Thrombophilia and adverse maternal-perinatal outcome: Controversies in screening and management

American Journal of Perinatology

Volumn 23, Issue 8, 2006, Pages 499-506

  Stella, Caroline L ^a   How, Helen Y ^a   Sibai, Baha M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Adverse pregnancy outcome; Thrombophilia

Indexed keywords

ACETYLSALICYLIC ACID; ENOXAPARIN; FOLIC ACID; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PHOSPHOLIPID ANTIBODY; PREDNISONE;

ANTIPHOSPHOLIPID SYNDROME; CLINICAL TRIAL; FETUS WASTAGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; LOW DRUG DOSE; OUTCOME ASSESSMENT; PERINATAL PERIOD; PREECLAMPSIA; PREGNANCY OUTCOME; PRIORITY JOURNAL; REVIEW; SCREENING; SOLUTIO PLACENTAE; SYSTEMATIC REVIEW; THROMBOPHILIA; BIRTH; COUNSELING; FEMALE; FETUS DEATH; INCIDENCE; PREGNANCY; PREGNANCY COMPLICATION;

ABRUPTIO PLACENTAE; ANTIPHOSPHOLIPID SYNDROME; COUNSELING; FEMALE; FETAL DEATH; FETAL GROWTH RETARDATION; HUMANS; INCIDENCE; PARTURITION; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME; THROMBOPHILIA;

EID: 34047196235     PISSN: 07351631     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-954961     Document Type: Review

References (62)

