USA 2003; 100:1966-71.
13. Koedel U, Winkler F, Angele B, Fontana A, Flavell RA, Pfister HW. Role of caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic caspase inhibition and caspase-1-deficient mice. Ann Neurol 2002;51:319- 29.
14. Yeung AH, Tinling SP, Brodie HA. Inhibition of post-meningitic cochlear injury with cerebrospinal fluid irrigation. Otolaryngol Head Neck Surg 2006; 134:214-24.
15. Bhatt SM, Lauretano A, Cabellos C, et al. Progression of hearing loss in experimental pneumococcal meningitis: correlation with cerebrospinal fluid cytochemistry. J Infect Dis 1993; 167:675-83.