Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions

Virology

Volumn 360, Issue 2, 2007, Pages 247-256

  Xu, Hongzhan ^a   Chertova, Elena ^b   Chen, Jianbo ^a   Ott, David E ^b   Roser, James D ^b   Hu, Wei Shau ^a   Pathak, Vinay K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

vif virions; APOBEC3G virion incorporation; Cytidine deamination; Peripheral mononuclear blood cells; Scintillation proximity assay

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; CAPSID PROTEIN; GAG PROTEIN; VIF PROTEIN;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; MOLECULE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCINTILLATION; SCINTILLATION PROXIMITY ASSAY; STOICHIOMETRY; VIRION; VIRUS REPLICATION;

CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE DELETION; GENE PRODUCTS, GAG; GENE PRODUCTS, VIF; HIV-1; HUMANS; IMMUNOBLOTTING; LEUKOCYTES, MONONUCLEAR; NUCLEOSIDE DEAMINASES; REPRESSOR PROTEINS; SCINTILLATION COUNTING; VIRION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

EID: 33947732622     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.10.036     Document Type: Article

References (44)

1. Alce T.M., and Popik W. APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein. J. Biol. Chem. 279 33 (2004) 34083-34086
2. Bess Jr. J.W., Gorelick R.J., Bosche W.J., Henderson L.E., and Arthur L.O. Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations. Virology 230 1 (1997) 134-144
3. Bishop K.N., Holmes R.K., Sheehy A.M., Davidson N.O., Cho S.J., and Malim M.H. Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr. Biol. 14 15 (2004) 1392-1396
4. Bishop K.N., Holmes R.K., and Malim M.H. Antiviral potency of APOBEC proteins does not correlate with cytidine deamination. J. Virol. 80 17 (2006) 8450-8458
5. Borman A.M., Quillent C., Charneau P., Dauguet C., and Clavel F. Human immunodeficiency virus type 1 Vif-mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity. J. Virol. 69 4 (1995) 2058-2067
6. Briggs J.A., Simon M.N., Gross I., Krausslich H.G., Fuller S.D., Vogt V.M., and Johnson M.C. The stoichiometry of Gag protein in HIV-1. Nat. Struct. Mol. Biol. 11 7 (2004) 672-675
7. Cen S., Guo F., Niu M., Saadatmand J., Deflassieux J., and Kleiman L. The interaction between HIV-1 Gag and APOBEC3G. J. Biol. Chem. 279 32 (2004) 33177-33184
8. Chen J.J., Huang J.C., Shirtliff M., Briscoe E., Ali S., Cesani F., Paar D., and Cloyd M.W. CD4 lymphocytes in the blood of HIV(+) individuals migrate rapidly to lymph nodes and bone marrow: support for homing theory of CD4 cell depletion. J. Leukocyte Biol. 72 2 (2002) 271-278
9. Conticello S.G., Harris R.S., and Neuberger M.S. The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Curr. Biol. 13 22 (2003) 2009-2013
10. Gaddis N.C., Chertova E., Sheehy A.M., Henderson L.E., and Malim M.H. Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. J. Virol. 77 10 (2003) 5810-5820
11. Gluschankof P., Mondor I., Gelderblom H.R., and Sattentau Q.J. Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations. Virology 230 1 (1997) 125-133
12. Harris R.S., and Liddament M.T. Retroviral restriction by APOBEC proteins. Nat. Rev., Immunol. 4 11 (2004) 868-877
13. Harris R.S., Bishop K.N., Sheehy A.M., Craig H.M., Petersen-Mahrt S.K., Watt I.N., Neuberger M.S., and Malim M.H. DNA deamination mediates innate immunity to retroviral infection. Cell 113 6 (2003) 803-809
14. Kao S., Khan M.A., Miyagi E., Plishka R., Buckler-White A., and Strebel K. The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15) a cellular inhibitor of virus infectivity. J. Virol. 77 21 (2003) 11398-11407
15. Klarmann G.J., Chen X., North T.W., and Preston B.D. Incorporation of uracil into minus strand DNA affects the specificity of plus strand synthesis initiation during lentiviral reverse transcription. J. Biol. Chem. 278 10 (2003) 7902-7909
16. Layne S.P., Merges M.J., Dembo M., Spouge J.L., Conley S.R., Moore J.P., Raina J.L., Renz H., Gelderblom H.R., and Nara P.L. Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus. Virology 189 2 (1992) 695-714
17. Lecossier D., Bouchonnet F., Clavel F., and Hance A.J. Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science 300 5622 (2003) 1112
18. Liddament M.T., Brown W.L., Schumacher A.J., and Harris R.S. APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Curr. Biol. 14 15 (2004) 1385-1391
