-
1
-
-
0033975651
-
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis
-
Asamoto M., Ochiya T., Toriyama-Baba H., Ota T., Sekiya T., Terada M., and Tsuda H. Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis. Carcinogenesis 21 (2000) 243-249
-
(2000)
Carcinogenesis
, vol.21
, pp. 243-249
-
-
Asamoto, M.1
Ochiya, T.2
Toriyama-Baba, H.3
Ota, T.4
Sekiya, T.5
Terada, M.6
Tsuda, H.7
-
2
-
-
0020326790
-
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
-
Castagna M., Takai Y., Kaibuchi K., Sano K., Kikkawa U., and Nishizuka Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257 (1982) 7847-7851
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 7847-7851
-
-
Castagna, M.1
Takai, Y.2
Kaibuchi, K.3
Sano, K.4
Kikkawa, U.5
Nishizuka, Y.6
-
3
-
-
28844470325
-
A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats
-
Chengelis C.P., Kirkpatrick J.B., Bruner R.H., Freshwater L., Morita O., Tamaki Y., and Suzuki H. A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats. Food Chem. Toxicol. 44 (2006) 98-121
-
(2006)
Food Chem. Toxicol.
, vol.44
, pp. 98-121
-
-
Chengelis, C.P.1
Kirkpatrick, J.B.2
Bruner, R.H.3
Freshwater, L.4
Morita, O.5
Tamaki, Y.6
Suzuki, H.7
-
4
-
-
28844444590
-
A 24-month dietary carcinogenicity study of DAG in mice
-
Chengelis C.P., Kirkpatrick J.B., Bruner R.H., Freshwater L., Morita O., Tamaki Y., and Suzuki H. A 24-month dietary carcinogenicity study of DAG in mice. Food Chem. Toxicol. 44 (2006) 122-137
-
(2006)
Food Chem. Toxicol.
, vol.44
, pp. 122-137
-
-
Chengelis, C.P.1
Kirkpatrick, J.B.2
Bruner, R.H.3
Freshwater, L.4
Morita, O.5
Tamaki, Y.6
Suzuki, H.7
-
5
-
-
28844441275
-
A chronic dietary toxicity study of DAG (diacylglycerol) in Beagle dogs
-
Chengelis C.P., Kirkpatrick J.B., Marit G.B., Morita O., Tamaki Y., and Suzuki H. A chronic dietary toxicity study of DAG (diacylglycerol) in Beagle dogs. Food Chem. Toxicol. 44 (2006) 81-97
-
(2006)
Food Chem. Toxicol.
, vol.44
, pp. 81-97
-
-
Chengelis, C.P.1
Kirkpatrick, J.B.2
Marit, G.B.3
Morita, O.4
Tamaki, Y.5
Suzuki, H.6
-
6
-
-
0026620419
-
Protein kinase C is activated and diacylglycerol is elevated in epidermal cells from Sencar mice fed high fat diets
-
Choe M., Kris E.S., Luthra R., Copenhaver J., Pelling J.C., Donnelly T.E., and Birt D.F. Protein kinase C is activated and diacylglycerol is elevated in epidermal cells from Sencar mice fed high fat diets. J. Nutr. 122 (1992) 2322-2329
-
(1992)
J. Nutr.
, vol.122
, pp. 2322-2329
-
-
Choe, M.1
Kris, E.S.2
Luthra, R.3
Copenhaver, J.4
Pelling, J.C.5
Donnelly, T.E.6
Birt, D.F.7
-
7
-
-
0033991148
-
Ras gene mutations in oral cancer in eastern India
-
Das N., Majumder J., and DasGupta U.B. Ras gene mutations in oral cancer in eastern India. Oral Oncol. 36 (2000) 76-80
-
(2000)
Oral Oncol.
, vol.36
, pp. 76-80
-
-
Das, N.1
Majumder, J.2
DasGupta, U.B.3
-
8
-
-
0024545288
-
Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells
-
Friedman E., Isaksson P., Rafter J., Marian B., Winawer S., and Newmark H. Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells. Cancer Res. 49 (1989) 544-548
-
(1989)
Cancer Res.
