Ocular ischemic syndrome: Review of clinical presentations, etiology, investigation, and management

Comprehensive Ophthalmology Update

Volumn 8, Issue 1, 2007, Pages 17-28

  Chen, Cella S ^a   Miller, Neil R ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Carotid artery occlusion; Neovascularization; Ocular ischemic syndrome (OIS); Ophthalmic artery vasculitis

Indexed keywords

ALCOHOL; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBONATE DEHYDRATASE INHIBITOR; CHLORPROMAZINE; STEROID;

CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CENTRAL RETINA ARTERY OCCLUSION; CENTRAL RETINA VEIN OCCLUSION; CLINICAL FEATURE; CLINICAL TRIAL; COMORBIDITY; DIABETIC RETINOPATHY; DIFFERENTIAL DIAGNOSIS; DOPPLER FLOWMETRY; EYE INJURY; EYE PAIN; FLUORESCENCE ANGIOGRAPHY; GIANT CELL ARTERITIS; HUMAN; INTRAOCULAR PRESSURE; IRIDOCYCLITIS; ISCHEMIC OPTIC NEUROPATHY; NEOVASCULARIZATION (PATHOLOGY); OCULAR ISCHEMIC SYNDROME; PROGNOSIS; RETINA ISCHEMIA; RETINOPATHY; REVIEW; SCLERODERMA; TRABECULECTOMY; TRANSITIONAL BLINDNESS; VASCULAR DISEASE; VASCULITIS; VISUAL ACUITY; VISUAL IMPAIRMENT;

ANGIOGRAPHY; ANTICOAGULANTS; ARTERIAL OCCLUSIVE DISEASES; CAROTID ARTERY, INTERNAL; CAROTID STENOSIS; ENDARTERECTOMY, CAROTID; EYE; FLUORESCEIN ANGIOGRAPHY; FUNDUS OCULI; HUMANS; ISCHEMIA; OPHTHALMIC ARTERY; ORBIT; PROGNOSIS; SYNDROME; ULTRASONOGRAPHY, DOPPLER, DUPLEX;