19. Luo K., Liu B., Xiao Z., Yu Y., Yu X., Gorelick R., and Yu X.F. Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging. J. Virol. 78 21 (2004) 11841-11852
20. Madani N., and Kabat D. An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. J. Virol. 72 12 (1998) 10251-10255
21. Mangeat B., Turelli P., Caron G., Friedli M., Perrin L., and Trono D. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 424 6944 (2003) 99-103
22. Mariani R., Chen D., Schrofelbauer B., Navarro F., Konig R., Bollman B., Munk C., Nymark-McMahon H., and Landau N.R. Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 114 1 (2003) 21-31
23. Marin M., Rose K.M., Kozak S.L., and Kabat D. HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nat. Med. 9 11 (2003) 1398-1403
24. Newman E.N., Holmes R.K., Craig H.M., Klein K.C., Lingappa J.R., Malim M.H., and Sheehy A.M. Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity. Curr. Biol. 15 2 (2005) 166-170
25. Ott D.E., Coren L.V., Johnson D.G., Sowder II R.C., Arthur L.O., and Henderson L.E. Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain. AIDS Res. Hum. Retroviruses 11 9 (1995) 1003-1006
26. Ott D.E., Coren L.V., Johnson D.G., Kane B.P., Sowder II R.C., Kim Y.D., Fisher R.J., Zhou X.Z., Lu K.P., and Henderson L.E. Actin-binding cellular proteins inside human immunodeficiency virus type 1. Virology 266 1 (2000) 42-51
27. Pathak V.K., and Temin H.M. Broad spectrum of in vivo forward mutations, hypermutations, mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions. Proc. Natl. Acad. Sci. U.S.A. 87 16 (1990) 6024-6028
28. Poon D.T., Chertova E.N., and Ott D.E. Human immunodeficiency virus type 1 preferentially encapsidates genomic RNAs that encode Pr55(Gag): functional linkage between translation and RNA packaging. Virology 293 2 (2002) 368-378
29. Sambrook J., and Russell D.W. Mol. Cloning: Lab. Man. 3rd Edition vols. 3.3 (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
30. Schafer A., Bogerd H.P., and Cullen B.R. Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor. Virology 328 2 (2004) 163-168
31. Sheehy A.M., Gaddis N.C., Choi J.D., and Malim M.H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418 6898 (2002) 646-650
32. Simon J.H., Gaddis N.C., Fouchier R.A., and Malim M.H. Evidence for a newly discovered cellular anti-HIV-1 phenotype. Nat. Med. 4 12 (1998) 1397-1400
33. Stopak K., de Noronha C., Yonemoto W., and Greene W.C. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol. Cell 12 3 (2003) 591-601
34. Svarovskaia E.S., Xu H., Mbisa J.L., Barr R., Gorelick R.J., Ono A., Freed E.O., Hu W.S., and Pathak V.K. Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. J. Biol. Chem. 279 34 (2004) 35822-35828
35. Trubey C.M., Chertova E., Coren L.V., Hilburn J.M., Hixson C.V., Nagashima K., Lifson J.D., and Ott D.E. Quantitation of HLA class II protein incorporated into human immunodeficiency type 1 virions purified by anti-CD45 immunoaffinity depletion of microvesicles. J. Virol. 77 23 (2003) 12609-12699
36. Unutmaz D., KewalRamani V.N., Marmon S., and Littman D.R. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189 11 (1999) 1735-1746
37. Vartanian J.P., Meyerhans A., Asjo B., and Wain-Hobson S. Selection, recombination, G-A hypermutation of human immunodeficiency virus type 1 genomes. J. Virol. 65 4 (1991) 1779-1788
38. von Schwedler U., Song J., Aiken C., and Trono D. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol. 67 8 (1993) 4945-4955
39. Yee J.K., Friedmann T., and Burns J.C. Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods Cell Biol. 43 Pt. A (1994) 99-112
40. Yu X., Yu Y., Liu B., Luo K., Kong W., Mao P., and Yu X.F. Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. Science 302 5647 (2003) 1056-1060
41. Zennou V., Perez-Caballero D., Gottlinger H., and Bieniasz P.D. APOBEC3G incorporation into human immunodeficiency virus type 1 particles. J. Virol. 78 21 (2004) 12058-12061
42. Zhang H., Yang B., Pomerantz R.J., Zhang C., Arunachalam S.C., and Gao L. The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature 424 6944 (2003) 94-98
43. Zheng Y.H., Irwin D., Kurosu T., Tokunaga K., Sata T., and Peterlin B.M. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. J. Virol. 78 11 (2004) 6073-6076
44. Zhu P., Chertova E., Bess Jr. J., Lifson J.D., Arthur L.O., Liu J., Taylor K.A., and Roux K.H. Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc. Natl. Acad. Sci. U.S.A. 100 26 (2003) 15812-15817