In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows

American Journal of Veterinary Research

Volumn 68, Issue 3, 2007, Pages 313-322

  Pfeiffer, Julia B R ^a,c   Mevissen, Meike ^a   Steiner, Adrian ^a   Portier, Christopher J ^b   Meylan, Mireille ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ATROPINE; BETHANECHOL; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OTENZEPAD; PIRENZEPINE;

ANIMAL TISSUE; ARTICLE; CATTLE DISEASE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DAIRY CATTLE; DUODENUM; INTESTINAL DYSMOTILITY; INTESTINE MOTILITY; INTESTINE MUSCLE; JEJUNUM; NONHUMAN; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE TONE;

ANIMALS; BETHANECHOL; CATTLE; DAIRYING; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; FEMALE; JEJUNUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PARASYMPATHOMIMETICS; PIPERIDINES; PIRENZEPINE; TROPICAMIDE;

EID: 33947706804     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.68.3.313     Document Type: Article

References (63)

1. Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996;48:531-565.
2. Wrzos HF, Tandon T, Ouyang A. Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats. World J Gastroenterol 2004;10:3292-3298.
3. Uchiyama T, Chess-Williams R. Muscarinic receptor subtypes of the bladder and gastrointestinal tract. J Smooth Muscle Res 2004;40:237-247.
4. Zhang LB, Horowitz B, Buxton IL. Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes. Mol Pharmacol 1991;40:943-951.
5. Marti M, Mevissen M, Althaus H, et al. In vitro effects of bethanechol on equine gastrointestinal contractility and functional characterization of involved muscarinic receptor subtypes. J Vet Pharmacol Ther 2005;28:565-574.
6. Steiner A. Modifiers of gastrointestinal motility of cattle. Vet Clin North Am Food Anim Pract 2003;19:647-660.
7. Oyachi N, Lakshmanan J, Ahanya SN, et al. Development of ovine fetal ileal motility: role of muscarinic receptor subtypes. Am J Obstet Gynecol 2003;189:953-957.
8. Caulfield MP, Birdsall NJ. International Union of Pharmacology XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998;50:279-290.
9. Eglen RM. Muscarinic receptor subtype pharmacology and physiology. Prog Med Chem 2005;43:105-136.
10. Eglen RM. Muscarinic receptors and gastrointestinal tract smooth muscle function. Life Sci 2001;68:2573-2578.
11. Ehlert FJ, Sawyer GW, Esqueda EE. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle. Life Sci 1999;64:387-394.
12. Matsui M, Motomura D, Karasawa H, et al. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA 2000;97:9579-9584.
13. Stengel PW, Gomeza J, Wess J, et al. M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. J Pharmacol Exp Ther 2000;292:877-885.
14. Matsui M, Motomura D, Fujikawa T, et al. Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci 2002;22:10627-10632.
15. Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 1993;58:319-379.
16. Ehlert FJ, Ostrom RS, Sawyer GW. Subtypes of the muscarinic receptor in smooth muscle. Life Sci 1997;61:1729-1740.
17. Nelson DK, Pieramico O, Dahmen G, et al. M1-muscarinic mechanisms regulate interdigestive cycling of motor and secretory activity in human upper gut. Dig Dis Sci 1996;41:2006-2015.
18. Akbulut H, Goren Z, Iskender E, et al. Subtypes of muscarinic receptors in rat duodenum: a comparison with rabbit vas deferens, rat atria, guinea-pig ileum and gallbladder by using imperialine. Gen Pharmacol 1999;32:505-511.
19. Stadelmann AM, Walgenbach-Telford S, Telford GL, et al. Distribution of muscarinic receptor subtypes in rat small intestine. J Surg Res 1998;80:320-325.
20. Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol 2004;44:423-450.
21. So I, Yang DK, Kim HJ, et al. Five subtypes of muscarinic receptors are expressed in gastric smooth muscles of guinea pig. Exp Mol Med 2003;35:46-52.
22. Dorje F, Levey AI, Brann MR. Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol Pharmacol 1991;40:459-462.
23. Stoffel MH, Wicki Monnard C, Steiner A, et al. Distribution of muscarinic receptor subtypes and interstitial cells of Cajal in the gastrointestinal tract of healthy dairy cows. Am J Vet Res 2006;67:1992-1997.
24. Radostits OM, Blood DC, et al. Manifestation of alimentary tract dysfunction. In: Radostits OM, Blood DC, Hinchcliff KW, eds. Veterinary medicine. 9th ed. London: WB Saunders Co, 2000;171-176.
25. Bauer AJ, Boeckxstaens GE. Mechanisms of postoperative ileus. Neurogastroenterol Motil 2004;16:54-60.
26. Sattler D, Fecteau G, Girard C, et al. Description of 14 cases of bovine hypokalemia syndrome. Vet Rec 1998;143:503-507.
27. Roussel AJ, Brumbaugh GW, Waldron RC, et al. Abomasal and duodenal motility in yearling cattle after administration of prokinetic drugs. Am J Vet Res 1994;55:111-115.
28. Eicher R, Audige L, Braun U, et al. Epidemiology and risk factors of cecal dilatation/dislocation and abomasal displacement in dairy cows. Schweiz Arch Tierheilkd 1999;141:423-429.
29. Kilbinger H, Weihrauch TR. Drugs increasing gastrointestinal motility. Pharmacology 1982;25:61-72.
30. Megens AA, Awouters FH, Niemegeers CJ. General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride. Arzneimittelforschung 1991;41:631-634.