1. Paidas MJ, De-Hui WK, Arkel YS. Screening and management of inherited thrombophilias in the setting of adverse pregnancy outcome. Clin Perinatol 2004;31:783-805
2. Barbour LA. Thromboembolism in pregnancy. ACOG Committee in Obstetric Practice Bulletin. Number 19. Washington, DC: The College; 2000
3. Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a metaanalysis. Lancet 2003;361:901-908
4. Ridker PM, Miletich JP, Hennekens CH, Burring JE. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA 1997;277:1305-1307
5. Dizon-Townson D, Miller C, Sibai B, et al. The relationship of factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol 2005;106:517-524
6. Lockwood CJ. Inherited thrombophilias in pregnant patients. Prenat Neonat Med 2001;6:3-14
7. Greer IA. Thrombophilia: implications for pregnancy outcome. Thromb Res 2003;109:73-81
8. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999;353:1167-1173
9. Lee RM, Brown MA, Branch DW, Ward K, Silver RM. Anticardiolipin and anti- B2 glycoprotein-I antibodies in preeclampsia. Obstet Gynecol 2003;102:294-300
10. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004;191:412-424
11. Lin L, August P. Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol 2005;105:182-192
12. Mignini LE, Latthe PM, Villar J, Killy MD, Carroli G, Khan KS. Mapping the theories of preeclampsia: the role of homocysteine. Obstet Gynecol 2005;105:411-425
13. Ananth CV. Placental abruption and perinatal mortality in the United States. Am J Epidemiol 2001;153:332-337
14. Branch DW, Porter TF, Rittenhouse L, et al. Antiphospholipid antibodies in women at risk for preeclampsia. Am J Obstet Gynecol 2001;184:825-834
15. Dreyfus M, Hedelin G, Kutnahorsky R, et al. Antiphospholipid antibodies and preeclampsia: a case-control study. Obstet Gynecol 2001;97:29-34
16. 2-glycoprotein-1 antibodies in preeclampsia. Obstet Gynecol 2003;102:294-300
17. Esplin MS. Antiphospholipid syndrome. ACOG Practice Bulletin No. 68. Obstet Gynecol 2005;106:1113-1121
18. Dekker GA, de Vries JI, Doelitzsch PM, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042-1048
19. Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996;175:902-905
20. Riyazi N, Leeda M, de Vries JIP, Huijgens PC, van Geijn HP, Dekker GA. Low molecular weight heparin combines with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study. Eur J Obstet Gynecol Reprod Biol 1998;80:49-54
21. Nagy B, Toth T, Rigo J Jr, Karadi I, Romics L, Papp Z. Detection of factor V Leiden mutation in severe preeclamptic Hungarian women. Clin Genet 1998;53:478-481
22. Krauss T, Augustin HG, Osmers R, Meden H, Unterhalt M, Kuhn W. Activated protein C resistance and factor V Leiden in patients with hemolysis, elevated liver enzymes, low platelets syndrome. Obstet Gynecol 1998;92:457-460
23. Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999;340:9-13
24. van Pampus EC, Dekker GA, Wolf, et al. High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia. Am J Obstet Gynecol 1999;180:1146-1150
25. DeGroot CJ, Bloemankamp KW, Duvekot EJ, et al. Preeclampsia and genetic factors for thrombosis: a case control study. Am J Obstet Gynecol 1999;181:975-980
26. Kupfermine MJ, Fait G, Many A, Girdon D, Eldor A, Lessing JB. Severe preeclampsia: high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000;96:45-49
27. Rigo J, Nagy B, Fintor L, Tanyi J, Beke A, Karadi I, Papp Z. Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutations and 5,10 methylenetetrahydrofolate reductase. Hypertens Pregnancy 2000;19:163-172
28. von Tempelhoff GF. Incidence of factor V Leiden mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP syndrome (hemolysis, elevated liver enzymes, low platelets). Thromb Res 2000;100:363-365
29. Kupferminc MJ, Peri H, Zwang E, Yaron Y, Wolman I, Eldor A. High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss. Acta Obstet Gynecol Scand 2000;79:963-967
30. Kim YJ, Williamson RA, Murray JC, et al. Genetic susceptibility to preeclampsia: roles of cytosine-to-thymine substitution at nucleotide 677 of the gene for methytetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathione [beta]-synthase, and factor V Leiden mutation. Am J Obstet Gynecol 2001;184:1211-1217
31. Livingston JC, Barton JR, Park V, Haddad B, Phillips O, Sibai BM. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001;185:153-157
32. Currie L, Peek M, McNiven M, Prosser I, Mansour J, Ridgway J. Is there an increased maternal-infant prevalence of factor V Leiden in association with severe pre-eclampsia? BJOG 2002;109:191-196
33. Benedetto C, Marozio L, Salton L, Maula V, Chieppa G, Massobrio M. Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. Acta Obstet Gynecol Scand 2002;81:1095-1100
34. Schlembach D, Beinder E, Zingsem J, Wunsiedler U, Beckmann MW, Fischer T. Association of maternal and/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction. Clin Sci 2003;105:279-285
35. Mello G, Parretti E, Marozio L, et al. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Hypertension 2005;46:1270-1274
36. Stanley-Christian H, Ghidini A, Sacher R, Shemirani M. Fetal genotype for specific inherited thrombophilias is not associated with severe preeclampsia. J Soc Gynecol Investig 2005;12:198-201
37. Prochaska M, Happach C, Marsal K, Dahlback B, Lindqvist PG. Factor V Leiden in pregnancies complicated by placental abruption. Br J Obstet Gynaecol 2003;110:462-466
38. Hira B, Pegoraro RJ, Rom L, Govender T, Moodley J. Polymorphisms in various coagulation genes in black South African women with placental abruption. BJOG 2002;109:574-575
39. Kupferminc MJ, Fait G, Many A, et al. Low molecular weight heparin for the prevention of obstetric complications in women with thrombophilias. Hypertens Pregnancy 2001;20:35-44
40. Infante-Rivard C, Rivard GE, Yotov WV, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med 2002;347:19-25
41. Verspyck E, Borg JY, Le Cam-Duchez V, et al. Thrombophilia and fetal growth restriction. Eur J Obstet Gynecol Reprod Biol 2004;113:36-40
42. McCowan LME, Craigie RM, Taylor RS, Ward C, McLintock C, North RA. Inherited thrombophilias are not increased in "idiopathic" small-for-gestational-age pregnancies. Am J Obstet Gynecol 2003;188:981-992
43. Kupfermine MJ, Many A, Bar-Am A, Lessing JB, Ascher-Landsberg J. Mid-trimester severe intrauterine growth restriction is associated with high prevalence of thrombophilia. BJOG 2002;109:1373-1376
44. Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol 2005;192:694-708
45. Martinelli I, Taioli E, Cetin I, et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000;343:1015-1018
46. Gonen R, Lavi N, Attias D, et al. Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death. Am J Obstet Gynecol 2005;192:742-746
47. Many A, Elad R, Yaron Y, Eldor A, Lessing J, Kupferminc MJ. Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 2002;99:684-687
48. Hefler L, Jirecek S, Heim K, et al. Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study. J Soc Gynecol Investig 2004;11:42-44
49. Sibai BM, El-Nazer A, Gonzalez-Ruiz A. Severe preeclampsia-eclampsia in young primagravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol 1986;155:1011-1016
50. Sibai BM, Mercer B, Sarinoglu C. Severe preeclampsia in the second trimester: recurrence risk and long-term prognosis. AmJ Obstet Gynecol 1991;165:1408-1412
51. Brenner B, Hoffman R, Blumenfeld Z, Weiner Z, Younis JS. Gestational outcome in thrombophilix women with recurrent pregnancy loss treated with enoxaparin. Thromb Haemost 2000;83:693-697
52. Ogueh O, Chen MF, Spurll G, Benjamin A. Outcome of pregnancy in women with hereditary thrombophilia. Int J Gynaecol Obstet 2001;74:247-253
53. Grandone E, Brancaccio V, Colaizzo D, et al. Preventing adverse obstetric outcomes in women with genetic thrombophilia. Fertil Steril 2002;78:371-375
54. Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996;174:1584-1589
55. Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipids antibodies (or antiphospholipid antibodies). BMJ 1997;314:253-257
56. Silver RK, MacGregor SN, Sholl JS, Hobart JM, Neerhof MG, Ragin A. Comparative trial of prednisone versus aspirin alone in the treatment of anticardiolipin antibody-positive obstetric patients. Am J Obstet Gynecol 1993;169:1411-1417
57. Pattison NS, Chamley LW, Birdsall M, Zanderigo AM, Liddell HS, McDougall J. Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial. Am J Obstet Gynecol 2000;183:1008-1012
58. Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002;100:408-413
59. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004;103:3695-3699
60. Branch DW, Khamashta MA. Antiphospholipid syndrome: obstetric diagnosis, management and controversies. Obstet Gynecol 2003;101:1333-1344
61. Rotmensch S, Liberati M, Mittleman M, Ben Rafael Z. Activated protein C resistance and adverse pregnancy outcome. Am J Obstet Gynecol 1997;177:170-173
62. Leeda M, Riyazi N, de Vries JI, Jakobs C, van Geijn HP, Dekker GA. Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia of fetal growth restriction. Am J Obstet Gynecol 1998;179:135-139