EID: 34047219721     PISSN: 15277313     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Brown GC, Magargal LE: The ocular ischemic syndrome. Clinical, fluorescein angiographic and carotid angiographic features. Int Ophthalmol 11: 239-51, 1988
2. Kearns TP, Hollenhorst RW: Venous-stasis retinopathy of occlusive disease of the carotid artery Mayo Clin Proc 38: 304-12, 1963
3. Knox DL: Ischemic ocular inflammation. Am J Ophthalmol 60: 995-1002, 1965
4. Sivalingam A, Brown GC, Magargal LE, et al: The ocular ischemic syndrome. II. Mortality and systemic morbidity. Int Ophthalmol 13: 187-91, 1989
5. Biousse V: Carotid disease and the eye. Curr Opin Ophthalmol 8: 16-26, 1997
6. Brown GC, Brown MM, Magargal LE: The ocular ischemic syndrome and neovascularization. Trans Pa Acad Ophthalmol Otolaryngol 38: 302-6, 1986
7. Mizener JB, Podhajsky P, Hayreh SS: Ocular ischemic syndrome. Ophthalmology 104: 859-64, 1997
8. Kaiboriboon K, Piriyawat P, Selhorst JB: Light-induced amaurosis fugax. Am J Ophthalmol 131: 674-6, 2001
9. Levin LA, Mootha VV: Postprandial transient visual loss. A symptom of critical carotid stenosis. Ophthalmology 104: 397-401, 1997
10. Brown GC, Magargal LE, Simeone FA, et al: Arterial obstruction and ocular neovascularization. Ophthalmology 89: 139-46, 1982
11. Mills RP: Anterior segment ischemia secondary to carotid occlusive disease. J Clin Neuroophthalmol 9: 200-4, 1989
12. Malhotra R, Gregory-Evans K: Management of ocular ischaemic syndrome. Br J Ophthalmol 84: 1428-31, 2000
13. Countee RW, Gnanadev A, Chavis P: Dilated episcleral arteries - a significant physical finding in assessment of patients with cerebrovascular insufficiency. Stroke 9: 42-5, 1978
14. Gross R: Neovascular glaucoma and ocular ischemic syndrome. J Glaucoma 9: 409-12, 2000
15. Biousse V: Cerebrovascular disease, in Miller NR, Newman NJ (eds): Walsh & Hoyt's Clinical Neurophthalmology. Philadelphia, Lippincott Williams & Wilkins, 2004, pp 1967-2168
16. Brown GC: Anterior ischemic optic neuropathy occurring in association with carotid artery obstruction. J Clin Neuroophthalmol 6: 39-42, 1986
17. Kawasaki A: Disorders of pupillary function, accommodation and lacrimation, in Miller NR, Newman NJ (eds): Walsh & Hoyt's Clinical Neuro-Ophthalmology. Philadelphia, Lippincott Williams & Wilkins, 2004, pp 739-805
18. Esteban A, Traba A, Prieto J: Eyelid movements in health and disease. The supranuclear impairment of the palpebral motility. Neurophysiol Clin 34: 3-15, 2004
19. Lapresle J, Lasjaunias P: Cranial nerve ischaemic arterial syndromes. A review. Brain 109 (Pt 1): 207-16, 1986
20. Kerty E, Hørven I: Ocular hemodynamic changes in patients with high-grade carotid occlusive disease and development of chronic ocular ischaemia. I. Doppler and dynamic tonometry findings. Acta Ophthalmol Scand 73: 66-71, 1995
21. Hayreh SS: Arteries of the orbit in the human being. Br J Surg 50: 938-53, 1963
22. Karacostas D, Terzidou C, Voutas S, et al: Isolated ocular ischemic syndrome with no cerebral involvement in common carotid artery occlusion. Eur J Ophthalmol 11: 97-101, 2001
23. Alizai AM, Trobe JD, Thompson BG, et al: Ocular ischemic syndrome after occlusion of both external carotid arteries. J Neuroophthalmol 25: 268-72, 2005
24. Durrani OM, Gordon C, Murray PI: Primary anti-phospholipid antibody syndrome (APS): current concepts. Surv Ophthalmol 47: 215-38, 2002
25. Imrie FR, Hammer HM, Jay JL: Bilateral ocular ischaemic syndrome in association with hyperhomocysteinaemia. Eye 16: 497-500, 2002
26. Puri P, Squirrell D: The role of IgM isotype anticardiolipin antibodies in ocular vaso-occlusive disease. Eye 15: 365, 2001
27. Barrall JL, Summers CG: Ocular ischemic syndrome in a child with moyamoya disease and neurofibromatosis. Surv Ophthalmol 40: 500-4, 1996
28. Shuto T, Yamamoto I: Ocular ischaemia with hypoplasia of the internal carotid artery associated with neurofibromatosis type 1. Acta Neurochir (Wien) 142: 353-4, 2000
29. Ino-ue M, Azumi A, Kajiura-Tsukahara Y, et al: Ocular ischemic syndrome in diabetic patients. Jpn J Ophthalmol 43: 31-5, 1999
30. Hwang JM, Girkin CA, Perry JD, et al: Bilateral ocular ischemic syndrome secondary to giant cell arteritis progressing despite corticosteroid treatment. Am J Ophthalmol 127: 102-4, 1999
31. Worrall M, Atebara N, Meredith T, et al: Bilateral ocular ischemic syndrome in Takayasu disease. Retina 21: 75-6, 2001
32. Schmidt MH, Fox AJ, Nicolle DA: Bilateral anterior ischemic optic neuropathy as a presentation of Takayasu's disease. J Neuroophthalmol 17: 156-61, 1997
33. Cheng KS, Tiwari A, Boutin A, et al: Carotid and femoral arterial wall mechanics in scleroderma. Rheumatology (Oxford) 42: 1299-305, 2003
34. Konuk O, Ozdek S, Onal B, et al: Ocular ischemic syndrome presenting as central retinal artery occlusion in scleroderma. Retina 26: 102-4, 2006
35. Liegl O: [Double-sided occlusion of the great vessels of the neck after X-ray treatment in childhool (author's transl)]. Klin Monatsbl Augenheilkd 167: 704-14, 1975
36. Williams EL: Postoperative blindness. Anesthesiol Clin North America 20: 605-622, viii, 2002
37. Leibovitch I, Casson R, Laforest C, et al: Ischemic orbital compartment syndrome as a complication of spinal surgery in the prone position. Ophthalmology 113: 105-8, 2006
38. Bekar A, Türeyen K, Aksoy K: Unilateral blindness due to patient positioning during cervical syringomyelia surgery: unilateral blindness after prone position. J Neurosurg Anesthesiol 8: 227-9, 1996