31. Law NM, Bharucha AE, Undale AS, et al. Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans. Am J Physiol Gastrointest Liver Physiol 2001;281: G1228-G1237.
32. Ringger NC, Lester GD, Neuwirth L, et al. Effect of bethanechol or erythromycin on gastric emptying in horses. Am J Vet Res 1996;57:1771-1775.
33. Lester GD, Merritt AM, Neuwirth L, et al. Effect of alpha 2-adrenergic, cholinergic, and nonsteroidal anti-inflammatory drugs on myoelectric activity of ileum, cecum, and right ventral colon and on cecal emptying of radiolabeled markers in clinically normal ponies. Am J Vet Res 1998;59:320-327.
34. Barahona MV, Sanchez-Fortun S, San Andres MD, et al. Acetylcholinesterase histochemistry and functional characterization of the muscarinic receptor mediating the contraction of the bovine oesophageal groove. J Auton Pharmacol 1997;17:77-86.
35. Michel A, Mevissen M, Burkhardt HW, et al. In vitro effects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows. J Vet Pharmacol Ther 2003;26:413-420.
36. Steiner A, Denac M, Ballinari U. Effects of adrenaline, dopamine, serotonin, and different cholinergic agents on smooth muscle preparations from the ansa proximalis coli in cattle: studies in vitro. Zentralbl Veterinarmed [A] 1992;39:541-547.
37. Steiner A, Roussel AJ, Martig J. Effect of bethanechol, neostigmine, metoclopramide, and propranolol on myoelectric activity of the ileocecocolic area in cows. Am J Vet Res 1995;56:1081-1086.
38. Steiner A, Meylan M, Eicher R. New aspects on the etiopathogenesis and treatment of cecal dilatation/dislocation in cows - a review Schweiz Arch Tierheilkd 1999;141:419-422.
39. Hirsbrunner G, Knutti B, Liu I, et al. An in vitro study on spontaneous myometrial contractility in the cow during estrus and diestrus. Anim Reprod Sci 2002;70:171-180.
40. Portier C, Tritscher A, Kohn M, et al. Ligand/receptor binding for 2,3,7,8-TCDD: implications for risk assessment. Fundam Appl Toxicol 1993;20:48-56.
41. Dorje F, Wess J, Lambrecht G, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 1991;256:727-733.
42. Stengel PW, Cohen ML. Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility J Pharmacol Exp Ther 2002;301:643-650.
43. Shi H, Wang H, Wang Z. Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. Mol Pharmacol 1999;55:497-507.
44. Eglen RM, Harris GC. Selective inactivation of muscarinic M2 and M3 receptors in guinea-pig ileum and atria in vitro. Br J Pharmacol 1993;109:946-952.
45. Eglen RM, Reddy H, Watson N, et al. Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol Sci 1994;15:114-119.
46. Mansfield KJ, Mitchelson FJ, Moore KH, et al. Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes. Eur J Pharmacol 2003;482:101-109.
47. Grimm U, Fuder H, Moser U, et al. Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens. Naunyn Schmiedebergs Arch Pharmacol 1994;349:1-10.
48. Hammer R, Giraldo E, Schiavi GB, et al. Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat. Life Sci 1986;38:1653-1662.
49. Giraldo E, Monferini E, Ladinsky H, et al. Muscarinic receptor heterogeneity in guinea pig intestinal smooth muscle: binding studies with AF-DX 116. Eur J Pharmacol 1987;141:475-477.
50. Eltze M, Ullrich B, Mutschler E, et al. Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney. Eur J Pharmacol 1993;238:343-355.
51. Hernandez M, Simonsen U, Prieto D, et al. Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol 1993;110:1413-1420.
52. Lazareno S, Buckley NJ, Roberts FF. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol 1990;38:805-815.
53. Stengel PW, Yamada M, Wess J, et al. M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea. Am J Physiol Regul Integr Comp Physiol 2002;282:R1443-R1449.
54. Dietrich C, Kilbinger H. Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 1995;351:237-243.
55. Sawyer GW, Ehlert FJ. Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions. J Pharmacol Exp Ther 1999;289:464-476.
56. Peralta EG, Ashkenazi A, Winslow JW, et al. Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature 1988;334:434-437.
57. Kaze C, Mevissen M, Hirsbrunner G, et al. Effect of endotoxins on contractility of smooth muscle preparations from the bovine abomasal antrum. Dtsch Tierarztl Wochenschr 2004;111:28-35.
58. Thomas EA, Baker SA, Ehlert FJ. Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum. Mol Pharmacol 1993;44:102-110.
59. Wess J. Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 1996;10:69-99.
60. Maeda A, Kubo T, Mishina M, et al. Tissue distribution of mRNAs encoding muscarinic acetylcholine receptor subtypes. FFBS Lett 1988;239:339-342.
61. Eglen RM, Cornett CM, Whiting RL. Interaction of p-F-HHSiD (p-fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol 1990;342:394-399.
62. Eglen RM, Michel AD, Montgomery WW, et al. The interaction of parafluorohexahydrosiladiphenidol at muscarinic receptors in vitro. Br J Pharmacol 1990;99:637-642.
63. Shi H, Wang H, Wang Z. M3 muscarinic receptor activation of a delayed rectifier potassium current in canine atrial myocytes. Life Sci 1999;64:PL251-PL257.