Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised

Autonomic and Autacoid Pharmacology

Volumn 27, Issue 2, 2007, Pages 105-111

  Sanger, G J ^a   Tuladhar, B R ^b   Brown, J ^a   Aziz, E ^b   Sivakumar, D ^a   Furness, J B ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Enteric nervous system; Enteric reflexes; NK3; Synaptic transmission; Tachykinins

Indexed keywords

[2 METHOXY 5 (1 TETRAZOLYL)BENZYL](2 PHENYL 3 PIPERIDINYL)AMINE; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYL 4 QUINOLINECARBOXAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; OSANETANT; SAREDUTANT; TALNETANT; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; GUINEA PIG; ILEUM; INTESTINE; INTESTINE DISTENSION; INTESTINE INNERVATION; INTESTINE MOTILITY; INTESTINE MUCOSA; INTESTINE PRESSURE; MALE; NONHUMAN; PERISTALSIS; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STIMULUS RESPONSE; ANIMAL; CHO CELL; CRICETULUS; DRUG ANTAGONISM; HAMSTER; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; PRESSURE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; GUINEA PIGS; ILEUM; MALE; PERISTALSIS; PRESSURE; QUINOLINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3;

EID: 33947623042     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2007.00396.x     Document Type: Article

References (27)

1. ABBOTT, W.O., HARTLINE, H.K., HERVEY, J.P., INGELFINGER, F.J., RAWSON, A.J. & ZETZEL, L. (1943). Intubation studies of the human small intestine XXI. A method for measuring intra-luminal pressures and its application to the digestive tract. J. Clin. Invest., 22, 225-234.
2. ALEX, G., KUNZE, W.A.A., FURNESS, J.B. & CLERC, N. (2001). Comparison of the effects of neurokinin-3 receptor blockade on two forms of slow synaptic transmission in myenteric AH neurons. Neuroscience, 104, 263-269.
3. AMES, R., FORNWALD, J., NUTHULAGANTI, P., TRILL, J., FOLEY, J., BUCKLEY, P., KOST, T., WU, Z. & ROMANOS, M. (2004). BacMam recombinant baculoviruses in G protein-coupled receptor drug discovery. Receptors Channels, 10, 99-107.
4. BOGESKI, G., SHAFTON, A.D., KITCHENER, P.D., FERENS, D.M. & FURNESS, J.B. (2005). A quantitative approach to recording peristaltic activity from segments of rat small intestine in vivo. Neurogastroenterol. Motil., 17, 262-272.
5. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
6. DE SCHEPPER, H.U., DE WINTER, B.Y., SEERDEN, T.C., HERMAN, A.G., PELCKMANS, P.A. & DE MAN, J.G. (2005). Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum. Regul. Pept., 130, 105-115.
7. FINK, S. (1959). The intraluminal pressures in the intact human intestine. Gastroenterology, 36, 661-671.
8. 3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action. Neurogastroenterol. Motil., 15, 363-369.
9. FURNESS, J.B., KUMANO, K., LARSSON, H., MURR, E., KUNZE, W.A.A. & VOGALIS, F. (2002). Sensitization of enteric reflexes in the rat colon in vitro. Auton. Neurosci., 97, 19-25.
10. GONZALEZ, A. & SARNA, S.K. (2001). Neural regulation of in vitro giant contractions in the rat colon. Am. J. Physiol, 281, G275-G282.
11. 2 receptor mediated control of peristaltic propulsion in the guinea-pig small intestine in vitro. Neuropharmacology, 37, 131-138.
12. JOHNSON, P.J. & BORNSTEIN, J.C. (2004). Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input. Neuroscience, 126, 137-147.
13. JOHNSON, P.J., BORNSTEIN, J.C. & BURCHER, E. (1998). Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum. Br. J. Pharmacol., 124, 1375-1384.
14. JOHNSON, P.J., BORNSTEIN, J.C., YUAN, S.Y. & FURNESS, J.B. (1996). Analysis of contributions of acetylcholine and tachykinins to neuro-neuronal transmission in motility reflexes in the guinea-pig ileum. Br. J. Pharmacol., 118, 973-983.
15. JULIA, V., SU, X., BUENO, L. & GEBHART, G.F. (1999). Role of neurokinin 3 receptors on responses to colorectal distension in the rat: electrophysiological and behavioral studies. Gastroenterology, 116, 1124-1131.
16. 3 receptors in the hexamethonium-resistant inhibitory transmission in the rat colon. Naunyn Schmeidebergs Arch. Pharmacol., 353, 671-679.
17. 3 receptor mediates NANC hyperpolarisation and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon. Regul. Pept., 53, 259-274.
18. MORITA, K. & NORTH, R.A. (1985). Significance of slow synaptic potentials for transmission of excitation in guinea-pig myenteric plexus. Neuroscience, 14, 661-672.
19. NEUNLIST, M., DOBREVA, G. & SCHEMANN, M. (1999). Characteristics of mucosally projecting myenteric neurones in the guinea-pig proximal colon. J. Physiol., 517, 533-546.
20. ONORI, L., AGGIO, A., TADDEI, G., CICCOCIOPPO, R., SEVERI, C., CARNICELLI, V. & TONINI, M. (2001). Contribution of NK3 tachykinin receptors to propulsion in the rabbit isolated distal colon. Neurogastroenterol. Motil., 13, 211-219.
21. PATTON, D., O'REILLY, M. & VANNER, S. (2005). Sensory peptide neurotransmitters mediating mucosal and distension evoked neural vasodilator reflexes in guinea-pig ileum. Am. J. Physiol., 289, G785-G790.
22. 2 receptors as targets for drugs to treat gastrointestinal motility disorders and pain. Br. J. Pharmacol., 141, 1303-1312.
23. 3 receptors in enteric reflexes evoked by relatively intense stimuli. Gastroenterology, 122 (Suppl. 1), A256.
24. SARAU, H.M., GRISWOLD, D.E., POTTS, W. et al. (1997). Nonpeptide tachykinin receptor antagonists. I. Pharmacological and pharmokinetic characterisation of SB-223412, a novel, potent and selective neurokinin-3 receptor antagonist. J. Pharmacol. Exp. Ther., 281, 1303-1311.
25. 3 receptor antagonist, SB-235375, on intestinal and somatic nociceptive responses and on intestinal motility in anaesthetised rats. Neurogastroenterol. Motil., 16, 223-231.
26. i using the fluorometric imaging plate reader (FLIPR). In: Calcium Signalling Protocols (Ed.D.G. LAMBERT ), pp. 125-136, Humana Press, New Jersey.
27. 3 Receptor antagonist talnetant (SB-223412) modulates peristalsis induced by supra-optimal distension pressure in the guinea-pig isolated ileum. Gastroenterol, 126 (Suppl. 2), A277.