, vol.49
, pp. 544-548
-
-
Friedman, E.1
Isaksson, P.2
Rafter, J.3
Marian, B.4
Winawer, S.5
Newmark, H.6
-
9
-
-
0035983760
-
Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats
-
Han B.S., Fukamachi K., Takasuka N., Ohnishi T., Maeda M., Yamasaki T., and Tsuda H. Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Carcinogenesis 23 (2002) 1209-1215
-
(2002)
Carcinogenesis
, vol.23
, pp. 1209-1215
-
-
Han, B.S.1
Fukamachi, K.2
Takasuka, N.3
Ohnishi, T.4
Maeda, M.5
Yamasaki, T.6
Tsuda, H.7
-
10
-
-
0031050299
-
Taxonomy and function of C1 protein kinase C homology domains
-
Hurley J.H., Newton A.C., Parker P.J., Blumberg P.M., and Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Sci. 6 (1997) 477-480
-
(1997)
Protein Sci.
, vol.6
, pp. 477-480
-
-
Hurley, J.H.1
Newton, A.C.2
Parker, P.J.3
Blumberg, P.M.4
Nishizuka, Y.5
-
11
-
-
11044239131
-
Genotoxicity studies on dietary diacylglycerol (DAG) oil
-
Kasamatsu T., Ogura R., Ikeda N., Morita O., Saigo K., Watabe H., Saito Y., and Suzuki H. Genotoxicity studies on dietary diacylglycerol (DAG) oil. Food Chem. Toxicol. 43 (2005) 253-260
-
(2005)
Food Chem. Toxicol.
, vol.43
, pp. 253-260
-
-
Kasamatsu, T.1
Ogura, R.2
Ikeda, N.3
Morita, O.4
Saigo, K.5
Watabe, H.6
Saito, Y.7
Suzuki, H.8
-
12
-
-
0036209077
-
Novel "nonkinase" phorbol ester receptors: the C1 domain connection
-
Kazanietz M.G. Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol. Pharmacol. 61 (2002) 759-767
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 759-767
-
-
Kazanietz, M.G.1
-
13
-
-
0028265959
-
Lipid second messengers
-
Liscovitch M., and Cantley L.C. Lipid second messengers. Cell 77 (1994) 329-334
-
(1994)
Cell
, vol.77
, pp. 329-334
-
-
Liscovitch, M.1
Cantley, L.C.2
-
14
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters
-
Lorenzo P.S., Beheshti M., Pettit G.R., Stone J.C., and Blumberg P.M. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters. Mol. Pharmacol. 57 (2000) 840-846
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 840-846
-
-
Lorenzo, P.S.1
Beheshti, M.2
Pettit, G.R.3
Stone, J.C.4
Blumberg, P.M.5
-
15
-
-
0032478610
-
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
-
Marais R., Light Y., Mason C., Paterson H., Olson M.F., and Marshall C.J. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280 (1998) 109-112
-
(1998)
Science
, vol.280
, pp. 109-112
-
-
Marais, R.1
Light, Y.2
Mason, C.3
Paterson, H.4
Olson, M.F.5
Marshall, C.J.6
-
16
-
-
1542273633
-
Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue
-
Meng X., Zou D., Shi Z., Duan Z., and Mao Z. Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue. Lipids 39 (2004) 37-41
-
(2004)
Lipids
, vol.39
, pp. 37-41
-
-
Meng, X.1
Zou, D.2
Shi, Z.3
Duan, Z.4
Mao, Z.5
-
17
-
-
0026750297
-
Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol
-
Mills K.J., Bocckino S.B., Burns D.J., Loomis C.R., and Smart R.C. Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol. Carcinogenesis 13 (1992) 1113-1120
-
(1992)
Carcinogenesis
, vol.13
, pp. 1113-1120
-
-
Mills, K.J.1
Bocckino, S.B.2
Burns, D.J.3
Loomis, C.R.4
Smart, R.C.5
-
18
-
-
0027742472
-
Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes
-
Mills K.J., Reynolds S.H., and Smart R.C. Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes. Carcinogenesis 14 (1993) 2645-2648
-
(1993)
Carcinogenesis
, vol.14
, pp. 2645-2648
-
-
Mills, K.J.1
Reynolds, S.H.2
Smart, R.C.3
-
19
-
-
0031656674
-
Overexpression of the ERK/MAP kinases in oral squamous cell carcinoma
-
Mishima K., Yamada E., Masui K., Shimokawara T., Takayama K., Sugimura M., and Ichijima K. Overexpression of the ERK/MAP kinases in oral squamous cell carcinoma. Mod. Pathol. 11 (1998) 886-891
-
(1998)
Mod. Pathol.
