Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1α, is another marker of lung tumor hypoxia

Acta Pharmacologica Sinica

Volumn 28, Issue 4, 2007, Pages 549-558

  Zhang, Li ^a   Li, Qing Quan ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

DEC1; HIF 1 ; Hypoxia; Lung adenocarcinoma

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CELL PROTEIN; EMBRYO CHONDROCYTE EXPRESSED GENE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

ANTISENSE THERAPY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARTILAGE CELL; CELL GROWTH; CELL HYPOXIA; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EMBRYO CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BIOLOGICAL MARKERS; CELL HYPOXIA; CELL LINE, TUMOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; PLASMIDS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 33947642521     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00516.x     Document Type: Article

References (21)

1. Brown JM. The hypoxic cell: a target for selective cancer therapyeighteenth Bruce F. Cain memorial award lecture. Cancer Res 1999; 59: 5863-70.
2. Shannon AM, Bouchier-Hayes DJ, Condron CM, Toomey D. Tumor hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 2003; 29: 297-307.
3. Harris AL. Hypoxia-a key regulatory factor in tumor growth. Nat Rev Cancer 2002; 2: 38-47.
4. Maxwell PH, Pugh CW, Ratcliffe PJ. Activation of the HIF pathway in cancer. Curr Opin Genet 2001; 11: 293-9.
5. Goonewardene TI, Sowter HM, Harris AL. Hypoxia-induced pathways in breast cancer. Microsc Res Tech 2002; 59: 41-8.
6. Pugh CW, Ratcliffe PJ. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin Cancer Biol 2003; 13: 83-9.
7. Chakrabarti J, Turley H, Campo L, Han C, Harris AL, Gatter KC, et al. The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumor grade in human breast cancers. Br J Cancer 2004; 91: 954-8.
8. Dagnon K, Pacary E, Commo F, Antoine M, Bernaudin M, Bernaudin JF, et al. Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas. Clin Cancer Res 2005; 11: 993-9.
9. Hanahan, D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
10. Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, et al. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem Biophys Res Commun 1997; 236: 294-8.
11. Rossner MJ, Dorr J, Gass P, Schwab MH, Nave KA. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol Cell Neurosci 1997; 9: 460-75.
12. Boudjelal M, Taneja R, Matsubara S, Bouillet P, Dolle P, Chambon P. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev 1997; 11: 2052-65.
13. Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, et al. Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1. Stra13. SHARP-2/ BHLHB2. J Biochem 2001; 129: 391-6.
14. Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, et al. Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem J 2002, 367: 413-22.
15. Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI. Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. J Biol Chem 2001; 276: 15306-15.
16. Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, et al. DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J Pathol 2003; 200: 222-8.
17. Turley H, Wykoff CC, Troup SS. The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumors. J Pathol 2004, 203: 808-13.
18. Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 2000; 105: 577-87.
19. Behar-Cohen FF, David T, Buechler Y, Nova MP, Houston LL, Pouliquen YM, et al. Cytotoxic effects of FGF2-saporin on bovine epithelial lens cells in vitro. Invest Ophthalmol Vis Sci 1995; 36: 2425-33.
20. Han SW, Lei ZM, Rao CV. Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into decidua. Endocrinology 1996; 137: 1791-7.
21. Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling. Oncogene 2000; 19: 6297-305.