NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break

Biochemistry

Volumn 46, Issue 13, 2007, Pages 4158-4163

  Parsons, Jason L ^a   Kavli, Bodil ^b   Slupphaug, Geir ^b   Dianov, Grigory L ^a,c  

^a MRC Radiation And Genome Stability Unit   (United Kingdom)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIR PATHWAYS; DNA DAMAGE; DNA GLYCOSYLASE; DNA SUBSTRATES;

BIOCHEMISTRY; DNA SEQUENCES; GENETIC ENGINEERING; IONIZING RADIATION;

ENZYME KINETICS;

5 HYDROXYURACIL; DNA DIRECTED DNA POLYMERASE BETA; DNA GLYCOSYLTRANSFERASE; DNA LIGASE IIIALPHA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN NEIL1; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ANALYSIS; EXCISION REPAIR; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL;

DNA DAMAGE; DNA GLYCOSYLASES; DNA LIGASES; DNA POLYMERASE BETA; DNA REPAIR; HUMANS; URACIL; URACIL-DNA GLYCOSIDASE;

EID: 34047213485     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0622569     Document Type: Article

References (27)

1. Lindahl, T. (1993) Instability and decay of the primary structure of DNA, Nature 362, 709-715.
2. Wagner, J. R., Hu, C. C., and Ames, B. N. (1992) Endogenous oxidative damage of deoxycytidine in DNA, Proc. Natl. Acad. Sci. U.S.A. 89, 3380-3384.
3. Kreutzer, D. A., and Essigmann, J. M. (1998) Oxidized, deaminated cytosines are a source of C → T transitions in vivo, Proc. Natl. Acad. Sci. U.S.A. 95, 3578-3582.
4. Ward, J. F. (1995) Radiation mutagenesis: The initial DNA lesions responsible, Radiat. Res. 142, 362-368.
5. Yang, N., Chaudhry, M. A., and Wallace, S. S. (2006) Base excision repair by hNTH1 and hOGG1: A two edged sword in the processing of DNA damage in γ-irradiated human cells, DNA Repair 5, 43-51.
6. Eot-Houllier, G., Eon-Marchais, S., Gasparutto, D., and Sage, E. (2005) Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins, Nucleic Acids Res. 33, 260-271.
7. Dianov, G. L., Timchenko, T. V., Sinitsina, O. I., Kuzminov, A. V., Medvedev, O. A., and Salganik, R. I. (1991) Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation, Mol. Gen. Genet. 225, 448-452.
8. Dianov, G. L., O'Neill, P., and Goodhead, D. T. (2001) Securing genome stability by orchestrating DNA repair: Removal of radiation-induced clustered lesions in DNA, BioEssays 23, 745-749.
9. Weinfeld, M., Rasouli-Nia, A., Chaudhry, M. A., and Britten, R. A. (2001) Response of base excision repair enzymes to complex DNA lesions, Radiat. Res. 156, 584-589.
10. Blaisdell, J. O., Harrison, L., and Wallace, S. S. (2001) Base excision repair processing of radiation-induced clustered DNA lesions, Radiat. Prot. Dosim. 97, 25-31.
11. Lindahl, T., and Wood, R. D. (1999) Quality Control by DNA Repair, Science 286, 1897-1905.
12. Dianov, G., Price, A., and Lindahl, T. (1992) Generation of single-nucleotide repair patches following excision of uracil residues from DNA, Mol. Cell. Biol. 12, 1605-1612.
13. Katafuchi, A., Nakano, T., Masaoka, A., Terato, H., Iwai, S., Hanaoka, F., and Ide, H. (2004) Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions, J. Biol. Chem. 279, 14464-14471.
14. Parsons, J. L., Zharkov, D. O., and Dianov, G. L. (2005) NEIL1 excises 3′ end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1, Nucleic Acids Res. 33, 4849-4856.
15. Slupphaug, G., Eftedal, I., Kavli, B., Bharati, S., Helle, N. M., Haug, T., Levine, D. W., and Krokan, H. E. (1995) Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase, Biochemistry 34, 128-138.
16. Haushalter, K. A., Stukenberg, P. T., Kirschner, M. W., and Verdine, G. L. (1999) Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors, Curr. Biol. 9, 174-185.
17. Kavli, B., Sundheim, O., Akbari, M., Otterlei, M., Nilsen, H., Skorpen, F., Aas, P. A., Hagen, L., Krokan, H. E., and Slupphaug, G. (2002) hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup, J. Biol. Chem. 277, 39926-39936.
18. Dizdaroglu, M., Karakaya, A., Jaruga, P., Slupphaug, G., and Krokan, H. E. (1996) Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage, Nucleic Acids Res. 24, 418-422.
19. Masaoka, A., Matsubara, M., Hasegawa, R., Tanaka, T., Kurisu, S., Terato, H., Ohyama, Y., Karino, N., Matsuda, A., and Ide, H. (2003) Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions, Biochemistry 42, 5003-5012.
20. Kavli, B., Andersen, S., Otterlei, M., Liabakk, N. B., Imai, K., Fischer, A., Durandy, A., Krokan, H. E., and Slupphaug, G. (2005) B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil, J. Exp. Med. 201, 2011-2021.
21. Manley, J. L., Fire, A., Samuels, M., and Sharp, P. A. (1983) In vitro transcription: Whole-cell extract, Methods Enzymol. 101, 568-582.
22. Parsons, J. L., Dianova, I. I., and Dianov, G. L. (2005) APE1-dependent repair of DNA single-strand breaks containing 3′-end 8-oxoguanine, Nucleic Acids Res. 33, 2204-2209.
23. Ali, M. M., Hazra, T. K., Hong, D., and Kow, Y. W. (2005) Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil, DNA Repair 4, 679-686.
24. Wiederhold, L., Leppard, J. B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., Mitra, S., and Hazra, T. K. (2004) AP endonuclease-independent DNA base excision repair in human cells, Mol. Cell 15, 209-220.
25. An, Q., Robins, P., Lindahl, T., and Barnes, D. E. (2005) C → T mutagenesis and γ-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases, EMBO J. 24, 2205-2213.
26. Rosenquist, T. A., Zaika, E., Fernandes, A. S., Zharkov, D. O., Miller, H., and Grollman, A. P. (2003) The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death, DNA Repair 2, 581-591.
27. Gulston, M., de Lara, C., Jenner, T., Davis, E., and O'Neill, P. (2004) Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation, Nucleic Acids Res. 32, 1602-1609.