Metabolism of a heterocyclic amine colon carcinogen in young and old rats

Drug Metabolism and Disposition

Volumn 35, Issue 4, 2007, Pages 633-639

  Armbrecht, Harvey J ^a,b   Lakshmi, Vijaya M ^a,b   Wickstra, Jason ^a   Fong, Fu Hsu ^c   Zenser, Terry V ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; BETA NAPHTHOFLAVONE; CARCINOGEN; CYTOCHROME P450 1A1; GLUCURONIC ACID; HETEROCYCLIC AMINE; RADIOISOTOPE;

AGE DETERMINATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; URINALYSIS;

AGING; ANIMALS; BETA-NAPHTHOFLAVONE; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLONIC NEOPLASMS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GLUCURONIDES; INJECTIONS, INTRAPERITONEAL; INTESTINES; KIDNEY; LIVER; MALE; MOLECULAR STRUCTURE; QUINOLINES; RATS; RATS, INBRED F344; SULFURIC ACID ESTERS; TANDEM MASS SPECTROMETRY;

ANIMALIA; RATTUS;

EID: 34047152788     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013532     Document Type: Article

References (31)

1. Adamson RH, Thorgeirsson UP, Snyderwine EG, Thorgeirsson SS, Reeves J, Dalgard DW, Takayama S, and Sugimura T (1990) Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques. Jpn J Cancer Res 81:10-14.
2. Agrawal AK and Shapiro BH (2003) Constitutive and inducible hepatic cytochrome P450 isoforms in senescent male and female rats and response to low-dose phenobarbital. Drug Metab Dispos 31:612-619.
3. Armbrecht HJ, Boltz MA, and Kumar VB (1999) Intestinal plasma membrane calcium pump protein and its induction by 1,25(OH)(2)D(3) decrease with age. Am J Physiol 277:G41-G47.
4. Baylis C and Corman B (1998) The aging kidney: insights from experimental studies. J Am Soc Nephrol 9:699-709.
5. Boerrigter ME, Wei JY, and Vijg J (1995) Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity. Mech Ageing Dev 82:31-50.
6. Buonarati MH, Roper M, Morris CJ, Happe JA, Knize MG, and Felton JS (1992) Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice. Carcinogenesis 13:621-627.
7. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, and Willett WC (1994) Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Res 54:2390-2397.
8. Greenberg JA, Wei H, Ward K, and Boozer CN (2000) Whole-body metabolic rate appears to determine the rate of DNA oxidative damage and glycation involved in aging. Mech Ageing Dev 115:107-117.
9. Hamilton ML, Van RH, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, and Richardson A (2001) Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA 98:10469-10474.
10. Horbach GJ, van Asten JG, Rietjens IM, Kremers P, and van Bezooijen CF (1992) The effect of age on inducibility of various types of rat liver cytochrome P-450. Xenobiotica 22:515-522.
11. Horbach GJ, van Asten JG, and van Bezooijen CF (1990a) The influence of ageing on the induction of the mRNAs of rat liver cytochromes P450IIB1 and P450IIB2. Biochem Pharmacol 40:529-533.
12. Horbach GJ, Venkataraman JT, and Fernandes G (1990b) Food restriction prevents the loss of isosafrole inducible cytochrome P-450 mRNA and enzyme levels in aging rats. Biochem Int 20:725-730.
13. Inamasu T, Luks H, Vavrek MT, and Weisburger JH (1989) Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline in the male rat. Food Chem Toxicol 27:369-376.
14. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, and Thun MJ (2005) Cancer statistics, 2005. CA Cancer J Clin 55:10-30.
15. Kristiansen E, Meyer O, and Thorup I (1997) The ability of two cooked food mutagens to induce aberrant crypt foci in mice. Eur J Cancer Prev 6:53-57.
16. Liu RM and Dickinson DA (2003) Decreased synthetic capacity underlies the age-associated decline in glutathione content in Fisher 344 rats. Antioxid Redox Signal 5:529-536.
17. Luks HJ, Spratt TE, Vavrek MT, Roland SF, and Weisburger JH (1989) Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats. Cancer Res 49:4407-4411.
18. Lynch AM, Knize MG, Boobis AR, Gooderham NJ, Davies DS, and Murray S (1992) Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[ 4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res 52:6216-6223.
19. McManus ME, Burgess WM, Veronese ME, Huggett A, Quattrochi LC, and Tukey RH (1990) Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res 50:3367-3376.
20. [NTP] National Toxicology Program (2005) Report on carcinogens background document for heterocyclic amines: MeIQ, MeIQx, IQ, and PhIP. National Toxicology Program. http://ntp niehs nih gov/ntp/roc/eleventh/profiles/ s092vhca pdf.
21. Pais P, Salmon CP, Knize MG, and Felton JS (1999) Formation of mutagenic/carcinogenic heterocyclic amines in dry-heated model systems, meats, and meat drippings. J Agric Food Chem 47:1098-1108.
22. Pegram RA, Diliberto JJ, Moore TC, Gao P, and Birnbaum LS (1995) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) distribution and cytochrome P4501A induction in young adult and senescent male mice. Toxicol Lett 76:119-126.
23. Sugimura T (2000) Nutrition and dietary carcinogens. Carcinogenesis 21:387-395.
24. Takayama S, Nakatsuru Y, Masuda M, Ohgaki H, Sato S, and Sugimura T (1984) Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl- imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract. Gann 75:467-470.
25. Tanaka T, Barnes WS, Williams GM, and Weisburger JH (1985) Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f] quinoline in rats. Jpn J Cancer Res 76:570-576.
26. Tarry-Adkins JL, Ozanne SE, Norden A, Cherif H, and Hales CN (2006) Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity. Am J Physiol 290:F509-F516.
27. Teillet L, Verbeke P, Gouraud S, Bakala H, Borot-Laloi C, Heudes D, Bruneval P, and Corman B (2000) Food restriction prevents advanced glycation end product accumulation and retards kidney aging in lean rats. J Am Soc Nephrol 11:1488-1497.
28. Tian L, Cai Q, and Wei H (1998) Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic Biol Med 24:1477-1484.
29. Turesky RJ, Constable A, Richoz J, Varga N, Markovic J, Martin MV, and Guengerich FP (1998) Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chem Res Toxicol 11:925-936.
30. Turesky RJ and Markovic J (1995) DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in liver, kidney and colo-rectum of rats. Carcinogenesis 16:2275-2279.
31. Turesky RJ, Skipper PL, Tannenbaum SR, Coles B, and Ketterer B (1986) Sulfamate formation is a major route for detoxification of 2-amino-3- methylimidazo[4,5-f]quinoline in the rat. Carcinogenesis 7:1483-1485.