, vol.11
, pp. 886-891
-
-
Mishima, K.1
Yamada, E.2
Masui, K.3
Shimokawara, T.4
Takayama, K.5
Sugimura, M.6
Ichijima, K.7
-
20
-
-
0021227676
-
The role of protein kinase C in cell surface signal transduction and tumour promotion
-
Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308 (1984) 693-698
-
(1984)
Nature
, vol.308
, pp. 693-698
-
-
Nishizuka, Y.1
-
21
-
-
18244392935
-
Metabolites of dietary triacylglycerol and diacylglycerol during the digestion process in rats
-
Osaki N., Meguro S., Yajima N., Matsuo N., Tokimitsu I., and Shimasaki H. Metabolites of dietary triacylglycerol and diacylglycerol during the digestion process in rats. Lipids 40 (2005) 281-286
-
(2005)
Lipids
, vol.40
, pp. 281-286
-
-
Osaki, N.1
Meguro, S.2
Yajima, N.3
Matsuo, N.4
Tokimitsu, I.5
Shimasaki, H.6
-
22
-
-
1842845052
-
Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate
-
Park C.B., Fukamachi K., Takasuka N., Han B.S., Kim C.K., Hamaguchi T., Fujita K., Ueda S., and Tsuda H. Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate. Cancer Sci. 95 (2004) 205-210
-
(2004)
Cancer Sci.
, vol.95
, pp. 205-210
-
-
Park, C.B.1
Fukamachi, K.2
Takasuka, N.3
Han, B.S.4
Kim, C.K.5
Hamaguchi, T.6
Fujita, K.7
Ueda, S.8
Tsuda, H.9
-
23
-
-
0029057644
-
Dietary fat, fiber, and carcinogen alter fecal diacylglycerol composition and mass
-
Pickering J.S., Lupton J.R., and Chapkin R.S. Dietary fat, fiber, and carcinogen alter fecal diacylglycerol composition and mass. Cancer Res. 55 (1995) 2293-2298
-
(1995)
Cancer Res.
, vol.55
, pp. 2293-2298
-
-
Pickering, J.S.1
Lupton, J.R.2
Chapkin, R.S.3
-
24
-
-
0033951214
-
Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion
-
Reddig P.J., Dreckschmidt N.E., Zou J., Bourguignon S.E., Oberley T.D., and Verma A.K. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. Cancer Res. 60 (2000) 595-602
-
(2000)
Cancer Res.
, vol.60
, pp. 595-602
-
-
Reddig, P.J.1
Dreckschmidt, N.E.2
Zou, J.3
Bourguignon, S.E.4
Oberley, T.D.5
Verma, A.K.6
-
25
-
-
0029994786
-
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion
-
Reddy B.S., Simi B., Patel N., Aliaga C., and Rao C.V. Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion. Cancer Res. 56 (1996) 2314-2320
-
(1996)
Cancer Res.
, vol.56
, pp. 2314-2320
-
-
Reddy, B.S.1
Simi, B.2
Patel, N.3
Aliaga, C.4
Rao, C.V.5
-
26
-
-
18944383647
-
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells
-
Roose J.P., Mollenauer M., Gupta V.A., Stone J., and Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol. Cell Biol. 25 (2005) 4426-4441
-
(2005)
Mol. Cell Biol.
, vol.25
, pp. 4426-4441
-
-
Roose, J.P.1
Mollenauer, M.2
Gupta, V.A.3
Stone, J.4
Weiss, A.5
-
27
-
-
0033842054
-
Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications
-
Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications. Oral Oncol. 36 (2000) 404-413
-
(2000)
Oral Oncol.
, vol.36
, pp. 404-413
-
-
Scully, C.1
Field, J.K.2
Tanzawa, H.3
-
29
-
-
0026453081
-
Activation of the c-Raf protein kinase by protein kinase C phosphorylation
-
Sozeri O., Vollmer K., Liyanage M., Frith D., Kour G., Mark III G.E., and Stabel S. Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene 7 (1992) 2259-2262
-
(1992)
Oncogene
, vol.7
, pp. 2259-2262
-
-
Sozeri, O.1
Vollmer, K.2
Liyanage, M.3
Frith, D.4
Kour, G.5
Mark III, G.E.6
Stabel, S.7
-
30
-
-
14844292363
-
Dimethylbenz(a)anthracene-induced mammary tumorigenesis in Sprague-Dawley rats fed saturated and polyunsaturated triacylglycerols and diacylglycerols
-
Sugano M., Akahoshi A., Nishida E., Shibata A., and Ohkawa Y. Dimethylbenz(a)anthracene-induced mammary tumorigenesis in Sprague-Dawley rats fed saturated and polyunsaturated triacylglycerols and diacylglycerols. J. Oleo. Sci. 51 (2002) 583-588
-
(2002)
