Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 2, 2007, Pages 183-206

  Vermeulen, An ^a   Piotrovsky, Vladimir ^a   Ludwig, Elizabeth A ^b  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Albany Medical College   (United States)

Author keywords

9 hydroxyrisperidone; Population pharmacokinetics; Risperidone

Indexed keywords

CARBAMAZEPINE; CYTOCHROME P450 2D6; PALIPERIDONE; PLACEBO; PROTEIN; RISPERIDONE;

ADULT; AGED; ARTICLE; BIPOLAR I DISORDER; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COVARIANCE; CREATININE CLEARANCE; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DOSE REGIMEN; ENZYME POLYMORPHISM; FEMALE; HUMAN; INTERRATER RELIABILITY; INTRARATER RELIABILITY; KNOWLEDGE; LABORATORY TEST; LEAN BODY WEIGHT; LINEAR REGRESSION ANALYSIS; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PHENOTYPE; PLASMA CONCENTRATION-TIME CURVE; POPULATION MODEL; PRIORITY JOURNAL; RACE; SEX; SIMULATION;

ACUTE DISEASE; ADMINISTRATION, ORAL; ADULT; AGED; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; COMPUTER SIMULATION; CYTOCHROME P-450 CYP2D6; DATABASES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; ISOXAZOLES; LINEAR MODELS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; PHENOTYPE; POPULATION SURVEILLANCE; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; RISPERIDONE; TABLETS;

EID: 34047225130     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-006-9040-2     Document Type: Article

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