Hypertonic saline treatment of cystic fibrosis

Annals of Pharmacotherapy

Volumn 41, Issue 3, 2007, Pages 481-484

  Taylor, Lisa M ^a   Kuhn, Robert J ^b,c  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^c University of Kentucky   (United States)

Author keywords

Cystic fibrosis; Hypertonic saline

Indexed keywords

AMILORIDE; CHLORIDE; DEOXYRIBONUCLEASE I; SALBUTAMOL; SODIUM CHLORIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTHRALGIA; CHEST TIGHTNESS; CHLORIDE TRANSPORT; CYSTIC FIBROSIS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG WITHDRAWAL; FORCED EXPIRATORY VOLUME; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; LUNG FUNCTION; MEDLINE; MUCOCILIARY CLEARANCE; NEBULIZATION; PHARYNGITIS; PHARYNX DISCOMFORT; PRIORITY JOURNAL; QUALITY OF LIFE; REGULATOR GENE; RESPIRATORY TRACT DISEASE; REVIEW; SODIUM ABSORPTION; SURVIVAL RATE; THORAX PAIN; TONSILLITIS; TREATMENT DURATION; TREATMENT OUTCOME;

CLINICAL TRIALS; CYSTIC FIBROSIS; HUMANS; SALINE SOLUTION, HYPERTONIC;

EID: 34047234121     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1H425     Document Type: Review

References (17)

1. Ratjen F, Doring G. Cystic fibrosis. Lancet 2003;361:681-9.
2. Cystic Fibrosis Foundation patient registry annual data report 2004. Bethesda, MD: Cystic Fibrosis Foundation, 2004.
3. Cystic Fibrosis Foundation annual report 2005. Bethesda, MD: Cystic Fibrosis Foundation, 2005.
4. Kulich M, Rosenfeld M, Goss C, Wilmott R. Improved survival among young patients with cystic fibrosis. J Pediatr 2003;142:631-6.
5. Daviskas E, Anderson SD. Hyperosmolar agents and clearance of mucus in the diseased airway. J Aerosol Med 2006;19:100-9.
6. Riedler J, Reade T, Button B, Robertson CF. Inhaled hypertonic saline increases sputum expectoration in cystic fibrosis. J Paediatr Child Health 1996;32:48-50.
7. Sagel SD, Kapsner R, Osberg I, Sontag MK, Accurso FJ. Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction. Am J Respir Crit Care Med 2001;164:1425-31.
8. Sagel SD, Sontag MK, Wagener JS, Kapsner RK, Osberg I, Accurso FJ. Induced sputum inflammatory measures correlate with lung function in children with cystic fibrosis. J Pediatr 2002;141:811-7.
9. Eng PA, Morton J, Douglass JA, Riedler J, Wilson J, Robertson CF. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 1996;21:77-83.
10. Elkins MR, Robinson M, Rose BR, et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 2006;354:229-40.
11. Ratjen F. Restoring airway surface liquid in cystic fibrosis. N Engl J Med 2006;354:291-3.
12. Robinson M, Hemming AL, Regnis JA, et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 1997;52:900-3.
13. Robinson M, Regnis JA, Bailey DL, King M, Bautovich GJ, Bye PT. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 1996;153: 1503-9.
14. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 2006;354:241-50.
15. Cystic Fibrosis Services. Hypertonic saline kit. www.cfservicespharmacy. com (accessed 2006 Jun 27).
16. Rodwell LT, Anderson SD. Airway responsiveness to hyperosmolar saline challenge in cystic fibrosis: a pilot study. Pediatr Pulmonol 1996; 21:282-9.
17. Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med 1994;331:637-42.