39. Kumar N, Jivan S, Topping N, et al: Blindness and rectus muscle damage following spinal surgery. Am J Ophthalmol 138: 889-91, 2004
40. American Society of Anesthesiologists: Practice advisory for perioperative visual loss associated with spine surgery: a report by the American Society of Anesthesiologists Task Force on Perioperative Blindness. Anesthesiology 104: 1319-28, 2006
41. Shortt AJ, Fulcher T, Conroy D: Ocular ischaemic syndrome in thyroid eye disease, confirmed using magnetic resonance angiography. Br J Ophthalmol 87: 1302-3, 2003
42. Kussmaul A: Zwei Falle von Spontaner Allmaliger Verschliessung grosser Halsarterienstamme. Dtsch Klinik 24: 461-5, 1872
43. Yu Q, Wang P, Shi H, et al: Carotid artery and jugular vein invasion of oral-maxillofacial and neck malignant tumors: diagnostic value of computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96: 368-72, 2003
44. Kearns TP: Differential diagnosis of central retinal vein obstruction. Ophthalmology 90: 475-80, 1983
45. Utsugi N, Takahashi K, Kishi S: Choroidal vascular occlusion in internal carotid artery obstruction. Retina 24: 915-9, 2004
46. Ho AC, Lieb WE, Flaharty PM, et al: Color Doppler imaging of the ocular ischemic syndrome. Ophthalmology 99: 1453-62, 1992
47. Williamson TH, Harris A: Color Doppler ultrasound imaging of the eye and orbit. Surv Ophthalmol 40: 255-67, 1996
48. Ishikawa K, Kimura I, Shinoda K, et al: In situ confirmation of retinal blood flow improvement after carotid endarterectomy in a patient with ocular ischemic syndrome. Am J Ophthalmol 134: 295-7, 2002
49. Harris A, Arend O, Kopecky K, et al: Physiological perturbation of ocular and cerebral blood flow as measured by scanning laser ophthalmoscopy and color Doppler imaging. Surv Ophthalmol 38 Suppl: S81-6, 1994
50. Wardlaw JM, Chappell FM, Best JJ, et al: Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 367: 1503-12, 2006
51. Goldstein LB, Adams R, Alberts MJ, et al: Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: co-sponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc. Circulation 113: e873-923, 2006
52. Ros MA, Magargal LE, Hedges TR, et al: Ocular ischemic syndrome: long-term ocular complications. Ann Ophthalmol 19: 270-2, 1987
53. Johnston ME, Gonder JR, Canny CL: Successful treatment of the ocular ischemic syndrome with panretinal photocoagulation and cerebrovascular surgery. Can J Ophthalmol 23: 114-9, 1988
54. Coppeto JR, Wand M, Bear L, et al: Neovascular glaucoma and carotid artery obstructive disease. Am J Ophthalmol 99: 567-70, 1985
55. Sivak-Callcott JA, O'Day DM, Gass JD, et al: Evidence-based recommendations for the diagnosis and treatment of neovascular glaucoma. Ophthalmology 108: 1767-76; quiz1777, 1800, 2001
56. Tranos PG, Wickremasinghe SS, Stangos NT, et al: Macular edema. Surv Ophthalmol 49: 470-90, 2004
57. Klais CM, Spaide RF: Intravitreal triamcinolone acetonide injection in ocular ischemic syndrome. Retina 24: 459-61, 2004
58. Feltgen N, Neubauer A, Jurklies B, et al: Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1 : EAGLE Study report no. 1. Graefes Arch Clin Exp Ophthalmol 244: 950-6, 2006
59. Saha N, Rehman SU: Reversal of chronic ocular ischaemia with good visual recovery in giant cell arteritis. Eye 20: 742-3, 2006
60. Hamed LM, Guy JR, Moster ML, et al: Giant cell arteritis in the ocular ischemic syndrome. Am J Ophthalmol 113: 702-5, 1992
61. _: The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 349: 1569-81, 1997
62. Diener HC, Bogousslavsky J, Brass LM, et al: Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364: 331-7, 20042430
63. ESPRIT Study Group, Halkes PH, van Gijn J, et al: Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367: 1665-73, 2006
64. _: Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351: 1379-87, 1998
65. Morgenstern LB, Fox AJ, Sharpe BL, et al: The risks and benefits of carotid endarterectomy in patients with near occlusion of the carotid artery. North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group. Neurology 48: 911-5, 1997
66. Rothwell PM, Warlow CP: Prediction of benefit from carotid end-arterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists' Collaborative Group. Lancet 353: 2105-10, 1999
67. Wolintz RJ: Carotid endarterectomy for ophthalmic manifestations: is it ever indicated?. J Neuroophthalmol 25: 299-302, 2005
68. Rubin JR, McIntyre KM, Lukens MC, et al: Carotid endarterectomy for chronic retinal ischemia. Surg Gynecol Obstet 171: 497-501, 1990
69. Costa VP, Kuzniec S, Molnar LJ, et al: The effects of carotid end-arterectomy on the retrobulbar circulation of patients with severe occlusive carotid artery disease. An investigation by color Doppler imaging. Ophthalmology 106: 306-10, 1999
70. Sivalingam A, Brown GC, Magargal LE: The ocular ischemic syndrome. III. Visual prognosis and the effect of treatment. Int Ophthalmol 15: 15-20, 1991
71. Watanabe M, Ogino T, Kinoshita T, et al: Ocular findings and prognosis of ocular ischemic syndrome. Folia Ophthalmol Jpn 57: 189-94, 2006
72. Kawaguchi S, Sakaki T, Morimoto T, et al: Effects of bypass on ocular ischaemic syndrome caused by reversed flow in the ophthalmic artery. Lancet 354: 2052-3, 1999
73. Marx JL, Hreib K, Choi IS, et al: Percutaneous carotid artery angioplasty and stenting for ocular ischemic syndrome. Ophthalmology 111: 2284-91, 2004
74. Sytkowski PA, D'Agostino RB, Belanger A, et al: Sex and time trends in cardiovascular disease incidence and mortality: the Framingham Heart: Study, 1950-1989. Am J Epidemiol 143: 338-50, 1996