Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes

Chemico-Biological Interactions

Volumn 167, Issue 3, 2007, Pages 184-192

  Sadeghi Aliabadi, Hojjat ^a   Chan, Katie ^c   Lehmler, Hans Joachim ^b   Robertson, Larry W ^b   O'Brien, Peter J ^c  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

4 Chlorobiphenyl; Catechols; Cytotoxicity; Dihyroxylated metabolites; Glutathione; Hepatocytes; Oxidative stress; PCBs; Polychlorinated biphenyls

Indexed keywords

BENZOQUINONE; BORNEOL; CATECHOL METHYLTRANSFERASE INHIBITOR; CHLORINE; ENTACAPONE; GLYCOSYLTRANSFERASE INHIBITOR; HYDROXYL GROUP; POLYCHLORINATED BIPHENYL DERIVATIVE; SEMIQUINONE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; COMPARATIVE STUDY; CONJUGATION; CORRELATION ANALYSIS; CYTOTOXICITY; GLUCURONIDATION; LC 50; LIVER CELL; LIVER TOXICITY; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; TOXICOLOGY;

ACUTE TOXICITY TESTS; ANIMALS; BIPHENYL COMPOUNDS; BORNANES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; GLUCURONOSYLTRANSFERASE; GLUTATHIONE; HEPATOCYTES; MALE; MOLECULAR STRUCTURE; NITRILES; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 34047139426     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.02.011     Document Type: Article

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