Nitric oxide accelerates the recovery from burn wounds

World Journal of Surgery

Volumn 31, Issue 4, 2007, Pages 624-631

  Zhu, Haifeng ^a   Ka, Bian ^a   Murad, Ferid ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; COLLAGEN; MYELOPEROXIDASE; NITRIC OXIDE; PROCOLLAGEN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BURN; CELL INFILTRATION; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; EPITHELIZATION; FULL THICKNESS BURN; HISTOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TOPICAL TREATMENT; WOUND CLOSURE; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; BLOTTING, WESTERN; BURNS; DISEASE MODELS, ANIMAL; GELS; IMMUNOENZYME TECHNIQUES; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM NITRITE; WOUND HEALING;

EID: 33947684769     PISSN: 03642313     EISSN: 14322323     Source Type: Journal    
DOI: 10.1007/s00268-007-0727-3     Document Type: Conference Paper

References (25)

1. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83:835-870.
2. Yamaguchi Y, Yoshikawa K. Cutaneous wound healing: an update. J Dermatol 2001;28:521-534.
3. Schwentker A, Vodovotz Y, Weller R, et al. Nitric oxide and wound repair: role of cytokines? Nitric Oxide 2002;7:1-10.
4. Childress BB, Stechmiller JK. Role of nitric oxide in wound healing. Biol Res Nurs 2002;4:5-15.
5. Lee PC, Salyapongse AN, Bragdon GA, et al. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol 1999;277:(4 Pt 2) H1600-H1608.
6. Yamasaki K, Edington HD, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998;101:967-971.
7. Shearer JD, Richards JR, Mills CD, et al. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am J Physiol 1997;272:(2 Pt 1) E181-E190.
8. Witte MB, Kiyama T, Barbul A. Nitric oxide enhances experimental wound healing in diabetes. Br J Surg 2002;89:1594-1601.
9. Shi HP, Most D, Efron DT, et al. Supplemental L-arginine enhances wound healing in diabetic rats. Wound Repair Regen 2003;11:198-203.
10. Witte MB, Thornton FJ, Tantry U, et al. L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways. Metabolism 2002;51:1269-1273.
11. Shi HP, Efron DT, Most D, et al. Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice. Surgery 2000;128:374-378.
12. Ekstrand AJ, Cao R, Bjorndahl M, et al. Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proc Natl Acad Sci USA 2003;100:6033-6038.
13. Krischel V, Bruch-Gerharz D, Suschek C, et al. Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts. J Invest Dermatol 1998;111:286-291.
14. Klein SA, Bond SJ, Gupta SC, et al. Angiogenesis inhibitor TNP-470 inhibits murine cutaneous wound healing. J Surg Res 1999;82:268-274.
15. Galeano M, Deodato B, Altavilla D, et al. Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetologia 2003;46:546-555.
16. Colwell AS, Beanes SR, Soo C, et al. Increased angiogenesis and expression of vascular endothelial growth factor during scarless repair. Plast Reconstr Surg 2005;115:204-212.
17. Detmar M, Yeo KT, Nagy JA, et al. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol 1995;105:44-50.
18. Brown LF, Yeo KT, Berse B, et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992;176:1375-1379.
19. Ziche M, Morbidelli L, Choudhuri R, et al. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 1997;99:2625-2634.
20. Morbidelli L, Chang CH, Douglas JG, et al. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 1996;270:(1 Pt 2) H411-H415.
21. Vernet D, Ferrini MG, Valente EG, et al. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide 2002;7:262-276.
22. Chu AJ, Prasad JK. Up-regulation by human recombinant transforming growth factor beta-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling. J Am Coll Surg 1999;188:271-280.
23. Witte MB, Thornton FJ, Efron DT, et al. Enhancement of fibroblast collagen synthesis by nitric oxide. Nitric Oxide 2000;4:572-582.
24. Thornton FJ, Schaffer MR, Witte MB, et al. Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds. Biochem Biophys Res Commun 1998;246:654-659.
25. Muscara MN, McKnight W, Asfaha S, et al. Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. Br J Pharmacol 2000;129:681-686.