STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line

Biochemical and Biophysical Research Communications

Volumn 356, Issue 3, 2007, Pages 727-732

  Rodriguez Granillo, Agustina ^a   Boffi, Juan Carlos ^a   Barañao, Lino ^a,b   Kordon, Edith ^b   Pecci, Adali ^a,b   Guberman, Alejandra ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b CONICET ^*  (Argentina)

Author keywords

Gene expression; HC11; Involution; LIF; Mammary epithelium; Prolactin; Signal transduction; STAT3; STAT5

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; PROLACTIN; STAT3 PROTEIN; STAT5 PROTEIN;

ARTICLE; BREAST EPITHELIUM; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; INVOLUTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BCL-X PROTEIN; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; DEXAMETHASONE; EPITHELIUM; INSULIN; LEUKEMIA INHIBITORY FACTOR; MAMMARY GLANDS, ANIMAL; MICE; PHOSPHORYLATION; PROLACTIN; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 34047144569     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.03.040     Document Type: Article

References (28)

1. O'Shea J.J., Gadina M., and Schreiber R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109 Suppl. (2002) S121-S131
2. Schindler C., and Strehlow I. Cytokines and STAT signaling. Adv. Pharmacol. 47 (2000) 113-174
3. Pranada A.L., Metz S., Herrmann A., Heinrich P.C., and Muller-Newen G. Real time analysis of STAT3 nucleocytoplasmic shuttling. J. Biol. Chem. 279 (2004) 15114-15123
4. Zeng R., Aoki Y., Yoshida M., Arai K., and Watanabe S. Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. J. Immunol. 168 (2002) 4567-4575
5. Meyer T., Hendry L., Begitt A., John S., and Vinkemeier U. A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J. Biol. Chem. 279 (2004) 18998-19007
6. Aaronson D.S., and Horvath C.M. A road map for those who don't know JAK-STAT. Science 296 (2002) 1653-1655
7. Levy D.E., and Darnell Jr. J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3 (2002) 651-662
8. Darnell Jr. J.E. Phosphotyrosine signaling and the single cell:metazoan boundary. Proc. Natl. Acad. Sci. USA 94 (1997) 11767-11769
9. Groner B., and Hennighausen L. Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium. Breast Cancer Res. 2 (2000) 149-153
10. Teglund S., McKay C., Schuetz E., van Deursen J.M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., and Ihle J.N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93 (1998) 841-850
11. Clarkson R.W., Boland M.P., Kritikou E.A., Lee J.M., Freeman T.C., Tiffen P.G., and Watson C.J. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol. Endocrinol. 20 (2006) 675-685
12. Watson C.J. Stat transcription factors in mammary gland development and tumorigenesis. J. Mammary Gland Biol. Neoplasia 6 (2001) 115-127
13. Wartmann M., Cella N., Hofer P., Groner B., Liu X., Hennighausen L., and Hynes N.E. Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity. J. Biol. Chem. 271 (1996) 31863-31868
14. Pecci A., Viegas L.R., Baranao J.L., and Beato M. Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-X gene. J. Biol. Chem. 276 (2001) 21062-21069
15. Ariyoshi K., Nosaka T., Yamada K., Onishi M., Oka Y., Miyajima A., and Kitamura T. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275 (2000) 24407-24413
16. Guberman A.S., Scassa M.E., Giono L.E., Varone C.L., and Canepa E.T. Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator. J. Biol. Chem. 278 (2003) 2317-2326
17. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
18. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
19. Liu X., Robinson G.W., and Hennighausen L. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol. 10 (1996) 1496-1506
20. Philp J.A., Burdon T.G., and Watson C.J. Differential activation of STATs 3 and 5 during mammary gland development. FEBS Lett. 396 (1996) 77-80
21. Mitchell T.J., and John S. Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas. Immunology 114 (2005) 301-312
22. Groner B. Transcription factor regulation in mammary epithelial cells. Domest. Anim. Endocrinol. 23 (2002) 25-32
23. Socolovsky M., Fallon A.E., Wang S., Brugnara C., and Lodish H.F. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98 (1999) 181-191
24. Ke Y., Lesperance J., Zhang E.E., Bard-Chapeau E.A., Oshima R.G., Muller W.J., and Feng G.S. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J. Biol. Chem. 281 (2006) 34374-34380
25. Boudreau F., Zannoni S., Pelletier N., Bardati T., Yu S.J., and Asselin C. Negative regulation of glucocorticoid-dependent induction of c-fos by ras in intestinal epithelial cells. Mol. Cell Biochem. 195 (1999) 99-111
26. Sato Y., Nishio Y., Sekine O., Kodama K., Nagai Y., Nakamura T., Maegawa H., and Kashiwagi A. Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats. Diabetologia 50 (2007) 481-489
27. Cella N., Chiquet-Ehrismann R., and Hynes N.E. Lactogenic hormones and tenascin-C regulate C/EBPalpha and beta in mammary epithelial cells. J. Cell Biochem. 76 (2000) 394-403
28. Jones C.S., and Parker D.S. Prolactin receptors in the lactating rabbit mammary gland during initiated involution. Int. J. Biochem. 15 (1983) 1389-1391