J. Oleo. Sci.
, vol.51
, pp. 583-588
-
-
Sugano, M.1
Akahoshi, A.2
Nishida, E.3
Shibata, A.4
Ohkawa, Y.5
-
31
-
-
0038125607
-
Dietary diacylglycerol-rich oil stimulation of glucose intolerance in genetically obese rats
-
Sugimoto T., Fukuda H., Kimura T., and Iritani N. Dietary diacylglycerol-rich oil stimulation of glucose intolerance in genetically obese rats. J. Nutr. Sci. Vitaminol. (Tokyo) 49 (2003) 139-144
-
(2003)
J. Nutr. Sci. Vitaminol. (Tokyo)
, vol.49
, pp. 139-144
-
-
Sugimoto, T.1
Fukuda, H.2
Kimura, T.3
Iritani, N.4
-
32
-
-
0038662792
-
Comparisons of glucose and lipid metabolism in rats fed diacylglycerol and triacylglycerol oils
-
Sugimoto T., Kimura T., Fukuda H., and Iritani N. Comparisons of glucose and lipid metabolism in rats fed diacylglycerol and triacylglycerol oils. J. Nutr. Sci. Vitaminol. (Tokyo) 49 (2003) 47-55
-
(2003)
J. Nutr. Sci. Vitaminol. (Tokyo)
, vol.49
, pp. 47-55
-
-
Sugimoto, T.1
Kimura, T.2
Fukuda, H.3
Iritani, N.4
-
33
-
-
0029549836
-
Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions
-
Suzui M., Yoshimi N., Tanaka T., and Mori H. Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions. Mol. Carcinog. 14 (1995) 294-298
-
(1995)
Mol. Carcinog.
, vol.14
, pp. 294-298
-
-
Suzui, M.1
Yoshimi, N.2
Tanaka, T.3
Mori, H.4
-
34
-
-
33644849048
-
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
-
Suzuki R., Kohno H., Suzui M., Yoshimi N., Tsuda H., Wakabayashi K., and Tanaka T. An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis 27 (2006) 619-630
-
(2006)
Carcinogenesis
, vol.27
, pp. 619-630
-
-
Suzuki, R.1
Kohno, H.2
Suzui, M.3
Yoshimi, N.4
Tsuda, H.5
Wakabayashi, K.6
Tanaka, T.7
-
35
-
-
1642453724
-
Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
-
Tang X.H., Knudsen B., Bemis D., Tickoo S., and Gudas L.J. Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice. Clin. Cancer Res. 10 (2004) 301-313
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 301-313
-
-
Tang, X.H.1
Knudsen, B.2
Bemis, D.3
Tickoo, S.4
Gudas, L.J.5
-
36
-
-
22444434833
-
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model
-
Tsuda H., Fukamachi K., Ohshima Y., Ueda S., Matsuoka Y., Hamaguchi T., Ohnishi T., Takasuka N., and Naito A. High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model. Cancer Sci. 96 (2005) 309-316
-
(2005)
Cancer Sci.
, vol.96
, pp. 309-316
-
-
Tsuda, H.1
Fukamachi, K.2
Ohshima, Y.3
Ueda, S.4
Matsuoka, Y.5
Hamaguchi, T.6
Ohnishi, T.7
Takasuka, N.8
Naito, A.9
-
37
-
-
4644280263
-
Microbial species involved in production of 1,2-sn-diacylglycerol and effects of phosphatidylcholine on human fecal microbiota
-
Vulevic J., McCartney A.L., Gee J.M., Johnson I.T., and Gibson G.R. Microbial species involved in production of 1,2-sn-diacylglycerol and effects of phosphatidylcholine on human fecal microbiota. Appl. Environ. Microbiol. 70 (2004) 5659-5666
-
(2004)
Appl. Environ. Microbiol.
, vol.70
, pp. 5659-5666
-
-
Vulevic, J.1
McCartney, A.L.2
Gee, J.M.3
Johnson, I.T.4
Gibson, G.R.5
-
38
-
-
0032527674
-
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use
-
Xu J., Gimenez-Conti I.B., Cunningham J.E., Collet A.M., Luna M.A., Lanfranchi H.E., Spitz M.R., and Conti C.J. Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use. Cancer 83 (1998) 204-212
-
(1998)
Cancer
, vol.83
, pp. 204-212
-
-
Xu, J.1
Gimenez-Conti, I.B.2
Cunningham, J.E.3
Collet, A.M.4
Luna, M.A.5
Lanfranchi, H.E.6
Spitz, M.R.7
Conti, C.J.8
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