Prediction of binding affinities to β1 isoform of human thyroid hormone receptor by genetic algorithm and projection pursuit regression

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2474-2482

  Ren, Yueying ^a   Liu, Huanxiang ^a   Li, Shuyan ^a   Yao, Xiaojun ^a,b   Liu, Mancang ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

1 Isoform of human thyroid hormone receptor; Genetic algorithm; Principle component analysis; Projection pursuit regression; QSAR

Indexed keywords

ANTITHYROID AGENT; THYROID HORMONE RECEPTOR BETA; THYROID HORMONE RECEPTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; DRUG SAFETY; GENETIC ALGORITHM; HYDROPHOBICITY; IC 50; MOLECULAR SIZE; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, STATISTICAL; PHARMACOGENETICS; PROTEIN BINDING; PROTEIN ISOFORMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, THYROID HORMONE; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SOFTWARE;

EID: 33947726051     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.025     Document Type: Article

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